Mark G Obukowicz from 7621 Highway X, Clearwater Lk, WI 54562, age 69, Phone: (715)5464049

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Location:

Saint Louis, MO

Industry:

Pharmaceuticals

Use Of -Linolenic Acid Metabolites For Treatment Or Prevention Of Cancer
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US Patent:

6340705, Jan 22, 2002
Filed:

Sep 10, 1999
Appl. No.:

09/393790
Inventors:

Mark Obukowicz - Kirkwood MO
Ayman Kabakibi - Creve Coeur MO
Susan L. Green - St. Ann MO
Lisa M. Olson - Richmond Heights MO
Julie Lindemann - El Cerrito CA
Assignee:

Monsanto Technology, LLC - St. Louis MO
International Classification:

A61K 3120
US Classification:

514560
Abstract:

Cancer in a mammal can be treated or prevented by administering to a mammal in need thereof a cancer inhibiting amount of metabolite(s) of -linolenic acid, such as stearidonic acid (18:4 n-3), eicosatetraenoic acid (20:4 n-3), docosaptentaenic acid (22:5 n-3) and mixtures thereof, especially metabolites including stearidonic acid.

Substituted Benzopyran Analogs For The Treatment Of Inflammation
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US Patent:

6492390, Dec 10, 2002
Filed:

May 24, 2001
Appl. No.:

09/865177
Inventors:

Jeffery S Carter - Chesterfield MO
Mark G Obukowicz - Kirkwood MO
Balekudru Devadas - Chesterfield MO
John J Talley - St. Louis MO
David L Brown - Chesterfield MO
Matthew J Graneto - Chesterfield MO
Stephen R Bertenshaw - Cheshire CT
Srinivasan Raj Nagarajan - Chesterfield MO
Cathleen E Hanau - St. Louis MO
Susan J Hartmann - Kirkwood MO
Cindy L Ludwig - St. Louis MO
Suzanne Metz - Chesterfield MO
Donald E Korte - Mundelein IL
Assignee:

G.D. Searle Co. - Chicago IL
International Classification:

A61K 3138
US Classification:

514311, 514432, 514456, 514569, 546170, 549 57, 549405, 562490
Abstract:

A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula Iâ wherein X, A , A , A , A , R, Râ, R and R are as described in the specification.

Substituted Benzopyran Derivatives For The Treatment
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US Patent:

6806288, Oct 19, 2004
Filed:

Feb 2, 2000
Appl. No.:

09/496695
Inventors:

Jeffery S Carter - Chesterfield MO
Mark G Obukowicz - Kirkwood MO
Balekudru Devadas - Chesterfield MO
John J Talley - St. Louis MO
David L Brown - Chesterfield MO
Matthew J Graneto - Chesterfield MO
Stephen R Bertenshaw - Cheshire CT
Srinivasan Raj Nagarajan - Chesterfield MO
Cathleen E Hanau - Chesterfield MO
Susan J Hartman - Kirkwood MO
Cindy L Ludwig - St. Louis MO
Suzanne Metz - Chesterfield MO
Donald E Korte - Mundelein IL
Assignee:

G.D. Searle Co. - Chicago IL
International Classification:

A61K 31385
US Classification:

514434, 549 23
Abstract:

A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula Iâ wherein X, A , A , A , A , R, Râ, R and R are as described in the specification.

Substituted Benzopyran Derivatives For The Treatment Of Inflammation
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US Patent:

7109211, Sep 19, 2006
Filed:

Aug 19, 2004
Appl. No.:

10/922036
Inventors:

Jeffery S Carter - Chesterfield MO, US
Mark G Obukowicz - Kirkwood MO, US
Balekudru Devadas - Chesterfield MO, US
John J Talley - St. Louis MO, US
David L Brown - Chesterfield MO, US
Matthew J Graneto - Chesterfield MO, US
Stephen R Bertenshaw - Cheshire CT, US
Srinivasan Raj Nagarajan - Chesterfield MO, US
Cathleen E Hanau - Chesterfield MO, US
Susan J Hartmann - Kirkwood MO, US
Cindy L Ludwig - St. Louis MO, US
Suzanne Metz - Chesterfield MO, US
Donald E Korte - Mundelein IL, US
Assignee:

Pharmacia Corporation (of Pfizer, Inc.) - Chesterfield MO
International Classification:

A61K 31/47
C07D 211/30
US Classification:

514311, 546169, 546170
Abstract:

A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′.

Substituted Benzopyran Derivatives For The Treatment Of Inflammation
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US Patent:

7138411, Nov 21, 2006
Filed:

Nov 22, 2002
Appl. No.:

10/303150
Inventors:

Jeffery S Carter - Chesterfield MO, US
Mark G Obukowicz - Kirkwood MO, US
Balekudru Devadas - Chesterfield MO, US
John J Talley - St. Louis MO, US
David L Brown - Chesterfield MO, US
Matthew J Graneto - Chesterfield MO, US
Stephen R Bertenshaw - Cheshire CT, US
Srinivasan Raj Nagarajan - Chesterfield MO, US
Cathleen E Hanau - St. Louis MO, US
Susan J Hartmann - Kirkwood MO, US
Cindy L Ludwig - St. Louis MO, US
Suzanne Metz - Chesterfield MO, US
Donald E Korte - Mundelein IL, US
Assignee:

G.D. Searle & Co. - St. Louis MO
International Classification:

A61K 31/47
A61K 31/38
A61K 31/35
C07D 307/77
C07D 335/04
US Classification:

514311, 514432, 514456, 514569, 549456, 549 23, 549 57, 562490, 546156
Abstract:

A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′.