Mark Daniel Reeves

US Patent:

6734014, May 11, 2004

Filed:

Jan 7, 1999

Appl. No.:

09/117764

Inventors:

Patrick Hwu - Rockville MD
Mark Reeves - New York NY
Steven A. Rosenberg - Potomac MD

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

A61K 4800

US Classification:

435325, 4353201, 435455, 424 932, 424 9321, 514 44

Abstract:

Recombinant dendritic cells are made by transforming a stem cell and differentiating the stem cell into a dendritic cell. The resulting dendritic cell is an antigen presenting cell which activates T cells against MHC class I-antigen targets. Kits, assays and therapeutics are based upon the activation of T cells by the recombinant dendritic cell. Cancer, viral infections and parasitic infections are all ameliorated by the recombinant dendritic cells, or corresponding activated T cells. Therapeutic compositions and pharmaceutical compositions are provided.

US Patent:

7378277, May 27, 2008

Filed:

Jun 26, 2003

Appl. No.:

10/607327

Inventors:

Patrick Hwu - Rockville MD, US
Mark Reeves - Grand Terrace CA, US
Steven A. Rosenberg - Potomac MD, US

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

C12N 15/00
C12N 15/74
C12N 5/00
C12N 5/08

US Classification:

435455, 4353201, 435325, 435372, 435377, 424 9321, 424 9371

Abstract:

Recombinant dendritic cells are made by transforming a stem cell and differentiating the stem cell into a dendritic cell. The resulting dendritic cell is an antigen presenting cell which activates T cells against MHC class I-antigen targets. Kits, assays and therapeutics are based upon the activation of T cells by the recombinant dendritic cell. Cancer, viral infections and parasitic infections are all ameliorated by the recombinant dendritic cells, or corresponding activated T cells. Therapeutic compositions and pharmaceutical compositions are provided.

US Patent:

7735146, Jun 8, 2010

Filed:

Jan 26, 2006

Appl. No.:

11/795687

Inventors:

Akos Vertes - Reston VA, US
Mark E. Reeves - Arlington VA, US
Fatah Kashanchi - North Bethesda MD, US

Assignee:

The George Washington University - Washington DC

International Classification:

H01J 49/40

US Classification:

850 9, 250281, 250282, 250287, 250288, 850 21, 850 30, 850 32

Abstract:

A system and method for analyzing and imaging a sample containing molecules of interest combines modified MALDI mass spectrometer and SNOM devices and techniques, and includes: (A) an atmospheric-pressure or near-atmospheric-pressure ionization region; (B) a sample holder for holding the sample; (C) a laser for illuminating said sample; (D) a mass spectrometer having at least one evacuated vacuum chamber; (E) an atmospheric pressure interface connecting said ionization region and said mass spectrometer; (F) a scanning near-field optical microscopy instrument comprising a near-field probe for scanning the sample; a vacuum capillary nozzle for sucking in particles which are desorbed by said laser, the nozzle being connected to an inlet orifice of said atmospheric pressure interface; a scanner platform connected to the sample holder, the platform being movable to a distance within a near-field distance of the probe; and a controller for maintaining distance information about a current distance between said probe and said sample; (G) a recording device for recording topography and mass spectrum measurements made during scanning of the sample with the near-field probe; (H) a plotting device for plotting said topography and mass spectrum measurements as separate x-y mappings; and (I) an imaging device for providing images of the x-y mappings.

US Patent:

7829139, Nov 9, 2010

Filed:

Feb 24, 2006

Appl. No.:

11/886464

Inventors:

Mark Reeves - Arlington VA, US
Jiajie Diao - Springfield VA, US

Assignee:

The George Washington University - Washington DC

International Classification:

B05D 1/24
B05D 5/00
B05D 1/18

US Classification:

427197, 4274301, 427180, 427201, 427256

Abstract:

A new method of making self-assembled nanoparticle wires involves:.

US Patent:

8286260, Oct 9, 2012

Filed:

May 19, 2010

Appl. No.:

12/783122

Inventors:

Akos Vertes - Reston VA, US
Mark E. Reeves - Arlington VA, US
Fatah Kashanchi - North Bethesda MD, US

Assignee:

The George Washington University - Washington DC

International Classification:

H01J 49/40

US Classification:

850 9, 850 30, 850 31, 250281, 250282, 250288

Abstract:

A system and method for analyzing and imaging a sample containing molecules of interest combines modified MALDI mass spectrometer and SNOM devices and techniques and includes: (A) an atmospheric pressure or near-atmospheric pressure ionization region; (B) a sample holder for holding the sample; (C) a laser for illuminating said sample; (D) a mass spectrometer having at least one evacuated chamber; (E) an atmospheric pressure interface for connecting said ionization region and said mass spectrometer; (F) a scanning near-field optical microscopy instrument; (G) a recording device for recording topography and mass spectrum measurements made during scanning of the sample with the near-field probe; (H) a plotting device for plotting said topography and mass spectrum measurements as separate x-y mappings; and (I) an imaging device for providing images of the x-y mappings.

US Patent:

20090263365, Oct 22, 2009

Filed:

Oct 25, 2007

Appl. No.:

11/978019

Inventors:

Patrick Hwu - Rockville MD, US
Mark Reeves - Grand Terrace CA, US
Steven A. Rosenberg - Potomac MD, US

Assignee:

of Health and Human Services Office of Technology Transfer - Rockville MD

International Classification:

A61K 48/00
C12N 5/08

US Classification:

424 9321, 435455

Abstract:

Recombinant dendritic cells are made by transforming a stem cell and differentiating the stem cell into a dendritic cell. The resulting dendritic cell is an antigen presenting cell which activates T cells against MHC class I-antigen targets. Kits, assays and therapeutics are based upon the activation of T cells by the recombinant dendritic cell. Cancer, viral infections and parasitic infections are all ameliorated by the recombinant dendritic cells, or corresponding activated T cells. Therapeutic compositions and pharmaceutical compositions are provided.