Mark W Fleming

US Patent:

7527952, May 5, 2009

Filed:

Dec 21, 2006

Appl. No.:

11/645289

Inventors:

Keith P. Wilson - La Jolla CA, US
Michael D. Sintchak - Winchester MA, US
Mark Andrew Fleming - Winchester MA, US
David M. Armistead - Sudbury MA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

C12P 21/06
C12N 9/04

US Classification:

435190, 435 691

Abstract:

The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of IMPDH. Such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to IMPDH or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of IMPDH or close structural homologues of the active site binding pockets. This invention also relates to compounds and pharmaceutical compositions which are inhibitors of IMPDH.

US Patent:

8013610, Sep 6, 2011

Filed:

Dec 20, 2007

Appl. No.:

11/961858

Inventors:

Ray Merewether - La Jolla CA, US
Mark S. Olsson - La Jolla CA, US
Jeffrey A. Praha - San Diego CA, US
Jan Soukup - San Diego CA, US
David A. Cox - San Diego CA, US
Mark F. Fleming - Strongsville OH, US
Lisa E. Latimer - San Diego CA, US
Ryan B. Levin - San Diego CA, US
Michael E. Turgeon - San Diego CA, US
Stephen M. Bench - Carlsbad CA, US
Edward N. Denaci - San Diego CA, US

Assignee:

SeekTech, Inc. - San Diego CA

International Classification:

G01V 3/08

US Classification:

324329, 324228

Abstract:

A high-Q human-portable, battery-powered self-correcting tunable resonator in a transmitter apparatus for inducing alternating currents of high quality in buried conductors to facilitate their location. The transmitter apparatus employs an FET-driven capacitive tuning circuit and a coil design that achieves high precision, high-quality transmission signals, and which is equipped with a high-voltage booster for facilitating fault-localization applications.