Martha W Knight

US Patent:

8597509, Dec 3, 2013

Filed:

Nov 18, 2009

Appl. No.:

13/129811

Inventors:

Martha Knight - Washington DC, US
Thomas M Finn - Rockville ND, US

Assignee:

CC Biotech LLC - Rockville MD

International Classification:

B01D 15/08

US Classification:

2101982, 210635, 210656, 210657

Abstract:

The present invention describes a method for constructing a spiral tube support apparatus used in countercurrent chromatography, improvements to countercurrent chromatography tube support design, and methods of using the improved countercurrent chromatography apparatus. The spiral tube support apparatus may be constructed by a shape forming process such as a three dimensional printing process that in turn uses a laser sintering technique, and can be made out of any easily formed material. Shape changes on both the tube support and the top improve the performance of the tube support and ease of manufacturing. The improved tube support and new method of creation permit use in both micro or macro scale preparations and use in small or large molecule preparations. In particular, specific solvent systems are described that permit purification of proteins.

US Patent:

51698625, Dec 8, 1992

Filed:

Nov 18, 1991

Appl. No.:

7/793153

Inventors:

Terrence Burke - Bethesda MD
Bhaskar Chandrasekhar - Silver Spring MD
Martha Knight - Bethesda MD

Assignee:

Peptide Technologies Corporation - Washington DC

International Classification:

A61K 31335
C07D32300

US Classification:

514450

Abstract:

This invention is directed to the analogs of viscosin, pharmaceutical compositions thereof and to their use as antibacterial, antiviral and antitrypanosomal therapeutic compounds.

US Patent:

56209550, Apr 15, 1997

Filed:

Dec 17, 1993

Appl. No.:

8/168390

Inventors:

Martha Knight - Washington DC
Kazuyuki Takahashi - Germantown MD
Bhaskar Chandrasekhar - Potomac MD

Assignee:

Peptide Technologies Corporation - Gaithersburg MD

International Classification:

A61K 3800
C07K 708

US Classification:

514 14

Abstract:

Bombesin is an amphibian peptide that has a structure closely related to that of several mammalian peptides, including Gastrin Releasing Peptide (GRP) and Neuromedins B and C. Bombesin, GRP and related peptides exert their in vivo effects by binding to specific receptors present on cells of the gastrointestinal tract, the central nervous system, and tumors. The invention relates to novel bombesin derivatives which act as bombesin receptor antagonists by blocking the binding of bombesin, GRP or related peptides to cellular receptors. By blocking the binding of bombesin, GRP and related peptides to cellular receptors on cancer cells, these antagonists inhibit the growth of tumor cells that respond to the growth-promoting action of bombesin. These antagonists are expected to block the binding of bombesin, GRP or related peptides to similar receptors on cells in the gastrointestinal tract or the central nervous system. Thus, these antagonists have therapeutic use in the treatment or prevention of conditions mediated by bombesin, GRP or related peptides, including cancer and gastrointestinal disorders such as peptic ulcer, pancreatitis, and feeding disorders.

US Patent:

59655240, Oct 12, 1999

Filed:

Sep 6, 1994

Appl. No.:

8/341710

Inventors:

Terrance Burke - Bethesda MD
Bhaskar Chandrasekhar - Potomac MD
Martha Knight - Washington DC

Assignee:

Peptide Technologies Corporation - Gaithersburg MD

International Classification:

A61K 3800

US Classification:

514 9

Abstract:

This invention is directed to the analogs of viscosin, pharmaceutical compositions thereof and to methods of using viscosin and analogs thereof as biosurfactants and as antibacterial, antiviral and antitrypanosomal therapeutic compounds. In particular, compositions that inhibit the growth of the pathogens Mycobacterium tuberculosis, Herpes Simplex Virus 2 and/or Trypanosoma cruzi are disclosed.

US Patent:

20210079361, Mar 18, 2021

Filed:

Nov 29, 2020

Appl. No.:

17/106135

Inventors:

- Rockville MD, US
Martha Knight - Washington DC, US

International Classification:

C12N 7/00
B01D 15/18
B01D 15/42

Abstract:

A spiral tube countercurrent chromatography rotor for separating virus in a two part aqueous solvent is described.