Mark O Stahl

US Patent:

54053170, Apr 11, 1995

Filed:

Oct 30, 1992

Appl. No.:

7/938033

Inventors:

Robert M. Myers - Menlo Park CA
Mark G. Stahl - Fremont CA
Felix A. Landrau - San Jose CA
J. Richard Gyory - San Jose CA

Assignee:

ALZA Corporation - Palo Alto CA

International Classification:

A61N 130

US Classification:

604 20

Abstract:

An electrically powered iontophoretic delivery device is provided. The device utilizes electrodes composed of a preferably hydrophobic polymeric matrix. The matrix contains about 10 to 50 vol % of a material capable of absorbing a liquid solvent, typically water, to provide a plurality of ion conducting pathways through the matrix. The matrix also contains about 5 to 40 vol % of a chemical species which is able to undergo either oxidation or reduction during operation of the device. Preferably, the solvent absorbing material is a hydrophilic polymer such as polyvinylpyrrolidone. For the anodic electrode, the chemical species should be able to undergo oxidation and is preferably either silver or zinc. For the cathodic electrode, the chemical species should be able to undergo reduction and is preferably silver chloride or a reducible metal.

US Patent:

51472970, Sep 15, 1992

Filed:

May 7, 1990

Appl. No.:

7/521761

Inventors:

Robert M. Myers - Stanford CA
Mark G. Stahl - Sunnyvale CA

Assignee:

Alza Corporation - Palo Alto CA

International Classification:

A61N 130

US Classification:

604 20

Abstract:

An electrically powered iontophoretic delivery device is provided. The device utilizes electrodes composed of a polymeric matrix containing about 5 to 40 vol % of a conductive filler which forms a conductive network through the matrix, and about 5 to 40 vol % of a chemical species which is able to undergo either oxidation or reduction during operation of the device. Preferably, the conductive filler is carbon or graphite fibers. For the anode electrode, the chemical species should be able to undergo oxidation and is preferably either silver or zinc. For the cathode electrode, the chemical species should be able to undergo reduction and is preferably silver chloride.

US Patent:

52643662, Nov 23, 1993

Filed:

Nov 25, 1991

Appl. No.:

7/797577

Inventors:

Eugenio Ferrari - San Bruno CA
Dennis J. Henner - Pacifica CA
Mark L. Stahl - Arlington MA

Assignee:

Genencor, Inc. - So. San Francisco CA

International Classification:

C12N 1500
C12N 1503
C12N 1531
C12N 1575

US Classification:

43525231

Abstract:

There are described, normally sporulating mutant Bacillus strain(s) which produce no detectable proteolytic activity during any phase of its growth. The absence of detectable proteolytic activity is due to the deletion of one or more codons specifying the mature subtilisin protease and the mature neutral protease. Also described are methods for producing such normally sporulating, protease deficient Bacillus mutants.