Mark R Alderson

US Patent:

6355779, Mar 12, 2002

Filed:

Sep 10, 1998

Appl. No.:

09/150864

Inventors:

Raymond G. Goodwin - Seattle WA
Craig A. Smith - Seattle WA
Mark R. Alderson - Bainbridge Island WA

Assignee:

Immunex Corporation - Seattle WA

International Classification:

C07K 1600

US Classification:

53038823, 53038822, 530350, 530351, 435 691, 436501, 536 235, 536 2431

Abstract:

Novel 4-1BB ligand (4-1BB-L) polypeptides and a human cell surface receptor designated 4-1BB that binds 4-1BB-L are provided. Isolated 4-1BB-L-encoding and human 4-1BB-encoding DNA sequences, recombinant expression vectors comprising the isolated DNA sequences, and host cells transformed with the recombinant expression vectors are disclosed, along with methods for producing the novel polypeptides by cultivating such transformed host cells. Soluble forms of the 4-1BB-L or 4-1BB polypeptides are derived from the extracellular domains thereof.

US Patent:

6544522, Apr 8, 2003

Filed:

Dec 30, 1998

Appl. No.:

09/223040

Inventors:

Yasir Skeiky - Seattle WA
Mark Alderson - Bainbridge Island WA
Antonio Campos-Neto - Bainbridge Island WA

Assignee:

Corixa Corporation - Seattle WA

International Classification:

A61K 3902

US Classification:

4241901, 424 92, 4241301, 4241641, 4241681, 4242481, 435 691, 435 693, 514 44, 530350, 536 231, 536 237

Abstract:

The present invention relates to fusion proteins of antigens. In particular, it relates to two fusion proteins, each of which contains three individual antigens, and a fusion protein of two antigens, their coding sequences, and methods for their use in the treatment and prevention of tuberculosis.

US Patent:

6555653, Apr 29, 2003

Filed:

May 5, 1998

Appl. No.:

09/073009

Inventors:

Mark Raymond Alderson - Bainbridge Island WA
Davin C. Dillon - Redmond WA
Yasir A. W. Skeiky - Seattle WA
Antonio Campos-Neto - Bainbridge Island WA

Assignee:

Corixa Corporation - Seattle WA

International Classification:

C07K 100

US Classification:

530350, 4242481, 4241841, 4242341, 4241921, 4241681, 536 231

Abstract:

Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more proteins, and DNA sequences encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.

US Patent:

6613881, Sep 2, 2003

Filed:

May 5, 1998

Appl. No.:

09/073010

Inventors:

Mark Raymond Alderson - Bainbridge Island WA
Davin C. Dillon - Redmond WA
Yasir A. W. Skeiky - Seattle WA
Antonio Campos-Neto - Bainbridge Island WA

Assignee:

Corixa Corporation - Seattle WA

International Classification:

C07K 100

US Classification:

530350, 536 231, 435 6

Abstract:

Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against infection, or may be used for the diagnosis of tuberculosis.

US Patent:

6627198, Sep 30, 2003

Filed:

Apr 7, 1999

Appl. No.:

09/287849

Inventors:

Steven G. Reed - Bellevue WA
Yasir A. Skeiky - Seattle WA
Davin C. Dillon - Redmond WA
Mark Alderson - Bainbridge Island WA
Antonio Campos-Neto - Bainbridge Island WA

Assignee:

Corixa Corporation - Seattle WA

International Classification:

A61K 3902

US Classification:

4241901, 424 92, 4241301, 4241641, 4241681, 4242481, 435 691, 435 693, 514 44, 530350, 536 231, 536 237

Abstract:

The present invention relates to fusion proteins containing at least two antigens. In particular, it relates to bi-fusion proteins which contain two individual antigens, tri-fusion proteins which contain three antigens, tetra-fusion proteins which contain four antigens, and penta-fusion proteins which contain five antigens, and methods for their use in the diagnosis, treatment and prevention of tuberculosis infection.

US Patent:

7064195, Jun 20, 2006

Filed:

Feb 5, 2003

Appl. No.:

10/359459

Inventors:

Yasir Skeiky - Bellevue WA, US
Mark Alderson - Bainbridge Island WA, US
Antonio Campos-Neto - Bainbridge Island WA, US

Assignee:

Corixa - Seattle WA

International Classification:

C07H 21/04
C07H 21/02
A61K 39/04

US Classification:

536 237, 424 92, 4241301, 4241641, 4241681, 4241901, 4242481, 435 691, 435 693, 514 44, 530350, 536 231

Abstract:

The present invention relates to fusion proteins of antigens. In particular, it relates to two fusion proteins, each of which contains three individual antigens, and a fusion protein of two antigens, their coding sequences, and methods for their use in the treatment and prevention of tuberculosis.

US Patent:

7083796, Aug 1, 2006

Filed:

Jun 20, 2001

Appl. No.:

09/886349

Inventors:

Yasir Skeiky - Seattle WA, US
Steven Reed - Bellevue WA, US
Mark Alderson - Bainbridge Island WA, US

Assignee:

Corixa Corporation - Seattle WA

International Classification:

A61K 39/04
A61K 49/00
A61K 45/00

US Classification:

4242481, 424 91, 424 92, 4241841, 4241851, 4241901, 4241921, 4242341, 4242781, 530300, 530350

Abstract:

The present invention relates to compositions and fusion proteins containing at least two sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.

US Patent:

7138500, Nov 21, 2006

Filed:

Sep 10, 1998

Appl. No.:

09/151259

Inventors:

Raymond G. Goodwin - Seattle WA, US
Craig A. Smith - Seattle WA, US
Mark R. Alderson - Bainbridge Island WA, US

Assignee:

Immunex Corporation - Thousand Oaks CA

International Classification:

A61K 39/395
C12P 21/08
G01N 33/567
C07H 21/04
C07K 14/52

US Classification:

53038822, 530350, 530351, 435 721, 435 691, 435 695, 435326, 435335, 4241301, 4241431, 436501, 536 231

Abstract:

Novel 4-1BB ligand (4-1BB-L) polypeptides and a human cell surface receptor designated 4-1BB that binds 4-1BB-L are provided. Isolated 4-1BB-L-encoding and human 4-1BB-encoding DNA sequences, recombinant expression vectors comprising the isolated DNA sequences, and host cells transformed with the recombinant expression vectors are disclosed, along with methods for producing the novel polypeptides by cultivating such transformed host cells. Soluble forms of the 4-1BB-L or 4-1BB polypeptides are derived from the extracellular domains thereof.