Mark A Lockwood

US Patent:

7189856, Mar 13, 2007

Filed:

Nov 7, 2002

Appl. No.:

10/289924

Inventors:

Gideon Shapiro - Gainesville FL, US
Michael G. Natchus - Alpharetta GA, US
Mark A. Lockwood - Alpharetta GA, US
Simona Jurczyk - Gainesville FL, US

International Classification:

C07D 27/104
A61K 31/41

US Classification:

548125, 514359, 514396

Abstract:

Non-peptide somatostatin receptor ligands with conformationally restricted side chains exhibiting high binding affinity toward somatostatin receptors are provided. The compounds exhibit a high selectivity and act as agonists at human subtype 2 somatostatin receptors. The compounds are long acting for advantageous use as medicaments in peripheral diseases where somatostatinergic therapy is indicated. Furthermore, many of the compounds are lipophilic and are particularly useful for treating central nervous system and ophthalmic diseases where penetration of the blood brain and blood retinal barriers is required. It is a further object to describe the preferred stereoisomers of these somatostatin agonists and processes for their preparation. Further objects will become apparent from reading the following description.

US Patent:

7932245, Apr 26, 2011

Filed:

Oct 22, 2003

Appl. No.:

10/691095

Inventors:

Youssef L. Bennani - Shaker Heights OH, US
William H. Bunnelle - Mundelein IL, US
Sanjay R. Chemburkar - Gurnee IL, US
Jinhua Chen - Gurnee IL, US
Michael J. Dart - Highland Park IL, US
Dilinie P. Fernando - Gurnee IL, US
Yi-Yin Ku - Buffalo Grove IL, US
Mark Lockwood - Alpharetta GA, US
Lei Wang - Libertyville IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 31/397
A61K 31/535
A61K 31/4965
A61K 31/445

US Classification:

51421001, 5142375, 5142272, 51425501, 514317, 514423

Abstract:

The present invention relates to the use of compounds of formula (I).

US Patent:

8338448, Dec 25, 2012

Filed:

Mar 30, 2009

Appl. No.:

12/414352

Inventors:

Michael P. Clark - Concord MA, US
Florence F. Wagner - Ashland MA, US
Brandon C. Doroh - Duluth GA, US
Tricia L. Johnson - Union City GA, US
Yesim Altas Tahirovic - Decatur GA, US
Lawrence Wilson - Atlanta GA, US
John M. Wiseman - Atlanta GA, US
Jason W. Skudlarek - Suwanee GA, US
Mark A. Lockwood - Alpharetta GA, US
Michael G. Natchus - Alpharetta GA, US

Assignee:

Altiris Therapeutics, Inc. - Atlanta GA

International Classification:

A61K 31/44
C07D 491/00

US Classification:

514292, 546 85

Abstract:

The invention provides compounds of Formula (I).

US Patent:

20040077616, Apr 22, 2004

Filed:

Oct 22, 2002

Appl. No.:

10/277266

Inventors:

Youssef Bennani - Shaker Heights OH, US
William Bunnelle - Mundelein IL, US
Sanjay Chemburkar - Gurnee IL, US
Jinhua Chen - Gurnee IL, US
Michael Dart - Highland Park IL, US
Dilinie Fernando - Gurnee IL, US
Yi-Yin Ku - Buffalo Grove IL, US
Mark Lockwood - Alpharetta GA, US
Lei Wang - Libertyville IL, US

International Classification:

A61K031/33
A61K031/397
A61K031/55
A61K031/54
A61K031/537
A61K031/495
A61K031/401
A61K031/165
A61K031/215

US Classification:

514/183000, 514/227500, 514/237500, 514/255010, 514/210170, 514/217110, 514/317000, 514/423000, 514/531000, 514/624000

Abstract:

The present invention relates to the use of compounds of formula (I) for the treatment of epilepsy, bipolar disorder, psychiatric disorders, migraine, pain, or movement disorders, and to provide neuroprotection.

US Patent:

20130172330, Jul 4, 2013

Filed:

Nov 15, 2012

Appl. No.:

13/677944

Inventors:

Altiris Therapeutics, Inc - Atlanta GA, US
Florence F. Wagner - Ashland MA, US
Michael G. Natchus - Alpharetta GA, US
Brandon C. Doroh - Duluth GA, US
Tricia L. Johnson - Union City GA, US
Yesim Altas Tahirovic - Decatur GA, US
Lawrence Wilson - Atlanta GA, US
John M. Wiseman - Atlanta GA, US
Jason W. Skudlarck - Suwanee GA, US
Mark A. Lockwood - Alpharetta GA, US

Assignee:

ALTIRIS THERAPEUTICS, INC. - Atlanta GA

International Classification:

A61K 31/541
C07D 401/12
A61K 31/4709
A61K 45/06
A61K 31/496
A61K 31/437
A61K 31/506
C07D 471/04
A61K 31/5377

US Classification:

5142282, 546 87, 514292, 546171, 514314, 544126, 5142352, 544363, 51425303, 544331, 514275, 544 582, 544121, 544 584

Abstract:

The invention provides compounds of Formula (I)and pharmaceutically acceptable salts, solvates, tautomers, stereoisomers, and/or esters thereof. These compounds, and pharmaceutical composition comprising such compounds are useful treating or preventing HIV infections, and in treating proliferative disorders such as inhibiting the metastasis of various cancers

US Patent:

20130210785, Aug 15, 2013

Filed:

Feb 14, 2013

Appl. No.:

13/767106

Inventors:

Emory University - , US
Mark A. Lockwood - Johns Creek GA, US
Dennis C. Liotta - Atlanta GA, US
Michael G. Natchus - Alpharetta GA, US
Donald G. Stein - Atlanta GA, US
Iqbal Sayeed - Atlanta GA, US

Assignee:

EMORY UNIVERSITY - Atlanta GA

International Classification:

A61K 31/58
C07J 43/00
A61K 45/06
C07J 41/00
A61K 31/57

US Classification:

514171, 552520, 514169, 514177, 552607, 544154, 514176, 548528, 544380, 546285

Abstract:

This disclosure relates to progesterone derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed herein and uses for managing inflammation resulting from traumatic brain injury or stroke.

US Patent:

20220235092, Jul 28, 2022

Filed:

Feb 4, 2022

Appl. No.:

17/592870

Inventors:

- Atlanta GA, US
Mark A. Lockwood - Johns Creek GA, US
Dennis C. Liotta - Atlanta GA, US
Michael G. Natchus - Alpharetta GA, US
Donald G. Stein - Atlanta GA, US
Iqbal Sayeed - Atlanta GA, US

Assignee:

EMORY UNIVERSITY - Atlanta GA

International Classification:

C07J 41/00
A61K 31/58
A61K 31/57
A61K 45/06
C07J 43/00

Abstract:

This disclosure relates to progesterone derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed herein and uses for managing inflammation resulting from traumatic brain injury or stroke.

US Patent:

20210395294, Dec 23, 2021

Filed:

Jun 28, 2021

Appl. No.:

17/360614

Inventors:

- Atlanta GA, US
Mark Andrew Lockwood - Johns Creek GA, US
Michael G. Natchus - Alpharetta GA, US
Dennis C. Liotta - Atlanta GA, US
Donald G. Stein - Atlanta GA, US
Iqbal Sayeed - Atlanta GA, US

International Classification:

C07J 41/00
A61K 45/06
A61K 31/57
A61K 31/661
C07J 43/00
C07J 51/00
A61K 31/58

Abstract:

This disclosure relates to progesterone phophate derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed herein and uses for managing inflammation such as those resulting from traumatic brain injury or stroke.