Martha A O'Brien from Madison, WI, age 68

Martha O'brien

License #:

LAC-011-2994 - Expired

Category:

Asbestos Program

Issued Date:

Aug 11, 1990

Expiration Date:

Jul 31, 2002

Type:

Asbestos Supervisor

Architect

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Industry:

Architecture & Planning

Work:

Obrecht Commercial Real Estate
Architect

Statistical Programmer And Analyst

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Location:

121 east Haven Dr, Watertown, WI 53094

Industry:

Pharmaceuticals

Work:

Chiltern
Statistical Programmer and Analyst
Covance
Supervisor
Covance Oct 2012 - Sep 2014
Sas Programmer I - Datasets
Covance Oct 2012 - Sep 2014
Sas Programmer Ii-Datasets
Covance Feb 2011 - Oct 2012
Samples Coordinator Iii

Education:

University of Wisconsin - Madison 2008 - 2010
Master of Science, Masters University of Wisconsin - River Falls 2005 - 2008
Bachelors, Bachelor of Science, Mathematics, Biochemistry

Skills:

Sas Programming
Public Speaking
Microsoft Excel
Microsoft Office
Microsoft Word
Customer Service
Powerpoint
English
Research
Windows
Outlook
Photoshop
Teaching
Html
Budgets
Strategic Planning
R

Martha A (G O'brien O'brien

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Martha O'brien

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Martha E O'brien

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Skills:

Microsoft Office

Martha O'brien

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Location:

United States

Martha O'Brien - Lawyer

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Specialties:

Tax

ISLN:

904748916

Admitted:

1986

University:

Free University of Brussels, Belgium, 1992; University of Victoria, B.A., 1980

Law School:

University of Victoria, LL.B., 1984

Us Patents

Bioluminescent Protease Assay With Modified Aminoluciferin Or Derivatives Thereof
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US Patent:

7384758, Jun 10, 2008
Filed:

Feb 2, 2006
Appl. No.:

11/346043
Inventors:

Martha O'Brien - Madison WI, US
Keith V. Wood - Mt. Horeb WI, US
Dieter Klaubert - Arroyo Grande CA, US
William Daily - Santa Maria CA, US
Assignee:

Promeaga Corporation - Madison WI
International Classification:

C12Q 1/66
US Classification:

435 8, 435 23, 435 24
Abstract:

A sensitive bioluminescent assay to detect proteases, including caspases and proteases that specifically cleave a peptide substrate having aspartate, is provided. In one embodiment, the assay employs an aminoluciferin or a carboxy-terminal protected derivative thereof covalently linked via a peptide bond to a substrate for a caspase or an aminoluciferin or a carboxy-terminal protected derivative thereof covalently linked via a peptide bond to a peptide substrate comprising aspartate that is specifically cleaved by a protease specific for the substrate.

Bioluminescent Caspase Assay Compounds
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US Patent:

7666987, Feb 23, 2010
Filed:

Feb 3, 2006
Appl. No.:

11/347054
Inventors:

Martha O'Brien - Madison WI, US
Keith V. Wood - Mt. Horeb WI, US
Dieter Klaubert - Arroyo Grande CA, US
William Daily - Santa Maria CA, US
Assignee:

Promega Corporation - Madison WI
International Classification:

C07K 1/00
US Classification:

530335, 435 8
Abstract:

A sensitive bioluminescent assay to detect proteases including caspases is provided which employs an aminoluciferin or a carboxy-terminal protected derivative thereof covalently linked via a peptide bond to a substrate for a caspase or an aminoluciferin or a carboxy-terminal protected derivative thereof covalently linked via a peptide bond to a peptide substrate comprising aspartate that is specifically cleaved by a protease specific for the substrate.

Bioluminescent Protease Assay
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US Patent:

8071328, Dec 6, 2011
Filed:

Feb 16, 2010
Appl. No.:

12/706078
Inventors:

Martha O'Brien - Madison WI, US
Keith V. Wood - Mt. Horeb WI, US
Dieter Klaubert - Arroyo Grande CA, US
William Daily - Santa Maria CA, US
Assignee:

Promega Corporation - Madison WI
International Classification:

C12Q 1/37
US Classification:

435 23, 435 8, 530335
Abstract:

A sensitive bioluminescent assay to detect proteases including caspases, trypsin and tryptase is provided.

Luciferase-Based Assays
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US Patent:

8361739, Jan 29, 2013
Filed:

Jun 21, 2010
Appl. No.:

12/819334
Inventors:

Erika Hawkins - Madison WI, US
James J. Cali - Verona WI, US
Samuel Kin Sang Ho - New Bedford MA, US
Martha A. O'Brien - Madison WI, US
Richard Somberg - Madison WI, US
Robert F. Bulleit - Verona WI, US
Keith V. Wood - Mount Horeb WI, US
Assignee:

Promega Corporation - Madison WI
International Classification:

C12Q 1/66
C12Q 1/34
C12Q 1/37
US Classification:

435 8, 435 18, 435 23
Abstract:

A method and kit are provided for enhancing the tolerance of an assay reagent to compounds in an assay sample, the assay reagent including a luciferase enzyme. The method includes contacting the luciferase with a tolerance enhancement agent in an amount sufficient to substantially protect luciferase enzyme activity from interference of the compound and minimize interference by at least about 10% relative to an assay not having tolerance enhancement agent.

Luciferase-Based Assays
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US Patent:

8603767, Dec 10, 2013
Filed:

Jan 25, 2013
Appl. No.:

13/750284
Inventors:

James J. Cali - Verona WI, US
Samuel Kin Sang Ho - New Bedford MA, US
Martha A. O'Brien - Madison WI, US
Richard Somberg - Madison WI, US
Robert F. Bulleit - Verona WI, US
Keith V. Wood - Mount Horeb WI, US
Assignee:

Promega Corporation - Madison WI
International Classification:

C12Q 1/66
C12Q 1/34
C12Q 1/37
US Classification:

435 8, 435 18, 435 23
Abstract:

A method and kit are provided for enhancing the tolerance of an assay reagent to compounds in an assay sample, the assay reagent including a luciferase enzyme. The method includes contacting the luciferase with a tolerance enhancement agent in an amount sufficient to substantially protect luciferase enzyme activity from interference of the compound and minimize interference by at least about 10% relative to an assay not having tolerance enhancement agent.

Bioluminescent Protease Assay
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US Patent:

20030211560, Nov 13, 2003
Filed:

Jan 31, 2003
Appl. No.:

10/356665
Inventors:

Martha O'Brien - Madison WI, US
Keith Wood - Mt. Horeb WI, US
Dieter Klaubert - Arroyo Grande CA, US
William Daily - Santa Maria CA, US
International Classification:

C12Q001/66
US Classification:

435/008000
Abstract:

A sensitive bioluminescent assay to detect proteases including caspases, trypsin and tryptase is provided.

Luciferase-Based Assays
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US Patent:

20050026171, Feb 3, 2005
Filed:

Dec 23, 2003
Appl. No.:

10/746995
Inventors:

Erika Hawkins - Madison WI, US
James Cali - Verona WI, US
Samuel Ho - New Bedford MA, US
Martha O'Brien - Madison WI, US
Richard Somberg - Madison WI, US
Robert Bulleit - Verona WI, US
Keith Wood - Mount Horeb WI, US
International Classification:

C12Q001/68
C12Q001/66
US Classification:

435006000, 435008000
Abstract:

A method and kit is provided for enhancing the tolerance of an assay reagent to compounds in an assay sample, the assay reagent including a luciferase enzyme. The method includes contacting the luciferase with a tolerance enhancement agent in an amount sufficient to substantially protect luciferase enzyme activity from interference of the compound and minize interference by at least about 10% relative to an assay not having tolerance enhancement agent.

Methods For Assaying Enzyme Activities
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US Patent:

20120064554, Mar 15, 2012
Filed:

Sep 9, 2011
Appl. No.:

13/228791
Inventors:

Thomas Kirkland - Atascadero CA, US
Andrew L. Niles - Madison WI, US
Martha O'Brien - Madison WI, US
Carolyn Woodroofe Hitko - Grover Beach CA, US
Assignee:

PROMEGA CORPORATION - Madison WI
International Classification:

C12Q 1/37
C12Q 1/48
C07K 5/103
C07K 2/00
C07K 7/06
US Classification:

435 15, 530300, 530330, 530329, 530328, 435 23
Abstract:

The present invention provides compounds and methods for assaying activities of enzymes such as histone deacetylases and histone acetyltransferases. In some embodiments, the methods may be performed in one step. The compounds described herein features peptide-based compounds having at least one blocked lysine or arginine residue which are coupled to reporter moieties. The methods described herein involve reacting a compound described herein with an enzyme, such as a histone deacetylase enzyme or a histone acetyltransferase enzyme, and an endopeptidase that recognizes basic amino acids to release the reporter moiety which may be subsequently detected.