Martin M Bryant

US Patent:

6515028, Feb 4, 2003

Filed:

Feb 14, 2000

Appl. No.:

09/503865

Inventors:

Richard A. Mueller - Glencoe IL
Martin L. Bryant - Carlisle MA
Richard A. Partis - Evanston IL

Assignee:

G.D. Searle Co. - Chicago IL

International Classification:

A61K 31165

US Classification:

514617, 514618, 564161, 564192

Abstract:

N-Substituted glucamine compounds of Formula I are effective in treatment of hepatitis infections, including hepatitis B and hepatitis C. In treating hepatitis infections, the compounds of Formula I may be used alone, or in combination with another antiviral agents selected from among nucleosides, nucleotides, immunomodulators, immunostimulants or various combinations of such other agents.

US Patent:

6545021, Apr 8, 2003

Filed:

Feb 14, 2000

Appl. No.:

09/503945

Inventors:

Richard A. Mueller - Glencoe IL
Martin L. Bryant - Los Altos CA
Richard A. Partis - Evanston IL

Assignee:

G.D. Searle Co. - Skokie IL

International Classification:

A61K 31445

US Classification:

514318, 5142355, 514302, 514315, 514316, 514319, 514326, 514328, 514885, 546115, 546116, 546193, 546205, 546207, 544129

Abstract:

N-Substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds of Formula I are effective in treatment of hepatitis infections, including hepatitis B and hepatitis C. In treating hepatitis infections, the compounds of Formula I may be used alone, or in combination with another antiviral agent selected from among nucleosides, nucleotides, immunomodulators, immunostimulats or various combinations of such other agents.

US Patent:

6809083, Oct 26, 2004

Filed:

Feb 12, 1999

Appl. No.:

09/249220

Inventors:

Richard A. Mueller - Glencoe IL 60022
Martin L. Bryant - Los Altos CA 94024
Richard A. Partis - Evanston IL 63141
Gary S. Jacob - Creve Coeur MO 63141
Timothy M. Block - Jenkintown PA 19046
Raymond A. Dwek - Oxford OX1 3QU, GB

International Classification:

A01N 4304

US Classification:

514 45, 514 1, 514 42, 514 43, 514 89, 514277, 514315, 435 5

Abstract:

Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immuno-stimulating agents.

US Patent:

20030220299, Nov 27, 2003

Filed:

Jan 14, 2003

Appl. No.:

10/341717

Inventors:

Richard Mueller - Glencoe IL, US
Martin Bryant - Carlisle MA, US
Richard Partis - Evanston IL, US

Assignee:

G.D. Searle & Co.

International Classification:

A61K031/675
A61K031/445

US Classification:

514/089000, 514/328000

Abstract:

N-Substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds of Formula I are effective in treatment of hepatitis infections, including hepatitis B and hepatitis C. In treating hepatitis infections, the compounds of Formula I may be used alone, or in combination with another antiviral agent selected from among nucleosides, nucleotides, immunomodulators, immunostimulants or various combinations of such other agents.

US Patent:

20050119310, Jun 2, 2005

Filed:

Feb 13, 2001

Appl. No.:

10/203769

Inventors:

Richard Mueller - Glencoe IL, US
Martin Bryant - Carlisle MA, US
Kimberly Bryant - Carlisle MA, US

International Classification:

A61K031/445

US Classification:

514328000, 514326000

Abstract:

Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immuno-stimulating agents.

US Patent:

20050267153, Dec 1, 2005

Filed:

Aug 3, 2004

Appl. No.:

10/910197

Inventors:

Richard Mueller - Glencoe IL, US
Martin Bryant - Carlisle MA, US
Richard Partis - Evanston IL, US
Gary Jacob - Creve Coeur MO, US
Timothy Block - Jenkintown PA, US
Raymond Dwek - Oxford, GB

International Classification:

A61K031/445

US Classification:

514328000, 514317000

Abstract:

Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immuno-stimulating agents.