Martha A Hayden

US Patent:

6482919, Nov 19, 2002

Filed:

Mar 21, 2001

Appl. No.:

09/813659

Inventors:

Jeffrey A. Ledbetter - Seattle WA
Martha S. Hayden - Everett WA
Peter S. Linsley - Seattle WA
Jurgen Bajorath - Everett WA
H. Perry Fell - Redmond WA
Lisa K. Gilliland - Oxford, GB

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07K 1628

US Classification:

530324, 530350, 5303871, 5303873, 5303879, 530327, 530328, 530329, 530330

Abstract:

The present invention provides novel soluble CTLA4Ig molecules having modified Ig domains.

US Patent:

6699715, Mar 2, 2004

Filed:

Nov 27, 1996

Appl. No.:

08/756416

Inventors:

Jeffrey A. Ledbetter - Seattle WA
Martha Hayden - Everett WA
Perry Fell - Redmond WA
Robert Mittler - Woodinville WA
Gosta Winberg - Bromma, SE

Assignee:

Bristol-Myers Squibb Co. - Princeton NJ

International Classification:

A61K 39395

US Classification:

435328, 4241341, 4241351, 435 697, 5303873

Abstract:

The modified sFv molecules of the present invention stimulate adhesion between cells thereby enhancing the immune response against disease. These molecules generally comprise an antigen binding site of an antibody and at least a portion of a transmembrane domain of a cell surface receptor.

US Patent:

7915395, Mar 29, 2011

Filed:

Oct 29, 2002

Appl. No.:

10/283610

Inventors:

Jeffrey A. Ledbetter - Seattle WA, US
Martha S. Hayden - Everett WA, US
Peter S. Linsley - Seattle WA, US
Jurgen Bajorath - Lynnwood WA, US
H. Perry Fell - Redmond WA, US
Lisa K. Gilliland - Oxford, GB

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07H 21/04
C12P 21/06
C12P 21/04

US Classification:

536 234, 435 691, 435 696

Abstract:

The present invention provides an expression vector encoding monospecific or bispecific fusion protein. In one embodiment the expression vector encodes a monospecific fusion protein, which vector comprises a recombinant monospecific single chain cassette comprising a DNA sequence encoding a first binding domain capable of binding a cell surface antigen. In another embodiment the expression vector encodes a bispecific fusion protein, which vector comprises a recombinant bispecific single chain cassette comprising a DNA sequence encoding a first binding domain capable of binding a cell surface antigen and a DNA sequence encoding a second binding domain capable of binding a cell surface antigen, each domain capable of binding a different antigen. The present invention also provides a method for producing a biologically active monospecific or bispecific fusion protein in a mammalian cell.

US Patent:

61329924, Oct 17, 2000

Filed:

Oct 5, 1995

Appl. No.:

8/539436

Inventors:

Jeffrey A. Ledbetter - Seattle WA
Lisa K. Gilliland - Seattle WA
Martha S. Hayden - San Diego CA
Peter S. Linsley - Seattle WA
Jurgen Bajorath - Everett WA
H. Perry Fell - Redmond WA

Assignee:

Bristol-Myers Squibb Co. - New York NY

International Classification:

C12P 2102
C12N 1585
C07K 1628

US Classification:

435 697

Abstract:

The present invention provides an expression vector encoding monospecific or bispecific fusion protein. In one embodiment the expression vector encodes a monospecific fusion protein, which vector comprises a recombinant monospecific single chain cassette comprising a DNA sequence encoding a first binding domain capable of binding a cell surface antigen. In another embodiment the expression vector encodes a bispecific fusion protein, which vector comprises a recombinant bispecific single chain cassette comprising a DNA sequence encoding a first binding domain capable of binding a cell surface antigen and a DNA sequence encoding a second binding domain capable of binding a cell surface antigen, each domain capable of binding a different antigen. The present invention also provides a method for producing a biologically active monospecific or bispecific fusion protein in a mammalian cell. This method comprises: (a) transfecting the mammalian cell with the recombinant expression vector of the invention; (b) culturing the mammalian cell so transfected in step (a); and (c) recovering the biologically active bispecific fusion protein so as produced by the cultured mammalian cell.

US Patent:

56374810, Jun 10, 1997

Filed:

Sep 13, 1993

Appl. No.:

8/121054

Inventors:

Jeffrey A. Ledbetter - Seattle WA
Lisa K. Gilliland - Seattle WA
Martha S. Hayden - San Diego CA
Peter S. Linsley - Seattle WA
Jurgen Bajorath - Everett WA
H. Perry Fell - Redmond WA

Assignee:

Bristol-Myers Squibb Company - New York NY

International Classification:

C12N 1579
C12N 510
C12P 2100

US Classification:

435 696

Abstract:

The present invention provides an expression vector encoding monospecific or bispecific fusion protein. In one embodiment the expression vector encodes a monospecific fusion protein, which vector comprises a recombinant monospecific single chain cassette comprising a DNA sequence encoding a first binding domain capable of binding a cell surface antigen.

US Patent:

53386787, Aug 16, 1994

Filed:

Jun 1, 1990

Appl. No.:

7/531646

Inventors:

Peter D. Senter - Seattle WA
Peter C. D. Su - Mercer Island WA
Hans Marquardt - Mercer Island WA
Martha S. Hayden - Seattle WA
Peter Linsley - Seattle WA

Assignee:

Oncogen, a Limited Partnership - Seattle WA

International Classification:

C12N 500
C12N 120
C12N 1500
C07H 1512

US Classification:

435227

Abstract:

Thermally stable cytosine deaminase (CDase), and the gene coding therefor, is disclosed as well as methods of isolating, purifying, and recombinantly producing the same. The thermally stable CDase can be isolated from Saccharomyces cerevisiae. The yeast isolated enzyme has a molecular weight of approximately 32 kDa, as determined by gel filtration chromatography, and is composed of two subunits, each with a molecular weight of about 17 kDa. Thermally stable yeast CDase so purified shows no significant sequence homology with other known sequenced proteins.

US Patent:

55455484, Aug 13, 1996

Filed:

Jun 20, 1994

Appl. No.:

8/262238

Inventors:

Peter D. Senter - Seattle WA
Peter C. Su - Mercer Island WA
Hans Marquardt - Mercer Island WA
Martha S. Hayden - Seattle WA
Peter Linsley - Seattle WA

Assignee:

Oncogen - Seattle WA

International Classification:

C12N 978

US Classification:

435227

Abstract:

Thermally stable cytosine deaminase (CDase), and the gene coding therefor, is disclosed as well as methods of isolating, purifying, and recombinantly producing the same. The thermally stable CDase can be isolated from Saccharomyces cerevisiae. The yeast isolated enzyme has a molecular weight of approximately 32 kDa, as determined by gel filtration chromatography, and is composed of two subunits, each with a molecular weight of about 17 kDa. Thermally stable yeast CDase so purified shows no significant sequence homology with other known sequenced proteins.