Mark E. Gurney - Grand Rapids MI 49506 Michael J. Bienkowski - Portage MI 49024 Robert L. Heinrikson - Plainwell MI 49080 Luis A. Parodi - S-11543 Stockholm, SE Riqiang Yan - Kalamazoo MI 49009
International Classification:
C12P 2106
US Classification:
435 691, 4352523, 435325, 4353201, 536 231
Abstract:
The present invention provides the enzyme and enzymatic procedures for cleaving the secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimers disease.
Mark E. Gurney - Grand Rapids MI Michael J. Bienkowski - Portage MI Robert L. Heinrikson - Plainwell MI Luis A. Parodi - Stockholm, SE Riqiang Yan - Kalamazoo MI
Assignee:
Pharmacia Upjohn Company - Kalamazoo MI
International Classification:
C12N 500
US Classification:
435375, 536 231, 536 241, 536 245, 514 44
Abstract:
The present invention provides the enzyme and enzymatic procedures for cleaving the secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimers disease.
Human Sel-10 Polypeptides And Polynucleotides That Encode Them
Mark E. Gurney - Grand Rapids MI Adele M. Pauley - Plainwell MI Jinhe Li - Kalamazoo MI
Assignee:
Pharmacia and Upjohn Company - Kalamazoo MI
International Classification:
C12P 2106
US Classification:
435 691, 4352523, 4353201, 536 231
Abstract:
The present invention provides isolated nucleic acid molecules comprising a polynucleotide encoding either of two alternative splice variants of human sel-10, one of which is expressed in hippocampal cells, and one of which is expressed in mammary cells. The invention also provides isolated sel-10 polypeptides and cell lines which express them in which A processing is altered.
Alzheimers Disease Secretase, App Substrates Therefor, And Uses Therefor
Mark E. Gurney - Grand Rapids MI Michael J. Bienkowski - Portage MI Robert L. Heinrikson - Plainwell MI Luis A. Parodi - Stockholm, SE Riqiang Yan - Kalamazoo MI
Assignee:
Pharmacia Upjohn Company - Kalamazoo MI
International Classification:
G01N 3353
US Classification:
435 71, 530350, 530300
Abstract:
The present invention provides the enzyme and enzymatic procedures for cleaving the secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimers disease.
Method Of Identifying Agents That Inhibit App Processing Activity
Mark E. Gurney - Grand Rapids MI Michael J. Bienkowski - Portage MI Robert L. Heinrikson - Plainwell MI Luis A. Parodi - Stockkholm, SE Riqiang Yan - Kalamazoo MI
Mark E. Gurney - Grand Rapids MI Michael J. Bienkowski - Portage MI Robert L. Heinrikson - Plainwell MI Luis A. Parodi - Stockholm, SE Riqiang Yan - Kalamazoo MI
Assignee:
Pharmacia Upjohn Company - Kalamazoo MI
International Classification:
C12Q 137
US Classification:
435 24, 435 23, 435135, 435212, 530350, 424450
Abstract:
The present invention provides the enzyme and enzymatic procedures for cleaving the secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimers disease.
Human Sel-10 Polypeptides And Polynucleotides That Encode Them
Mark E. Gurney - Grand Rapids MI Adele M. Pauley - Plainwell MI Jinhe Li - Kalamazoo MI
Assignee:
Pharmacia and Upjohn Company - Kalamazoo MI
International Classification:
C07K 1700
US Classification:
530350, 530300
Abstract:
The present invention provides isolated nucleic acid molecules comprising a polynucleotide encoding either of two alternative splice variants of human sel-10, one of which is expressed in hippocampal cells, and one of which is expressed in mammary cells. The invention also provides isolated sel-10 polypeptides and cell lines which express them in which A processing is altered.
Alzheimers Disease Secretase, App Substrates Therefor, And Uses Thereof
Mark E. Gurney - Grand Rapids MI Michael J. Bienkowski - Portage MI Robert L. Heinrikson - Plainwell MI Luis A. Parodi - Stockholm, SE Riqiang Yan - Kalamazoo MI
Assignee:
Pharmacia Upjohn Company - Kalamazoo MI
International Classification:
C07K 1700
US Classification:
530350, 435219
Abstract:
The present invention provides the enzyme and enzymatic procedures for cleaving the secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimers disease.
Mark Gurney (1975-1979), Laura Quinn (1969-1973), Arda Itez (1985-1989), Frank Lipari (1990-1994), Christopher Wirt (1996-2000), Allison Patti (1995-1999)