Mark Murdock

US Patent:

20200069738, Mar 5, 2020

Filed:

Mar 2, 2018

Appl. No.:

16/490056

Inventors:

- Pittsburgh PA, US
George S. Hussey - Cranberry Twp PA, US
Lindsey Tamiko Saldin - El Segundo CA, US
Mark Hikaru Murdock - Pittsburgh PA, US

Assignee:

University of Pittsburgh - Of the Commonwealth System of Higher Education - Pittsburgh PA

International Classification:

A61K 35/22
A61P 35/00
A61K 35/37
A61K 45/06

Abstract:

Methods are disclosed for reducing the proliferation of a tumor cell, increasing apoptosis of a tumor cell, and/or decreasing migration of a tumor cell. These methods include contacting the tumor cell with an effective amount of solubilized ECM or a soluble fraction of extracellular matrix (ECM), thereby reducing the proliferation of the tumor cell, increasing apoptosis of the tumor cell, and/or decreasing migration of the tumor cell. Methods are also disclosed for treating a subject with a tumor. The methods include administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a soluble fraction of an ECM and a pharmaceutically acceptable carrier, thereby treating the tumor in the subject. In specific non-limiting examples, the tumor is a glioma and/or the ECM hydrogel is a urinary bladder ECM hydrogel.