Marie A Reynolds

US Patent:

20080306282, Dec 11, 2008

Filed:

Jul 11, 2005

Appl. No.:

11/572333

Inventors:

Joseph F. Krzyzaniak - Pawcatuck CT, US
George M. Laurence - Lawrence KS, US
Aeri Park - West Lafayette IN, US
Kevin J. Quackenbush - Noank CT, US
Marie L. Reynolds - Lebanon CT, US
Peter R. Rose - Ledyard CT, US
Timothy A. Woods - Remington IN, US

International Classification:

C07D 207/34

US Classification:

548537

Abstract:

Novel forms of [R—(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemi calcium salt designated Form XX, Form XXI, Form XXII, Form XXIII, Form XXIV, Form XXV, Form XXVI, Form XXVII, Form XXVIII, Form XXIX, and Form XXX, characterized by their X-ray powder diffraction, solid-state NMR, and/or Raman spectroscopy are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, benign prostatic hyperplasia (BPH) and Alzheimer's disease.

US Patent:

20110301358, Dec 8, 2011

Filed:

Aug 22, 2011

Appl. No.:

13/214559

Inventors:

Joseph F. Krzyzaniak - Pawcatuck CT, US
George M. Laurence - Lawrence KS, US
Aeri Park - West Lafayette IN, US
Kevin J. Quackenbush - Groton CT, US
Marie L. Reynolds - Lebanon CT, US
Peter R. Rose - Ledyard CT, US
Timothy A. Woods - Remington IN, US

Assignee:

Pfizer Inc. - New York NY

International Classification:

C07D 207/34

US Classification:

548537

Abstract:

Novel forms of [R—(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemi calcium salt designated Form XX, Form XXI, Form XXII, Form XXIII, Form XXIV, Form XXVV, Form XXVI, Form XXVII, Form XXVIII, Form XXIX, and Form XXX, characterized by their X-ray powder diffraction, solid-state NMR, and/or Raman spectroscopy are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, benign prostatic hyperplasia (BPII) and Alzheimer's disease.