Mark Evans Fleming

US Patent:

6665060, Dec 16, 2003

Filed:

Oct 29, 1999

Appl. No.:

09/430117

Inventors:

David J. Zahniser - Wellesley MA
Matthew S. Zelinski - Worthington OH
Thomas Dolash - Worthington OH
Garrick L. Maenle - Columbus OH
Mark Fleming - Columbus OH
John Laudo - Columbus OH

Assignee:

Cytyc Corporation - Boxborough MA

International Classification:

G01N 3348

US Classification:

356 39, 422 8201, 436164

Abstract:

The present invention relates to the analysis of cytological material. Specifically, the invention relates to stains and methods of producing the stains, methods of staining cells for cytological or histological analysis to contrast the nuclear portion of the cell from the cytoplasmic portion, and systems and methods for illuminating a cytological sample. The analysis can be automated or manual.

US Patent:

6876955, Apr 5, 2005

Filed:

Dec 20, 2002

Appl. No.:

10/324075

Inventors:

Mark Fleming - Vienna VA, US
Chionglong Kuo - Arlington VA, US

Assignee:

Fannie Mae - Washington DC

International Classification:

G06F017/60

US Classification:

702194, 702181, 702182, 705 35

Abstract:

A system and method of accurately predicting and reporting a value of a property based on a weighted average of values predicted by at least two prediction models. The system and method include the steps of accessing predicted values, determined by the prediction models, for the property; determining property-specific proportional prediction error distribution information for each predicted value determined by each prediction model; assigning a weight to the predicted value determined by each prediction model by using the property-specific proportional prediction error distribution information; and generating a property-specific weighted average value based on combination of the weight and the predicted value determined by each prediction model and reporting the property-specific weighted average value to minimize prediction error during prediction of the property value.

US Patent:

7065452, Jun 20, 2006

Filed:

Nov 1, 1999

Appl. No.:

09/431469

Inventors:

David M. Armistead - Maynard MA, US
Matthew James Fitzgibbon - Millis MA, US
Mark Andrew Fleming - Cambridge MA, US
James P. Griffith - Weston MA, US
Eunice E. Kim - Framingham MA, US
Joseph L. Kim - Natick MA, US
Michael D. Sintchak - Winchester MA, US
John Allan Thomson - Belmont MA, US
Keith P. Wilson - Hopkinton MA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

G06G 7/48
G06N 7/06

US Classification:

702 27, 703 2

Abstract:

The present invention relates to crystallized molecules and molecular complexes which comprise the active site binding pocket or the FKBP12/FK506 binding pocket of calcineurin or close structural homologues to either binding pocket. This invention also relates to a data storage material encoded with the corresponding structure coordinates of those crystallized molecules or molecular complexes. Such data storage material is capable of displaying such molecules and molecular complexes as a graphical three-dimensional representation on a computer screen. In addition, this invention relates to methods of using the structure coordinates of those molecules or molecular complexes to solve the structure of homologous proteins. This invention also relates to methods of using the structure coordinates to screen and design compounds that bind to calcineurin or homologues thereof.

US Patent:

7305328, Dec 4, 2007

Filed:

Oct 29, 2004

Appl. No.:

10/975337

Inventors:

Mark Fleming - Vienna VA, US
Chionglong Kuo - Arlington VA, US

Assignee:

Fannie Mae - Washington DC

International Classification:

G06F 17/60

US Classification:

702194, 702181, 702182, 705 35

Abstract:

A system and method of accurately predicting and reporting a value of a property based on a weighted average of values predicted by at least two prediction models. The system and method include the steps of accessing predicted values, determined by the prediction models, for the property; determining property-specific proportional prediction error distribution information for each predicted value determined by each prediction model; assigning a weight to the predicted value determined by each prediction model by using the property-specific proportional prediction error distribution information; and generating a property-specific weighted average value based on combination of the weight and the predicted value determined by each prediction model and reporting the property-specific weighted average value to minimize prediction error during prediction of the property value.

US Patent:

7411664, Aug 12, 2008

Filed:

Dec 1, 2003

Appl. No.:

10/726336

Inventors:

David J. Zahniser - Wellesley MA, US
Matthew S. Zelinski - Worthington OH, US
Thomas M. Dolash - Worthington OH, US
Garrick L. Maenle - Columbus OH, US
Mark Fleming - Columbus OH, US
John S. Laudo - Columbus OH, US

Assignee:

Cytyc Corporation - Marlborough MA

International Classification:

G01N 33/48
G01N 21/00
G01N 21/75
G02B 21/06
F21V 9/00

US Classification:

356 39, 359385, 362231, 422 8205, 436 63, 436164

Abstract:

The present invention relates to the analysis of cytological material. Specifically, the invention relates to stains and methods of producing the stains, methods of staining cells for cytological or histological analysis to contrast the nuclear portion of the cell from the cytoplasmic portion, and systems and methods for illuminating a cytological sample. The analysis can be automated or manual.

US Patent:

7538861, May 26, 2009

Filed:

Jul 21, 2008

Appl. No.:

12/177003

Inventors:

David J. Zahniser - Wellesley MA, US
Matthew S. Zelinski - Worthington OH, US
Thomas M. Dolash - Worthington OH, US
Garrick L. Maenle - Columbus OH, US
Mark Fleming - Columbus OH, US
John S. Laudo - Columbus OH, US

Assignee:

Cytyc Corporation - Marlborough MA

International Classification:

G01N 33/48
G02B 21/06
G01N 21/00
G01N 21/75
F21V 9/00

US Classification:

356 39, 359385, 362231, 422 8205, 436 63, 436164

Abstract:

The present invention relates to the analysis of cytological material. Specifically, the invention relates to stains and methods of producing the stains, methods of staining cells for cytological or histological analysis to contrast the nuclear portion of the cell from the cytoplasmic portion, and systems and methods for illuminating a cytological sample. The analysis can be automated or manual.

US Patent:

D595084, Jun 30, 2009

Filed:

Nov 19, 2008

Appl. No.:

29/312880

Inventors:

Paul K. Metaxatos - Swampscott MA, US
Steffen F. Koury - Everett MA, US
Kurtis R. MacLaurin - Arlington MA, US
Robert M. Ulanski - Broadview Heights OH, US
David J. Kolar - Stow OH, US
Stephen P. Rukavina - Rocky River OH, US
Mark F. Fleming - Strongsville OH, US
Anthony M. Ciepiel - Hudson OH, US

Assignee:

Vita-Mix Corporation - Cleveland OH

International Classification:

3100

US Classification:

D 7386, D7378

US Patent:

D595087, Jun 30, 2009

Filed:

Nov 19, 2008

Appl. No.:

29/312881

Inventors:

Paul K. Metaxatos - Swampscott MA, US
Steffen F. Koury - Everett MA, US
Kurtis R. MacLaurin - Arlington MA, US
David J. Kolar - Stow OH, US
Eugene J. Kozlowski - Medina OH, US
Robert M. Ulanski - Broadview Heights OH, US
Mark F. Fleming - Strongsville OH, US
Stephen P. Rukavina - Rocky River OH, US
Anthony M. Ciepiel - Hudson OH, US

Assignee:

Vita-Mix Corporation - Cleveland OH

International Classification:

0702

US Classification:

D 7413, D7412