Mark W Creswell

US Patent:

6472418, Oct 29, 2002

Filed:

Jun 18, 2001

Appl. No.:

09/868449

Inventors:

Mark Wallace Creswell - Chelsea MI
Michael Higginbottom - Cambridgeshire, GB
David Christopher Horwell - Cambridge, GB
Russel Andrew Lewthwaite - Cambridge, GB
Martyn Clive Pritchard - Cambrigeshire, GB
Jennifer Raphy - Herts, GB

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61K 31404

US Classification:

514422, 548467, 548490, 548494

Abstract:

Non-peptide acetamide derivatives of Formula I are specific NK antagonist, where R is aryl, R and R are H or alkyl, m, n and q are integers from 0 to 4, X is NR or NHCONH, R and R are H or alkyl, R is naphthyl or indolyl, R and R are H or alkyl, and R is aryl. The compounds are useful agents for treating inflammatory and allergic disorders, pain, anxiety, depression, schizophrenia and emesis.

US Patent:

6506701, Jan 14, 2003

Filed:

Mar 13, 2001

Appl. No.:

09/804860

Inventors:

Gary L. Bolton - Ann Arbor MI
Richard J. Booth - Ypsilanti MI
Mark W. Creswell - Chelsea MI
John C. Hodges - Ann Arbor MI
Joseph S. Warmus - Ann Arbor MI
Michael W. Wilson - Ann Arbor MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

B01J 2034

US Classification:

502 20, 502 21, 502 22, 502 29, 502 34, 502401, 502402

Abstract:

Novel polymer-supported quenching reagents of Formula I, wherein P is a polymer of low chemical reactivity which is soluble or insoluble; Q is one or more quenching reagents, or an acid or base addition salts thereof, that are capable of selective covalent reaction with unwanted byproducts, or excess reagents; and L is one or more chemically robust linkers that join P and Q; are described, as well as methods for their preparation and methods for their use in the rapid purification of synthetic intermediates and products in organic synthesis, combinatorial chemistry and automated organic synthesis.

US Patent:

20030065007, Apr 3, 2003

Filed:

Oct 9, 2002

Appl. No.:

10/267477

Inventors:

Mark Creswell - Chelsea MI, US
Michael Higginbottom - Cambridgeshire, GB
David Horwell - Cambridge, GB
Russel Lewthwaite - Cambridge, GB
Martyn Pritchard - Cambridgeshire, GB
Jennifer Raphy - Herts, GB

International Classification:

C07D333/52
C07D333/22
C07D217/06
C07D217/12

US Classification:

514/307000, 514/357000, 514/375000, 514/311000, 514/406000, 514/394000, 514/438000, 514/415000, 514/443000, 514/469000, 514/471000, 514/563000, 514/617000, 546/146000, 546/175000, 546/336000, 548/217000, 548/309700, 548/375100, 548/494000, 548/567000, 549/049000, 549/076000, 549/467000, 562/455000, 564/161000, 514/408000

Abstract:

Non-peptide acetamide derivatives of Formula I are specific NKantagonists, where R is aryl, Rand Rare H or alkyl, m, n and q are integers from 0 to 4, X is NRor NHCONH, Rand Rare H or alkyl, Ris naphthyl or indolyl, Rand Rare H or alkyl, and Ris aryl. The compounds are useful agents for treating inflammatory and allergic disorders, pain, anxiety, depression, schizophrenia and emesis.

US Patent:

51532263, Oct 6, 1992

Filed:

Jul 30, 1990

Appl. No.:

7/557204

Inventors:

Alexander W. Chucholowski - Bad Krozingen, DE
Mark W. Creswell - Chelsea MI
William H. Roark - Ann Arbor MI
Ila Sircar - Ann Arbor MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61K 3118
A61K 31165

US Classification:

514617

Abstract:

The present invention are novel amino acid amide compounds of the following general formula which inhibit the enzyme acylcoenzyme A:cholesterol acyltransferase: ##STR1## wherein R is phenyl or 1- or 2-naphthyl which are unsubstituted or may be substituted; R. sub. 1 is hydrogen or a straight or branched alkyl group having from 1 to 6 carbon atoms; R. sub. 2 is hydrogen, an aliphatic group, an aromatic group, an aralkyl or diarylalkyl group or R. sub. 1 and R. sub. 2 form a carbocyclic group; R. sub. 3 is hydrogen, an aliphatic group, an aralkyl group wherein the alkyl moiety may contain a carbocyclic entity; R. sub. 4 is hydrogen, an aliphatic group, SO. sub. 2 R. sub. 14, --C(. dbd. S)NHR. sub. 15, --CO. sub. 2 R. sub. 15, --COR. sub. 18, or --C(. dbd. O)NHR. sub. 15 wherein R. sub.

US Patent:

51623609, Nov 10, 1992

Filed:

Jun 24, 1991

Appl. No.:

7/719878

Inventors:

Mark W. Creswell - Chelsea MI
Andrew D. White - Lakeland MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61K 31495
C07D27704
C07D40100
C07D41300

US Classification:

514371

Abstract:

The present invention provides N-substituted aryl-N'-heterocyclic substituted ureas and thioureas of the formula ##STR1## wherein R. sub. 1, R. sub. 2 and R. sub. 3 are hydrogen, fluorine, chlorine, bromine, alkyl, alkoxy, substituted or unsubstituted benzoyl, substituted or unsubstituted phenyl, amino, substituted amino, or a monocyclic heterocyclic, or a carboxy group; and Het is a substituted monocyclic heterocyclic group containing two hetero atoms selected from nitrogen, oxygen or sulfur; which are useful in treating hypercholesterolemia and atherosclerosis.

US Patent:

63069598, Oct 23, 2001

Filed:

Oct 15, 1998

Appl. No.:

9/171258

Inventors:

Gary L. Bolton - Ann Arbor MI
Richard J. Booth - Ypsilanti MI
Mark W. Creswell - Chelsea MI
John C. Hodges - Ann Arbor MI
Joseph S. Warmus - Ann Arbor MI
Michael W. Wilson - Ann Arbor MI

Assignee:

Warner Lambert Company - Ann Arbor MI

International Classification:

C08G 6348

US Classification:

525 541

Abstract:

Novel polymer-supported quenching reagents of Formula (I): P-L-Q, wherein P is a polymer of low chemical reactivity which is soluble or insoluble; Q is one or more quenching reagents, or an acid or base addition salts thereof, that are capable of selective covalent reaction with unwanted byproducts, or excess reagents; and L is one or more chemically robust linkers that join P and Q; are described, as well as methods for their preparation and methods for their use in the rapid purification of synthetic intermediates and products in organic synthesis, combinatorial chemistry and automated organic synthesis.

US Patent:

51853582, Feb 9, 1993

Filed:

Jun 24, 1991

Appl. No.:

7/719907

Inventors:

Mark W. Creswell - Chelsea MI
Andrew D. White - Lakeland MI

Assignee:

Warner-Lambert Co. - Morris Plains NJ

International Classification:

A61K 3141
C07D24912
C07D24908
C07D40314

US Classification:

514383

Abstract:

Compounds useful in treating hypercholesterolemia and atherosclerosis having the formula ##STR1## wherein X is oxygen or sulfur, Het is a monocyclic heterocyclic group having three hetero atoms selected from nitrogen, oxygen and sulfur, and R. sub. 1, R. sub. 2 and R. sub. 3 are hydrogen, flourine, chlorine, bromine, a straight or branched alkyl group having from 1 to 6 carbon atoms, a straight or branched alkoxy group having from 1 to 6 carbon atoms, substituted or unsubstituted benzoyl, substituted or unsubstituted benzoyl, substituted or unsubstituted phenyl, amino or substituted amino or a carboxy group.

US Patent:

49978373, Mar 5, 1991

Filed:

Oct 6, 1989

Appl. No.:

7/417996

Inventors:

Alexander W. Chucholowski - Ypsilanti MI
Mark W. Creswell - Chelsea MI
Bruce D. Roth - Ann Arbor MI
Drago R. Sliskovic - Ypsilanti MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

C07D40506
A61K 31365

US Classification:

514256

Abstract:

Certain trans-6-[[(substituted)pyridin-3-yl]-alkyl- and alkenyl]tetrahydro-4-hydroxypyran-2-ones and the corresponding ring-opened acids derived therefrom are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) and are useful as hypocholesterolemic and hypolipidemic agents.