Mark Charles Rosen

US Patent:

20220361774, Nov 17, 2022

Filed:

Jul 24, 2020

Appl. No.:

17/629412

Inventors:

- San Ramon CA, US
MARK ANDREW ROSEN - Piedmont CA, US
ADAM JACOBS - Hollis NH, US
RODNEY P. CHIN - Rodeo CA, US
DAVID BOAS - Boston MA, US
JANA M. KAINERSTORFER - Pittsburgh PA, US
RUSSELL DELONZOR - San Ramon CA, US
DENISE ZARINS - Saratoga CA, US

International Classification:

A61B 5/1464
A61B 5/1455
A61B 5/1495

Abstract:

Systems, devices, and methods for performing trans-abdominal fetal oximetry and/or trans-abdominal fetal pulse oximetry using physiological characteristics and/or a calibration factor may receive a physiological characteristic of a pregnant mammal and determine one or more potential impact(s) of the physiological characteristic on a behavior of an optical signal projected into the abdomen of the pregnant mammal Then a calibration factor for the optical signal responsively to the impact. The calibration factor may then be used to calibrate a fetal detected electronic signal so that a level of fetal hemoglobin oxygen saturation may be determined.

US Patent:

20220354390, Nov 10, 2022

Filed:

Jul 20, 2022

Appl. No.:

17/869251

Inventors:

- San Ramon CA, US
Mark Andrew ROSEN - Piedmont CA, US
Adam JACOBS - Hollis NH, US
Kenneth HOLT - Cacadero CA, US

International Classification:

A61B 5/1464
A61B 5/145
A61B 5/1455
A61B 5/00

Abstract:

Independent component analysis may be performed on a plurality of detected electronic signals to separate signals within the detected electronic signals that are contributed by different sources. Each of the plurality of detected electronic signals may be received from a separate detector and may correspond to a detected optical signal emanating from a pregnant mammal's abdomen and a fetus contained therein. The detected optical signals may correspond to light that is projected into the pregnant mammal's abdomen from a light source. The separated signals may be analyzed to determine a separated signal that corresponds to light incident upon the fetus, which may be analyzed to determine a fetal hemoglobin oxygen saturation level of the fetus. An indication of the fetal hemoglobin oxygen saturation level may then be provided to the user.

US Patent:

20220338739, Oct 27, 2022

Filed:

Sep 16, 2020

Appl. No.:

17/761069

Inventors:

- San Ramon CA, US
MARK ANDREW ROSEN - Piedmont CA, US
NEIL PADHARIA RAY - Sacramento CA, US

International Classification:

A61B 5/00
A61B 5/1455
A61B 8/08
A61B 8/02

Abstract:

Photoacoustic and/or acousto-optical techniques may be used to transabdominally perform fetal oximetry and/or trans-abdominal fetal pulse oximetry. In some cases, a composite acoustic signal that has emanated from an abdomen of a pregnant mammal may be received by a processor from, for example, an ultrasonic detector and/or microphone positioned on, or near, a pregnant mammal's abdomen and the composite acoustic signal may result from an optical signal incident on the pregnant mammal's abdomen and a fetus contained therein. A portion of the composite acoustic signal that was incident on the fetus may be isolated from the composite acoustic signal and then analyzed to determine a fetal hemoglobin oxygen saturation level and/or a fetal tissue oxygen saturation level.

US Patent:

20210251524, Aug 19, 2021

Filed:

Apr 23, 2021

Appl. No.:

17/239009

Inventors:

- San Ramon CA, US
Mark Andrew ROSEN - Piedmont CA, US
Adam JACOBS - Hollis NH, US
Denise ZARINS - Saratoga CA, US
Kenneth HOLT - Cacadero CA, US
Jana M. KAINERSTORFER - Pittsburg PA, US
David BOAS - Boston MA, US

International Classification:

A61B 5/1464
A61B 5/024
A61B 5/1455

Abstract:

Fetal tissue oxygenation may be performed transabdominally by, for example, receiving a plurality of detected electronic signals that correspond to light emitted from a pregnant mammal's abdomen and a fetus contained therein that has been detected by the detector and converted into the detected electronic signal. An indication of a depth of the fetus within the pregnant mammal's abdomen may be received and a portion of the detected electronic signals that correspond to light that was incident upon the fetus may be isolated responsively to the indication of the depth of the fetus using, for example, time of flight of photons that correspond to the detected electronic signals. A fetal tissue oxygen saturation level may then be determined using the isolated portion of the detected electronic signals that correspond to light that was incident upon the fetus.

US Patent:

20200359941, Nov 19, 2020

Filed:

Dec 28, 2018

Appl. No.:

16/958136

Inventors:

- San Ramon CA, US
Mark Andrew ROSEN - Piedmont CA, US
Adam JACOBS - Hollis NH, US
Kenneth HOLT - Cacadero CA, US

International Classification:

A61B 5/1464
A61B 5/1455
A61B 5/145
A61B 5/00

Abstract:

Independent component analysis may be performed on a plurality of detected electronic signals to separate signals within the detected electronic signals that are contributed by different sources. Each of the plurality of detected electronic signals may be received from a separate detector and may correspond to a detected optical signal emanating from a pregnant mammal's abdomen and a fetus contained therein. The detected optical signals may correspond to light that is projected into the pregnant mammal's abdomen from a light source. The separated signals may be analyzed to determine a separated signal that corresponds to light incident upon the fetus, which may be analyzed to determine a fetal hemoglobin oxygen saturation level of the fetus. An indication of the fetal hemoglobin oxygen saturation level may then be provided to the user.

US Patent:

20200352487, Nov 12, 2020

Filed:

Dec 28, 2018

Appl. No.:

16/958133

Inventors:

- San Ramon CA, US
Mark Andrew ROSEN - Piedmont CA, US
Adam JACOBS - Hollis NH, US
Nevan HANUMARA - Cambridge MA, US

Assignee:

Raydiant Oximetry, Inc. - San Ramon CA

International Classification:

A61B 5/1455
A61B 5/1464
A61B 5/00
A61B 5/107
A61B 5/055
A61B 8/08

Abstract:

A system and/or device for transabdominal fetal oximetry and/or fetal pulse oximetry and/or uterine tone determination may include one or more articulating, adjustable, and/or selectable components such as a light source and/or a photodetector. In some embodiments, the positioning of a light source and/or detector may be adjustable. The articulation and/or adjustment of position of the light source and/or photodetector may be in any plane (X, Y, and/or Z) and, in some instances, may be responsive to a fetal position within a maternal abdomen. Light detected by the detectors may be used to determine a fetal hemoglobin oxygen saturation level and/or a muscular state (e.g., contracted or relaxed) of the pregnant mammal's uterus.

US Patent:

20200323467, Oct 15, 2020

Filed:

Jun 25, 2020

Appl. No.:

16/912627

Inventors:

- San Ramon CA, US
Mark Andrew ROSEN - Piedmont CA, US
Adam JACOBS - Hollis NH, US
Denise ZARINS - Saratoga CA, US
Kenneth HOLT - Cacadero CA, US
Jana M KAINERSTORFER - Pittsburg PA, US
David BOAS - Boston MA, US

International Classification:

A61B 5/1464
A61B 5/024
A61B 5/1455

Abstract:

Fetal tissue oxygenation may be performed transabdominally by, for example, receiving a plurality of detected electronic signals that correspond to light emitted from a pregnant mammal's abdomen and a fetus contained therein that has been detected by the detector and converted into the detected electronic signal. An indication of a depth of the fetus within the pregnant mammal's abdomen may be received and a portion of the detected electronic signals that correspond to light that was incident upon the fetus may be isolated responsively to the indication of the depth of the fetus using, for example, time of flight of photons that correspond to the detected electronic signals. A fetal tissue oxygen saturation level may then be determined using the isolated portion of the detected electronic signals that correspond to light that was incident upon the fetus.