Martin E Sanders

US Patent:

8288438, Oct 16, 2012

Filed:

Mar 21, 2006

Appl. No.:

11/908952

Inventors:

Martin E. Sanders - Hillsborough CA, US
David B. Karpf - Monte Sereno CA, US

Assignee:

Metabolex, Inc. - Hayward CA
Dia Tex, Inc. - San Antonio TX

International Classification:

A61K 31/20

US Classification:

514559

Abstract:

Compounds, compositions, and methods of avoiding edema while treating or preventing PPARγ-mediated diseases, including cancer, using derivatives and prodrugs are provided.

US Patent:

8377435, Feb 19, 2013

Filed:

Nov 4, 2005

Appl. No.:

11/267935

Inventors:

Neelima M. Bhat - Los Altos CA, US
Marcia M. Bieber - Los Altos CA, US
Nelson N. H. Teng - Hillsborough CA, US
Martin E. Sanders - Hillsborough CA, US

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

International Classification:

A61K 39/395
A61K 39/00
C07K 16/00
C12P 21/08

US Classification:

4241301, 4241411, 4241421, 4241531, 4241551, 5303871, 5303881, 5303887, 53038873, 5303888

Abstract:

Compositions and methods for inducing cell membrane wounding, cell permeabilization and cell killing are provided. The composition comprises a polyvalent agent that binds to a highly expressed cell surface antigen present on the surface of a cell. Preferably, the cell surface antigen is associated with the cytoskeleton of the cell. A preferred polyvalent agent is an IgM, and enhanced cell wounding and killing can be provided by the addition of a crosslinking agent. At sublethal concentrations in vivo, the cell wounding antibodies permeabilize cells and dramatically enhance response to chemotherapeutic agents, even in patients refractory to the chemotherapeutic agents.

US Patent:

20050112130, May 26, 2005

Filed:

Nov 5, 2004

Appl. No.:

10/982698

Inventors:

Neelima Bhat - Los Altos CA, US
Marcia Bieber - Los Altos CA, US
Nelson Teng - Hillsborough CA, US
Martin Sanders - Hillsborough CA, US

International Classification:

A61K039/395
A61K039/42

US Classification:

424155100, 424159100, 514002000

Abstract:

Formulations and methods of treating human patients suffering from a condition characterized by lymphoid cancer, autoimmune disease or B cell hyperproliferation are disclosed, the treatment comprising administering (1) a cytotoxic amount of an antibody having specific binding for CDIM epitopes on a B cell, and (2) a cytotoxic agent, including a chemotherapeutic agent, radioactive isotope, cytotoxic antibody, immunoconjugate, ligand conjugate, immunosuppressant, cell growth regulator and/or inhibitor, toxin, or mixtures thereof, including agents that disrupt the cytoskeleton of B cells, particularly vinca alkaloids or colchicine.

US Patent:

20060240007, Oct 26, 2006

Filed:

Apr 20, 2006

Appl. No.:

11/407726

Inventors:

Martin Sanders - Hillsborough CA, US

International Classification:

A61K 39/395
A61K 31/55
A61K 31/445

US Classification:

424144100, 514214010, 514319000

Abstract:

Methods for treating Alzheimer's disease (AD) or dementia using a CD20 antibody are described. Articles of manufacture for use in such methods are also described.

US Patent:

20070081989, Apr 12, 2007

Filed:

Sep 19, 2006

Appl. No.:

11/524531

Inventors:

Martin Sanders - Hillsborough CA, US

International Classification:

A61K 39/395
G01N 33/567
A61K 39/00

US Classification:

424131100, 435007200, 424140100

Abstract:

Methods for reducing the number of pathologic antibody producing B cells in a patient suffering from an autoimmune disease by administration of an anti-germline antibody are described. Methods for removing pathologic antibodies and B cells and plasma cells producing pathologic antibodies from the body of a patient suffering from autoimmune disease are provided, comprising contacting the blood or plasma of the patient with an immunoadsorbent having specific binding for an epitope present on germline antibodies, particularly VH4-34 antibodies, wherein said contacting results in the reduction in the amount of germline antibodies present in the blood or bone marrow or lymphoid tissue of the patient or the amount of germline antibody producing B cells present in the blood, lymphoid tissues or bone marrow of the patient. Methods for treating a patient suffering from a B cell cancer expressing cell surface germline antibodies by similar methods are also provided. Methods for ex vivo purging bone marrow of pathologic antibody producing B-cells and cancerous B-cells expressing germline antibodies are provided. Methods for monitoring the efficacy of a therapeutic treatment in a patient suffering from an autoimmune disease or B cell cancer are also provided. Kits and uses in preparation of a medicament are also described.

US Patent:

20080031874, Feb 7, 2008

Filed:

Feb 6, 2007

Appl. No.:

11/703538

Inventors:

Martin Sanders - Hillsborough CA, US

International Classification:

A61K 39/40
A61K 39/00
A61P 43/00
C12Q 1/00

US Classification:

424133100, 424150100, 424164100, 435004000

Abstract:

Methods and compositions for selecting a patient suffering from endotoxemia for treatment with an endotoxin neutralizing agent are disclosed comprising: (a) determining the level of endotoxin in the patient's blood; and (b) comparing the endotoxin level in the patient's blood to a predetermined threshold endotoxin level to determine if the patient has elevated endotoxin levels. The methods can further comprise treating patients identified as having elevated levels of endotoxin with an endotoxin neutralizing therapy. The methods provide increased safety and a reduction in risk for critically ill patients.

US Patent:

20080194646, Aug 14, 2008

Filed:

Mar 21, 2006

Appl. No.:

11/908954

Inventors:

Martin E. Sanders - Hillsborough CA, US
David B. Karpf - Monte Sereno CA, US

International Classification:

A61K 31/44
A61K 31/216
A61K 31/4192
A61P 3/04
A61P 3/10
A61P 9/00
A61K 31/192

US Classification:

514354, 514533, 514571, 514359

Abstract:

Compounds, compositions, and methods of treating or preventing PPARγ-mediated diseases, including cancer, using phenoxy acetic acid derivatives and prodrugs are provided.

US Patent:

20090226439, Sep 10, 2009

Filed:

Apr 17, 2009

Appl. No.:

12/425537

Inventors:

Martin E. Sanders - Hillsborough CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

A61K 39/395
A61P 25/28

US Classification:

4241331, 4241721

Abstract:

Methods for treating Alzheimer's disease (AD) or dementia using a CD20 antibody are described. Articles of manufacture for use in such methods are also described.