Mark L Herman

US Patent:

7815937, Oct 19, 2010

Filed:

Jun 21, 2002

Appl. No.:

10/176135

Inventors:

Naima Mezaache - McLean VA, US
Steven E. Frisbee - Reston VA, US
Patrick B. Woodall - Culpeper VA, US
Mark R. Herman - Nokesville VA, US
Djelila Mezaache - Aldie VA, US

Assignee:

Biovail Laboratories International SRL - St. Michael

International Classification:

A61K 9/20

US Classification:

424465, 424458

Abstract:

The invention provides a composition useful for making oral dosage forms capable of dissolving in the mouth in less than 40 seconds without the need for a conventional super disintegrant and having a friability of less than 1%; wherein the composition includes liquiflash particles and an excipient mass. A preferred excipient mass according to the invention contains a directly compressible inorganic salt; a cellulose derivative or a combination of a directly compressible inorganic salt and a cellulose derivative. Preferably, the liquiflash particles and the excipient mass are combined in proportions such that the active ingredient remains substantially within the microspheres when the composition is compressed to obtain a dosage form having a hardness of 20 to 50 N. The compositions of the invention allow for the fabrication of oral dosages having improved hardness and friability.

US Patent:

20050021522, Jan 27, 2005

Filed:

May 14, 2004

Appl. No.:

10/845423

Inventors:

Mark Herman - Potomac MD, US
Melissa Hathaway - Vienna VA, US
Melvin Sobotka - Ellicott City MD, US

International Classification:

G06F007/00

US Classification:

707010000, 707104100

Abstract:

The present invention is directed to an apparatus, method and computer apparatus for evaluating a network of entities and assets.

US Patent:

20100178353, Jul 15, 2010

Filed:

Mar 24, 2010

Appl. No.:

12/730339

Inventors:

Naima MEZAACHE - McLean VA, US
Steven E. Frisbee - Reston VA, US
Patrick B. Woodall - Culpeper VA, US
Mark R. Herman - Nokesville VA, US

Assignee:

BIOVAIL LABORATORIES INTERNATIONAL S.R.L. - St. Michael

International Classification:

A61K 9/14
A61K 31/138
A61K 31/4525
A61K 31/437
A61P 25/24

US Classification:

424494, 424497, 514651, 514321, 514300, 424490

Abstract:

The invention provides a composition useful for making oral dosage forms capable of dissolving in the mouth in less than 40 seconds without the need for a conventional super disintegrant and having a friability of less than 1%; wherein the composition includes liquiflash particles and an excipient mass. A preferred excipient mass according to the invention contains a directly compressible inorganic salt; a cellulose derivative or a combination of a directly compressible inorganic salt and a cellulose derivative. Preferably, the liquiflash particles and the excipient mass are combined in proportions such that the active ingredient remains substantially within the microspheres when the composition is compressed to obtain a dosage form having a hardness of 20 to 50 N. The compositions of the invention allow for the fabrication of oral dosages having improved hardness and friability.

US Patent:

20120082729, Apr 5, 2012

Filed:

Dec 8, 2011

Appl. No.:

13/314592

Inventors:

Naima MEZAACHE - McLean VA, US
Steven E. Frisbee - Reston VA, US
Patrick B. Woodall - Culpeper VA, US
Mark R. Herman - Nokesville VA, US

Assignee:

VALEANT INTERNATIONAL (BARBADOS) SRL - Welches

International Classification:

A61K 9/14
A61K 47/02
A61K 47/10
A61K 31/138
A61K 31/4525
A61K 31/437
A61P 11/14
A61P 11/02
A61P 3/02
A61P 1/10
A61P 1/04
A61P 3/06
A61P 9/06
A61P 29/00
A61P 11/00
A61P 25/22
A61P 9/08
A61P 1/00
A61P 11/06
A61P 11/12
A61P 3/04
A61P 7/10
A61P 1/12
A61P 35/00
A61P 1/08
A61P 25/20
A61P 9/12
A61P 25/18
A61P 3/08
A61P 3/10
A61P 31/00
A61P 25/06
A61P 25/08
A61P 7/02
A61K 47/38

US Classification:

424494, 514781, 514770, 424490, 424497, 514651, 514321, 514300

Abstract:

The invention provides a composition useful for making oral dosage forms capable of dissolving in the mouth in less than 40 seconds without the need for a conventional super disintegrant and having a friability of less than 1%; wherein the composition includes liquiflash particles and an excipient mass. A preferred excipient mass according to the invention contains a directly compressible inorganic salt; a cellulose derivative or a combination of a directly compressible inorganic salt and a cellulose derivative. Preferably, the liquiflash particles and the excipient mass are combined in proportions such that the active ingredient remains substantially within the microspheres when the composition is compressed to obtain a dosage form having a hardness of 20 to 50 N. The compositions of the invention allow for the fabrication of oral dosages having improved hardness and friability.

US Patent:

60834307, Jul 4, 2000

Filed:

Apr 29, 1996

Appl. No.:

8/642026

Inventors:

Richard C. Fuisz - McLean VA
Garry L. Myers - Kingsport TN
Robert K. Yang - Flushing NY
Mark R. Herman - Nokesville VA
Whitney S. Cavanagh - Reston VA
John R. Sisak - Fairfax VA
Andrea S. Brothers - Chantilly VA

Assignee:

Fuisz Technologies Ltd. - Chantilly VA

International Classification:

A61K 914

US Classification:

264 5

Abstract:

The present invention is a process and apparatus for making a dosage unit by direct tableting of shearlite particles. The present invention also includes the dosage unit itself. Shearlite particles, which are prepared by subjecting a feedstock material to liquiflash processing, can be directly fed from a shearlite device to a tableting apparatus without the necessity of any intermediate steps or additional ingredients to facilitate flowability or tablet formation.

US Patent:

59651644, Oct 12, 1999

Filed:

Apr 29, 1996

Appl. No.:

8/642027

Inventors:

Richard C. Fuisz - Great Falls VA
Robert K. Yang - Flushing NY
Whitney S. Cavanagh - Reston VA
Garry L. Myers - Reston VA
Mark R. Herman - Nokesville VA

Assignee:

Fuisz Technologies Ltd. - Chantilly VA

International Classification:

A61K 914

US Classification:

424489

Abstract:

A recipient-dosage delivery system including shearlite particles of a bio-affecting agent for delivery to a recipient. The particles are provided in a metered dose and are packaged in a bi-functional vessel. The particles are produced under liquiflash conditions and exhibit sufficient flowability so as to allow administration of the metered dose to the recipient under the force of gravity.