Marie Chow

US Patent:

6764837, Jul 20, 2004

Filed:

Jan 16, 2002

Appl. No.:

09/958940

Inventors:

Shouguang Jin - Gainesville FL
Scott M. Lohrke - Beltsville MD
Konstantin Severinov - Highland Park NJ
Marie Chow - Little Rock AR

Assignee:

Board of Trustees of the University of Arkansas - Little Rock AR
Rutgers the State University of New Jersey - Piscataway NJ

International Classification:

C12N 1509

US Classification:

435 697, 435 691, 435325, 4352523, 4353201, 435471, 536 231, 536 234, 536 241

Abstract:

The present invention is directed to a method for expression of at least one heterologous gene in a host cell comprising transforming a host cell with at least one nucleic acid construct comprising a complete subunit of an RNA polymerase or a portion thereof of a hybrid nucleic acid containing a portion of the subunit of an RNA polymerase obtained from the same genus as the heterologous gene, and transforming the host cell, with at least one heterologous gene; and culturing the transformed host cell. The present invention further is directed to nucleic acid molecules used in the present method, vectors containing these nucleic acid molecules, and host cells containing the nucleic acid molecules. The nucleic acid encoding the subunit of an Agrobacterium RNA polymerase and the corresponding amino acid sequence and portions thereof is disclosed.

US Patent:

7326528, Feb 5, 2008

Filed:

Dec 22, 2003

Appl. No.:

10/746672

Inventors:

Marie Chow - Little Rock AR, US
Courtney Wilkins - Little Rock AR, US
Khaled Machaca - Little Rock AR, US

Assignee:

Board of Trustees of the University of Arkansas - Little Rock AR

International Classification:

C12Q 1/70
A61K 39/12

US Classification:

435 5, 4242041

Abstract:

The present invention provides methods for studying pathogenesis of mammalian viruses. In particular, the present invention provides a nonhuman animal model system for studying disease mechanism wherein the nonhuman animal model is infected with an animal virus. In a preferred embodiment, the animal model is and the animal virus is vesicular stomatitis virus (VSV).

US Patent:

7932430, Apr 26, 2011

Filed:

Nov 1, 2007

Appl. No.:

11/982162

Inventors:

Marie Chow - Little Rock AR, US
Courtney Wilkins - Little Rock AR, US
Khaled Machaca - Little Rock AR, US

Assignee:

Board of Trustees of the University of Arkansas - Little Rock AR

International Classification:

A61K 39/12

US Classification:

800 13, 800 21, 4242041

Abstract:

The present invention provides methods for studying pathogenesis of mammalian viruses. In particular, the present invention provides a nonhuman animal model system for studying disease mechanisms wherein the nonhuman animal model is infected with an animal virus. In a preferred embodiment the animal model is and the animal virus is vesicular stomatitis virus (VSV).

US Patent:

53087011, May 3, 1994

Filed:

May 8, 1992

Appl. No.:

7/880248

Inventors:

Smadar Cohen - Petach-Tickya, IL
Carmen Bano - 46020 Valencia, ES
Karyn B. Visscher - State College PA
Marie B. Chow - Brookline MA
Harry R. Allcock - State College PA
Robert S. Langer - Newton MA

International Classification:

B01J 1302

US Classification:

42840222

Abstract:

A method for encapsulating biologically-labile materials such as proteins, liposomes, bacteria and eucaryotic cells within a synthetic polymeric capsule, and the product thereof, are disclosed. The method is based on the use of a water-soluble polymer with charged side chains that are crosslinked with multivalent ions of the opposite charge to form a gel encapsulating biological material, that is optionally further stabilized by interactions with multivalent polyions of the same charge as those used to form the gel. In the preferred embodiment, hydrolytically stable polyphosphazenes are formed of monomers having carboxylic acid side groups that are crosslinked by divalent or trivalent cations such as Ca. sup. 2+ or Al. sup. 3+, then stabilized with a polycation such as poly-L-lysine. A variety of different compositions can be formed from the crosslinked polymer.

US Patent:

51495430, Sep 22, 1992

Filed:

Oct 5, 1990

Appl. No.:

7/593684

Inventors:

Smadar Cohen - Petach-Tickva, IL
Carmen Bano - Valencia, ES
Karyn B. Visscher - State College PA
Marie Chow - Brookline MA
Harry R. Allcock - State College PA
Robert S. Langer - Newton MA

Assignee:

Massachusetts Institute of Technology - Cambridge MA
Pennsylvania Research Corporation - University Park PA

International Classification:

A61K 950

US Classification:

424499

Abstract:

A method for encapsulating biologically-labile materials such as proteins, liposomes, bacteria and eucaryotic cells within a synthetic polymeric capsule, and the product thereof, are disclosed. The method is based on the use of a water-soluble polymer with charged side chains that are crosslinked with multivalent ions of the opposite charge to form a gel encapsulating biological material, that is optionally further stabilized by interactions with multivalent polyions of the same charge as those used to form the gel. In the preferred embodiment, hydrolytically stable polyphosphazenes are formed of monomers having carboxylic acid side groups that are crosslinked by divalent or trivalent cations such as Ca. sup. 2+ or Al. sup. 3+, then stabilized with a polycation such as poly-L-lysine. A variety of different compositions can be formed from the crosslinked polymer.

US Patent:

52308880, Jul 27, 1993

Filed:

May 29, 1990

Appl. No.:

7/530468

Inventors:

David Baltimore - Cambridge MA
Marie B. Chow - Cambridge MA

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61K 3900

US Classification:

424 86

Abstract:

The production of neutralizing antibodies for poliovirus, or other enteroviruses, are disclosed herein employing the capsid polypeptide VP1. Vaccines can be produced employing this polypeptide in place of killed or live attenuated virus, and the VP1 polypeptide can be employed in assays in place of whole virions. VP1 polypeptide can be produced by isolating it from live virion or can be produced by cloning cDNA sequences coding for this protein in recombinant cDNA vectors.

US Patent:

56185391, Apr 8, 1997

Filed:

Sep 29, 1994

Appl. No.:

8/314571

Inventors:

Brent Dorval - Leominster MA
Marie Chow - Brookline MA
Alexander Klibanov - Newton MA

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61K 3913

US Classification:

4242171

Abstract:

Non-lyophilized vaccine compositions which contain a poliovirus and, as stabilizer, a compound containing at least two amino or imine groups. The stabilizers include polyimines such as the amino acid lysine or ethylenediamine and polyimines such as poly(ethylenimine).

US Patent:

54946824, Feb 27, 1996

Filed:

Mar 18, 1994

Appl. No.:

8/210018

Inventors:

Smadar Cohen - Petach-Tickya, IL
Carmen Bano - Valencia, ES
Karyn B. Visscher - State College PA
Marie Chow - Brookline MA
Harry R. Allcock - State College PA
Robert S. Langer - Newton MA

Assignee:

Massachusetts Institute of Technology - Cambridge MA
The Penn State Research Foundation - University Park PA

International Classification:

B01J 1302
A61K 950

US Classification:

424489

Abstract:

A method for encapsulating biologically-labile materials such as proteins, liposomes, bacteria and eucaryotic cells within a synthetic polymeric capsule, and the product thereof, are disclosed. The method is based on the use of a water-soluble polymer with charged side chains that are crosslinked with multivalent ions of the opposite charge to form a gel encapsulating biological material, that is optionally further stabilized by interactions with multivalent polyions of the same charge as those used to form the gel. In the preferred embodiment, hydrolytically stable polyphosphazenes are formed of monomers having carboxylic acid side groups that are crosslinked by divalent or trivalent cations such as Ca. sup. 2+ or Al. sup. 3+, then stabilized with a polycation such as poly-L-lysine. A variety of different compositions can be formed from the crosslinked polymer.