Mark A Creswell

US Patent:

6506701, Jan 14, 2003

Filed:

Mar 13, 2001

Appl. No.:

09/804860

Inventors:

Gary L. Bolton - Ann Arbor MI
Richard J. Booth - Ypsilanti MI
Mark W. Creswell - Chelsea MI
John C. Hodges - Ann Arbor MI
Joseph S. Warmus - Ann Arbor MI
Michael W. Wilson - Ann Arbor MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

B01J 2034

US Classification:

502 20, 502 21, 502 22, 502 29, 502 34, 502401, 502402

Abstract:

Novel polymer-supported quenching reagents of Formula I, wherein P is a polymer of low chemical reactivity which is soluble or insoluble; Q is one or more quenching reagents, or an acid or base addition salts thereof, that are capable of selective covalent reaction with unwanted byproducts, or excess reagents; and L is one or more chemically robust linkers that join P and Q; are described, as well as methods for their preparation and methods for their use in the rapid purification of synthetic intermediates and products in organic synthesis, combinatorial chemistry and automated organic synthesis.

US Patent:

63069598, Oct 23, 2001

Filed:

Oct 15, 1998

Appl. No.:

9/171258

Inventors:

Gary L. Bolton - Ann Arbor MI
Richard J. Booth - Ypsilanti MI
Mark W. Creswell - Chelsea MI
John C. Hodges - Ann Arbor MI
Joseph S. Warmus - Ann Arbor MI
Michael W. Wilson - Ann Arbor MI

Assignee:

Warner Lambert Company - Ann Arbor MI

International Classification:

C08G 6348

US Classification:

525 541

Abstract:

Novel polymer-supported quenching reagents of Formula (I): P-L-Q, wherein P is a polymer of low chemical reactivity which is soluble or insoluble; Q is one or more quenching reagents, or an acid or base addition salts thereof, that are capable of selective covalent reaction with unwanted byproducts, or excess reagents; and L is one or more chemically robust linkers that join P and Q; are described, as well as methods for their preparation and methods for their use in the rapid purification of synthetic intermediates and products in organic synthesis, combinatorial chemistry and automated organic synthesis.

US Patent:

49978373, Mar 5, 1991

Filed:

Oct 6, 1989

Appl. No.:

7/417996

Inventors:

Alexander W. Chucholowski - Ypsilanti MI
Mark W. Creswell - Chelsea MI
Bruce D. Roth - Ann Arbor MI
Drago R. Sliskovic - Ypsilanti MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

C07D40506
A61K 31365

US Classification:

514256

Abstract:

Certain trans-6-[[(substituted)pyridin-3-yl]-alkyl- and alkenyl]tetrahydro-4-hydroxypyran-2-ones and the corresponding ring-opened acids derived therefrom are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) and are useful as hypocholesterolemic and hypolipidemic agents.

US Patent:

58308687, Nov 3, 1998

Filed:

Jun 27, 1996

Appl. No.:

8/671460

Inventors:

Gary Louis Bolton - Ann Arbor MI
Mark Wallace Creswell - Chelsea MI
John Cooke Hodges - Ann Arbor MI
Michael William Wilson - Ann Arbor MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61K 3805
A61K 3806

US Classification:

514 18

Abstract:

Novel inhibitors of protein:farnesyl transferase enzyme are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in controlling tissue proliferative diseases, including cancer and restenosis.

US Patent:

49066242, Mar 6, 1990

Filed:

Aug 2, 1988

Appl. No.:

7/226190

Inventors:

Alexander W. Chucholowski - Ypsilanti MI
Mark W. Creswell - Chelsea MI
Bruce D. Roth - Ann Arbor MI
Drago R. Sliskovic - Ypsilanti MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

C07D40506
A61K 31365

US Classification:

514210

Abstract:

Certain trans-6-[[(substituted)pyridin-3-yl]-alkyl- and alkenyl]tetrahydro-4-hydroxypyran-2-ones and the corresponding ring-opened acids derived therefrom are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) and are useful as hypocholesterolemic and hypolipidemic agents.