Mark S Fleming

US Patent:

6665060, Dec 16, 2003

Filed:

Oct 29, 1999

Appl. No.:

09/430117

Inventors:

David J. Zahniser - Wellesley MA
Matthew S. Zelinski - Worthington OH
Thomas Dolash - Worthington OH
Garrick L. Maenle - Columbus OH
Mark Fleming - Columbus OH
John Laudo - Columbus OH

Assignee:

Cytyc Corporation - Boxborough MA

International Classification:

G01N 3348

US Classification:

356 39, 422 8201, 436164

Abstract:

The present invention relates to the analysis of cytological material. Specifically, the invention relates to stains and methods of producing the stains, methods of staining cells for cytological or histological analysis to contrast the nuclear portion of the cell from the cytoplasmic portion, and systems and methods for illuminating a cytological sample. The analysis can be automated or manual.

US Patent:

7065452, Jun 20, 2006

Filed:

Nov 1, 1999

Appl. No.:

09/431469

Inventors:

David M. Armistead - Maynard MA, US
Matthew James Fitzgibbon - Millis MA, US
Mark Andrew Fleming - Cambridge MA, US
James P. Griffith - Weston MA, US
Eunice E. Kim - Framingham MA, US
Joseph L. Kim - Natick MA, US
Michael D. Sintchak - Winchester MA, US
John Allan Thomson - Belmont MA, US
Keith P. Wilson - Hopkinton MA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

G06G 7/48
G06N 7/06

US Classification:

702 27, 703 2

Abstract:

The present invention relates to crystallized molecules and molecular complexes which comprise the active site binding pocket or the FKBP12/FK506 binding pocket of calcineurin or close structural homologues to either binding pocket. This invention also relates to a data storage material encoded with the corresponding structure coordinates of those crystallized molecules or molecular complexes. Such data storage material is capable of displaying such molecules and molecular complexes as a graphical three-dimensional representation on a computer screen. In addition, this invention relates to methods of using the structure coordinates of those molecules or molecular complexes to solve the structure of homologous proteins. This invention also relates to methods of using the structure coordinates to screen and design compounds that bind to calcineurin or homologues thereof.

US Patent:

7216041, May 8, 2007

Filed:

Oct 2, 2000

Appl. No.:

09/678016

Inventors:

Keith P. Wilson - Hopkinton MA, US
Michael D. Sintchak - Winchester MA, US
Mark Andrew Fleming - Cambridge MA, US
David M. Armistead - Maynard MA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

G06F 19/00

US Classification:

702 27, 702 19, 702 20

Abstract:

The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of IMPDH. Such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to IMPDH or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of IMPDH or close structural homologues of the active site binding pockets. This invention also relates to compounds and pharmaceutical compositions which are inhibitors of IMPDH.

US Patent:

7411664, Aug 12, 2008

Filed:

Dec 1, 2003

Appl. No.:

10/726336

Inventors:

David J. Zahniser - Wellesley MA, US
Matthew S. Zelinski - Worthington OH, US
Thomas M. Dolash - Worthington OH, US
Garrick L. Maenle - Columbus OH, US
Mark Fleming - Columbus OH, US
John S. Laudo - Columbus OH, US

Assignee:

Cytyc Corporation - Marlborough MA

International Classification:

G01N 33/48
G01N 21/00
G01N 21/75
G02B 21/06
F21V 9/00

US Classification:

356 39, 359385, 362231, 422 8205, 436 63, 436164

Abstract:

The present invention relates to the analysis of cytological material. Specifically, the invention relates to stains and methods of producing the stains, methods of staining cells for cytological or histological analysis to contrast the nuclear portion of the cell from the cytoplasmic portion, and systems and methods for illuminating a cytological sample. The analysis can be automated or manual.

US Patent:

7538861, May 26, 2009

Filed:

Jul 21, 2008

Appl. No.:

12/177003

Inventors:

David J. Zahniser - Wellesley MA, US
Matthew S. Zelinski - Worthington OH, US
Thomas M. Dolash - Worthington OH, US
Garrick L. Maenle - Columbus OH, US
Mark Fleming - Columbus OH, US
John S. Laudo - Columbus OH, US

Assignee:

Cytyc Corporation - Marlborough MA

International Classification:

G01N 33/48
G02B 21/06
G01N 21/00
G01N 21/75
F21V 9/00

US Classification:

356 39, 359385, 362231, 422 8205, 436 63, 436164

Abstract:

The present invention relates to the analysis of cytological material. Specifically, the invention relates to stains and methods of producing the stains, methods of staining cells for cytological or histological analysis to contrast the nuclear portion of the cell from the cytoplasmic portion, and systems and methods for illuminating a cytological sample. The analysis can be automated or manual.

US Patent:

D595084, Jun 30, 2009

Filed:

Nov 19, 2008

Appl. No.:

29/312880

Inventors:

Paul K. Metaxatos - Swampscott MA, US
Steffen F. Koury - Everett MA, US
Kurtis R. MacLaurin - Arlington MA, US
Robert M. Ulanski - Broadview Heights OH, US
David J. Kolar - Stow OH, US
Stephen P. Rukavina - Rocky River OH, US
Mark F. Fleming - Strongsville OH, US
Anthony M. Ciepiel - Hudson OH, US

Assignee:

Vita-Mix Corporation - Cleveland OH

International Classification:

3100

US Classification:

D 7386, D7378

US Patent:

D595087, Jun 30, 2009

Filed:

Nov 19, 2008

Appl. No.:

29/312881

Inventors:

Paul K. Metaxatos - Swampscott MA, US
Steffen F. Koury - Everett MA, US
Kurtis R. MacLaurin - Arlington MA, US
David J. Kolar - Stow OH, US
Eugene J. Kozlowski - Medina OH, US
Robert M. Ulanski - Broadview Heights OH, US
Mark F. Fleming - Strongsville OH, US
Stephen P. Rukavina - Rocky River OH, US
Anthony M. Ciepiel - Hudson OH, US

Assignee:

Vita-Mix Corporation - Cleveland OH

International Classification:

0702

US Classification:

D 7413, D7412

US Patent:

7655446, Feb 2, 2010

Filed:

Jun 28, 2006

Appl. No.:

11/478194

Inventors:

Marc Jacobs - Boston MA, US
Koto Hayakawa - Edmonton, CA
Mark Fleming - Cambridge MA, US
John Doran - Medford MA, US
Craig Marhefka - Rockville MD, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

C12N 9/00
G01N 31/00

US Classification:

435183, 436 4

Abstract:

The present invention relates to human Rho-kinase I (ROCK I), ROCK I binding pockets, ROCK I-like binding pockets. More particularly, the present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to ROCK I protein or ROCK I protein homologues, or complexes thereof. The invention also relates to crystallizable compositions and crystals comprising ROCK I kinase domain and ROCK I kinase domain complexed with an inhibitor of that domain. The invention also relates to methods of identifying inhibitors of the ROCK I kinase domain.