Margaret A Wallace

US Patent:

58591958, Jan 12, 1999

Filed:

May 25, 1995

Appl. No.:

8/449933

Inventors:

Francis S. Collins - Ann Arbor MI
Margaret R. Wallace - Ann Arbor MI
Douglas A. Marchuk - Ann Arbor MI
Lone B. Andersen - Ann Arbor MI
David H. Gutmann - Ann Arbor MI

Assignee:

The Regents of the University of Michigan - Ann Arbor MI

International Classification:

C07K 14435
C07H 2104

US Classification:

530350

Abstract:

The entire coding region of the gene involved in von Recklinghausen neurofibromatosis (NF1) and a ubiquitously expressed large transcript (NF1LT) of the gene have been identified, cloned and sequenced. With the identification of the NF1 gene and its gene product, nucleic acid probes and antibodies raised to the gene product can be used in a variety of hybridization and immunological assays to screen for NF1 and detect it in its early stages. Conventional and gene therapies can also be developed to treat those afflicted with the disease.

US Patent:

62388614, May 29, 2001

Filed:

Aug 2, 1993

Appl. No.:

7/966049

Inventors:

Francis S. Collins - Ann Arbor MI
Margaret R. Wallace - Ann Arbor MI
Douglas A. Marchuk - Ann Arbor MI
Lone B. Andersen - Ann Arbor MI
David H. Gutmann - Ann Arbor MI

Assignee:

The Regents of the University of Michigan - Ann Arbor MI

International Classification:

C12Q 168
C12P 1934
C07H 2104
C07K 14435

US Classification:

435 6

Abstract:

The invention relates to the gene involved in the von Recklinghausen neurofibromatosis (NF1) disease process and to the identification, isolation and cloning of a nucleic acid sequence corresponding to the gene. The invention further relates to the NF1 gene product and sequence and antibodies raised thereto. The invention also relates to methods of screening for NF1 and NF1 diagnosis, as well as conventional treatment and gene therapy utilizing recombinant technologies.