Mark D Goulet

US Patent:

7754188, Jul 13, 2010

Filed:

Jun 25, 2004

Appl. No.:

10/559228

Inventors:

H. Donald Burns - Harleysville PA, US
Alex M. Chen - Cranford NJ, US
Raymond E. Gibson - Holland PA, US
Mark T. Goulet - Westfield NJ, US
William K. Hagmann - Westfield PA, US
Terence G. Hamill - Lansdale PA, US
James P. Jewell - Jersey City NJ, US
Linus S. Lin - Westfield NJ, US
Ping Liu - Westfield NJ, US
Andrey V. Peresypkin - Cranford NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 51/00
A61M 36/14

US Classification:

424 165, 424 189

Abstract:

The present invention relates to particular radiolabeled Cannabinoid-1 (CB1) receptor modulators, and methods of using these modulators for labeling and diagnostic imaging of Cannabinoid-1 receptors in mammals, particularly humans. In addition, intermediates useful for the synthesis of the radiolabeled Cannabinoid-1 receptor modulators are also disclosed, as well as the processes for synthesizing the radiolabeled Cannabinoid-1 receptor modulators. Still further, formulations of the radiolabeled Cannabinoid-1 receptor compounds are described.