Mark V Spano

US Patent:

6606526, Aug 12, 2003

Filed:

Sep 26, 2001

Appl. No.:

09/962300

Inventors:

Mark L. Spano - Laurel MD
William L. Ditto - Woodstock GA
Visarath In - Atlanta GA

Assignee:

The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

G06F15500

US Classification:

700 91, 700 31, 700 32, 700 46, 700 90, 607 2, 607 5, 607 45, 607 46, 380263

Abstract:

An accessible parameter of a chaos embodying system of a physical or biological type is monitored by extraction of measurement data and recordation thereof on a return map as a dynamic representation of the system activity, from which the magnitude and timing of intervention is determined and applied to the system in order to sustain chaos behavior.

US Patent:

57979650, Aug 25, 1998

Filed:

Mar 26, 1997

Appl. No.:

8/825150

Inventors:

Mark L. Spano - Laurel MD
Steven J. Schiff - Rockville MD
Bruce J. Gluckman - Arlington VA
William L. Ditto - Woodstock GA

Assignee:

The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

A61N 118

US Classification:

607 2

Abstract:

A DC electric field is applied to brain tissue in parallel alignment with urons thereof during periods of brief duration while the tissue is undergoing epileptic activity. The electrical field is controllably varied in magnitude to suppress such epilieptic activity.

US Patent:

53424018, Aug 30, 1994

Filed:

Aug 19, 1992

Appl. No.:

7/930945

Inventors:

Mark L. Spano - Laurel MD
William L. Ditto - Wooster OH
Alan Garfinkel - Venice CA
James N. Weiss - Encino CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61N 100

US Classification:

607 5

Abstract:

Electrical stimuli delivered to cardiac tissue at times determined from a chaos stabilizing algorithm, converts arrhythmia activity to periodic beating by an interbeat interval shortening action, utilizing real time calculation based on a system parameter experimentally determined from intervention by the electrical stimuli.

US Patent:

55228631, Jun 4, 1996

Filed:

Aug 19, 1994

Appl. No.:

8/292999

Inventors:

Mark L. Spano - Laurel MD
William L. Ditto - Marietta GA
Steven J. Schiff - Rockville MD

Assignee:

The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

A61N 118

US Classification:

607 45

Abstract:

The pulsating behavioral activity of a neural network such as that embodied n a brain tissue slice is monitored by measurement of intervals between spontaneous events to identify the presence of a chaotic regime and determine by real-time calculation a waiting time for electrical pulse intervention pursuant to a behavioral modifying program having a control or anti-control strategy.

US Patent:

54475201, Sep 5, 1995

Filed:

Mar 29, 1994

Appl. No.:

8/219567

Inventors:

Mark L. Spano - Laurel MD
William L. Ditto - Wooster OH
Alan Garfinkel - Venice CA
James N. Weiss - Encino CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61N 139

US Classification:

607 5

Abstract:

Electrical stimuli delivered to cardiac tissue at times determined from a chaos stabilizing algorithm, converts arrhythmia activity to periodic beating by an interbeat interval shortening action, utilizing real time calculation based on a system parameter experimentally determined from intervention by the electrical stimuli.

US Patent:

58004599, Sep 1, 1998

Filed:

Dec 24, 1996

Appl. No.:

8/773459

Inventors:

Mark L. Spano - Laurel MD
Steven J. Schiff - Rockville MD
Bruce J. Gluckman - Arlington VA
William L. Ditto - Woodstock GA

Assignee:

The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

A66N 140

US Classification:

607 2

Abstract:

A DC electric field is applied to brain tissue in parallel alignment with urons thereof during periods of brief duration while the tissue is undergoing epileptic activity. The electric field is controllably changed in polarity and magnitude to modify such epileptic activity based on data obtained by recording such activity through electrodes that are isopotentially aligned within the electric field imposed on a slice of the brain tissue.