Marion Sim Reid

US Patent:

7449295, Nov 11, 2008

Filed:

Oct 24, 2005

Appl. No.:

11/257285

Inventors:

Ghazala Hashmi - Holmdel NJ, US
Michael Seul - Fanwood NJ, US
Marion E. Reid - Jamaica Estates NY, US
Michael Pierce - Flemington NJ, US

Assignee:

Bio Array Solutions - Warren NJ
New York Blood Center - New York NY

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

Disclosed are a method and an algorithm for genetic cross-matching based on the comparison of recipient and donor genotypes—and the underlying combinations of alleles and haplotypes. The method of the invention, rather than focusing on phenotype prediction, instead relies on a comparison of genetic variants identified in the recipient and available donors, whose information preferably will be compiled in a widely available donor registry, to maximize molecular compatibility. The genotypes can be matched based on the weighted clinical significance of a genotypic difference between donor and recipient, such that certain mismatches are more acceptable than others.

US Patent:

7612193, Nov 3, 2009

Filed:

Sep 9, 2008

Appl. No.:

12/206859

Inventors:

Ghazala Hashmi - Holmdel NJ, US
Michael Seul - Fanwood NJ, US
Marion E. Reid - Jamaica Estates NY, US
Michael Pierce - Flemington NJ, US

Assignee:

BioArray Solutions Ltd. - Warren NJ

International Classification:

C07H 21/04
C12N 15/12

US Classification:

536 2433

Abstract:

Disclosed are a method and an algorithm for genetic cross-matching based on the comparison of recipient and donor genotypes—and the underlying combinations of alleles and haplotypes. The method of the invention, rather than focusing on phenotype prediction, instead relies on a comparison of genetic variants identified in the recipient and available donors, whose information preferably will be compiled in a widely available donor registry, to maximize molecular compatibility. The genotypes can be matched based on the weighted clinical significance of a genotypic difference between donor and recipient, such that certain mismatches are more acceptable than others.

US Patent:

20090104612, Apr 23, 2009

Filed:

Oct 20, 2008

Appl. No.:

12/254707

Inventors:

Marion Reid - Jamaica NY, US
Asok Chaudhuri - Hicksville NY, US

Assignee:

New York Blood Center, Inc. - New York NY

International Classification:

C12Q 1/68
C07H 21/04

US Classification:

435 6, 536 231

Abstract:

Disclosed herein are nucleic acid molecules which permit the accurate and direct determination of blood groups based on the presence of certain genes. A method of determining blood groups is also provided.

US Patent:

60546328, Apr 25, 2000

Filed:

Nov 15, 1996

Appl. No.:

8/749527

Inventors:

Marion E. Reid - New York NY

Assignee:

New York Blood Center, Inc. - New York NY

International Classification:

A61K 4800
C12N 510
C12N 528
C12N 1509

US Classification:

800 6

Abstract:

The invention relates to a method for making monoclonal antibodies having pre-defined specificity for an epitope characteristic of or unique to a single form of a polymorphic protein. The method includes constructing a first transgenic animal to express a first form of a polymorphic protein encoded by a first allele of a gene encoding the protein; constructing a second transgenic animal to express a second form of the polymorphic protein encoded by a second allele of the gene encoding the protein; and immunizing the first transgenic animal with cells from the second transgenic animal expressing the second form of the polymorphic protein to induce an immune response in the first transgenic animal yielding an antibody specific for an epitope peculiar to the second form of the polymorphic protein. The invention further includes hybridoma cells secreting a monoclonal antibody specific for the second form of the protein. The invention is particularly advantageous in the context of making monoclonal antibodies and derivative reagents specifically identifying polymorphic blood group proteins, such as the Duffy gp-Fy protein.