Mark E Lundstrom

US Patent:

6404107, Jun 11, 2002

Filed:

Feb 26, 1999

Appl. No.:

09/261475

Inventors:

Kenneth B. Lazarus - Concord MA
Mark E. Lundstrom - Seattle WA
Jeffrey W. Moore - Arlington MA
Edward Crawley - Cambridge MA
Farla Russo - Brookline MA
Shoko Yoshikawa - Cambridge MA

Assignee:

Active Control eXperts, Inc. - Cambridge MA

International Classification:

H01L 4108

US Classification:

310328, 310330, 310334, 310366

Abstract:

A modular actuator assembly includes one or more plates or elements of electro-active material bonded to an electroded sheet, preferably by a structural polymer to form a card. The card is sealed, and may itself constitute a practical device, such as a vane, shaker, stirrer, lever, pusher or sonicator for direct contact with a solid or immersion in a fluid, or may be bonded by a stiff adhesive to make a surface-to-surface mechanical coupling with a solid workpiece, device, substrate machine or sample. The structural polymer provides a bending stiffness such that the thin plate does not deform to its breaking point, and a mechanical stiffness such that shear forces are efficiently coupled from the plate to the workpiece. In further embodiments, the card may include active circuit elements for switching, powering or processing signals, and/or passive circuit elements for filtering, matching or damping signals, so that few or no connections to outside circuitry are required. The actuator assembly can be manufactured in quantity, to provide a versatile actuator with uniform mechanical and actuation characteristics, that introduces negligible mass loading to the workpiece.

US Patent:

6420819, Jul 16, 2002

Filed:

Jan 27, 1994

Appl. No.:

08/188145

Inventors:

Kenneth B. Lazarus - Boston MA
Mark E. Lundstrom - Cambridge MA
Jeffrey W. Moore - Concord MA
Edward F. Crawley - Cambridge MA

Assignee:

Active Control EXperts, Inc. - Cambridge MA

International Classification:

H01L 4108

US Classification:

310330, 310328, 310332, 310340, 310366

Abstract:

A modular actuator assembly includes one or more plates or elements of electro-active material bonded to an electroded sheet, preferably by a structural polymer to form a card. The card is sealed, and may itself constitute a practical device, such as a vane, shaker, stirrer, lever, pusher or sonicator for direct contact with a solid or immersion in a fluid, or may be bonded by a stiff adhesive to make a surface-to-surface mechanical coupling with a solid workpiece,device, substrate, machine or sample. The structural polymer provides a bending stiffness such that the thin plate does not deform to its breaking point, and a mechanical stiffness such that shear forces are efficiently coupled from the plate to the workpiece. In further embodiments, the card may include active circuit elements for switching, powering or processing signals, and/or passive circuit elements for filtering, matching or damping signals, so that few or no connections to outside circuitry are required. The actuator assembly can be manufactured in quantity, to provide a versatile actuator with uniform mechanical and actuation characteristics, that introduces negligible mass loading to the workpiece.

US Patent:

6781285, Aug 24, 2004

Filed:

Apr 27, 1999

Appl. No.:

09/300137

Inventors:

Kenneth B. Lazarus - Concord MA
Mark E. Lundstrom - Seattle WA
Jeffrey W. Moore - Arlington MA
Edward Crawley - Cambridge MA
Farla Russo - Brookline MA
Shoko Yoshikawa - Cambridge MA
Eric Fitch - Medford MA

Assignee:

Cymer, Inc. - San Diego CA

International Classification:

H01L 4108

US Classification:

310332, 310340

Abstract:

A modular actuator assembly includes one or more plates or elements of electro-active material bonded to an electroded sheet, preferably by a structural polymer to form a card. The card is sealed, and may itself constitute a practical device, such as a vane, shaker, stirrer, lever, pusher or sonicator for direct contact with a solid or immersion in a fluid, or may be bonded by a stiff adhesive to make a surface-to-surface mechanical coupling with a solid workpiece, device, substrate machine or sample. The structural polymer provides a bending stiffness such that the thin plate does not deform to its breaking point, and a mechanical stiffness such that shear forces are efficiently coupled from the plate to the workpiece. In further embodiments, the card may include active circuit elements for switching, powering or processing signals, and/or passive circuit elements for filtering, matching or damping signals, so that few or no connections to outside circuitry are required. The actuator assembly can be manufactured in quantity, to provide a versatile actuator with uniform mechanical and actuation characteristics, that introduces negligible mass loading to the workpiece.

US Patent:

7178378, Feb 20, 2007

Filed:

Aug 28, 2003

Appl. No.:

10/651338

Inventors:

Ed Crawley - Cambridge MA, US
Mark Lundstrom - Boston MA, US
Brett Masters - Belmont MA, US
Alok Srivastava - Alston MA, US
Martin Schmidt - Reading MA, US
Michael Miller - Hollis NH, US

Assignee:

BioScale, Inc. - Cambridge MA

International Classification:

G01N 23/036

US Classification:

73 2406, 73 2401, 73 6453

Abstract:

The disclosed sensor chip includes a substrate and a moving member coupled to the substrate and disposed for movement relative to the substrate. The moving member moves relative to the substrate in a first direction and in a second direction in response to movement of the substrate. The first direction is different than the second direction. The moving member includes a plurality of receptors. The receptors are configured for selectively binding to a first measurand.

US Patent:

7300631, Nov 27, 2007

Filed:

Jul 18, 2005

Appl. No.:

11/183484

Inventors:

Michael F. Miller - Hollis NH, US
Brett P. Masters - Watertown MA, US
Mark E. Lundstrom - Boston MA, US

Assignee:

BioScale, Inc. - Cambridge MA

International Classification:

G01N 15/06
B32B 27/00
B32B 27/12
G01N 33/553

US Classification:

422 8201, 422 681, 436526

Abstract:

A system for detecting an analyte in a sample includes a resonant sensor that has a sensor surface coated with the capture agent. A plurality of magnetic particles, each of which is coated with a capture agent having an affinity for the analyte, is combined with the sample to form a plurality of analyte-particle complexes. The system also includes a transport arrangement for transporting the sample to the sensor surface, and a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of analyte-particle complexes that are bound to the sensor surface.

US Patent:

7598094, Oct 6, 2009

Filed:

May 2, 2006

Appl. No.:

11/417005

Inventors:

Brett P. Masters - Watertown MA, US
Michael Miller - Hollis NH, US
Mark Lundstrom - Boston MA, US

Assignee:

BioScale, Inc. - Cambridge MA

International Classification:

G01N 33/553
B32B 27/00
B32B 27/12

US Classification:

436526, 436148, 435 71, 435 794, 4352872, 4352873, 422 681, 422 81, 422 8213, 422100, 422104

Abstract:

Methods for detecting cardiac injury by detecting one or more cardiac markers are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for a cardiac marker, is combined with the sample to form a plurality of analyte-particle complexes. The system also includes a transport arrangement for transporting the sample to the sensor surface, and optionally a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of analyte-particle complexes that are bound to the sensor surface.

US Patent:

7611908, Nov 3, 2009

Filed:

May 2, 2006

Appl. No.:

11/416624

Inventors:

Michael Miller - Hollis NH, US
Brett P. Masters - Watertown MA, US
Mark Lundstrom - Boston MA, US
Alok Srivastava - San Francisco CA, US
Wayne U. Wang - Cambridge MA, US

Assignee:

BioScale, Inc. - Cambridge MA

International Classification:

G01N 33/553
B32B 27/00
B32B 27/12

US Classification:

436526, 436523, 436525, 436149, 435 71, 435 793, 4352872, 4352873, 422 681, 422 81, 422 8213, 422100, 422104

Abstract:

Methods for therapeutic drug monitoring are provided. A plurality of particles, each of which is coated with a capture agent capable of binding a therapeutic drug of choice is combined with the sample to form a plurality of therapeutic drug-particle complexes. The system also includes a transport arrangement for transporting the sample and/or particles to the sensor surface, and optionally a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of therapeutic drug-particle complexes that are bound to the sensor surface.

US Patent:

7615381, Nov 10, 2009

Filed:

May 2, 2006

Appl. No.:

11/417000

Inventors:

Brett P. Masters - Watertown MA, US
Michael Miller - Hollis NH, US
Vishal K. Gulati - London, GB
Mark Lundstrom - Boston MA, US
Alok Srivastava - San Francisco CA, US
Wayne U. Wang - Cambridge MA, US

Assignee:

BioScale, Inc. - Cambridge MA

International Classification:

G01N 33/553
B32B 27/00
B32B 27/12

US Classification:

436526, 436523, 436525, 436168, 435 71, 435 794, 4352872, 4352873, 422 681, 422 81, 422 8213, 422100, 422104

Abstract:

Methods for detecting estradiol and metabolites thereof in a sample are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for estradiol, is combined with the sample to form a plurality of estradiol-particle complexes. The system also includes a transport arrangement for transporting the sample and/or particles to the sensor surface, and optionally a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of estradiol-particle complexes that are bound to the sensor surface.