Julian Adams - Boston MA, US Alfredo C. Castro - Winchester MA, US Michael A. Foley - Chestnut Hill MA, US Somarajan Nair Janardanan Nair - Belmont MA, US Marta Nevalainen - Quincy MA, US James R. Porter - Brighton MA, US Martin R. Tremblay - Melrose MA, US
Assignee:
Infinity Discovery, Inc. - Cambridge MA
International Classification:
A61K 31/438 A61K 31/4355 C07D 491/10 C07D 491/048
US Classification:
514278, 546 18, 546 15
Abstract:
The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.
Julian Adams - Boston MA, US Alfredo C. Castro - Winchester MA, US Michael A. Foley - Chestnut Hill MA, US Somarajan Nair Janardanan Nair - Belmont MA, US Marta Nevalainen - Quincy MA, US James R. Porter - Brighton MA, US Martin R. Tremblay - Melrose MA, US
Assignee:
Infinity Pharmaceuticals, Inc. - Cambridge MA
International Classification:
A61K 31/4355 C07D 491/048
US Classification:
514302, 546115, 546 15, 514278
Abstract:
The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.
Heterocyclic Cyclopamine Analogs And Methods Of Use Thereof
Brian Austad - Tewksbury MA, US Mark L. Behnke - Somerville MA, US Alfredo C. Castro - Winchester MA, US Michael J. Grogan - Winchester MA, US Andre Lescarbeau - Somerville MA, US Stephane Peluso - Somerville MA, US Martin Tremblay - Melrose MA, US
Assignee:
Infinity Pharmaceuticals, Inc. - Cambridge MA
International Classification:
C07D 401/00 C07D 515/02
US Classification:
546 17, 546115, 549331, 549345
Abstract:
The invention provides novel derivatives of cyclopamine having the following formula:.
Julian Adams - Boston MA, US Alfredo C. Castro - Winchester MA, US Michael A. Foley - Chestnut Hill MA, US Marta Nevalainen - Quincy MA, US James R. Porter - Rowley MA, US Martin R. Tremblay - Melrose MA, US
Assignee:
Infinity Discovery, Inc. - Cambridge MA
International Classification:
A61K 31/4355 C12N 9/99
US Classification:
514302, 514278, 435184
Abstract:
The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.
Cyclopamine Lactam Analogs And Methods Of Use Thereof
Alfredo C. Castro - Winchester MA, US Michael J. Grogan - Winchester MA, US William Matsui - Baltimore MD, US Karen J. McGovern - Groton MA, US Martin R. Tremblay - Melrose MA, US
Assignee:
Infinity Pharmaceuticals, Inc. - Cambridge MA
International Classification:
A61K 315/35 A61K 31/27 A61K 31/54 A61K 31/56
US Classification:
514455, 514 47, 514169, 514278
Abstract:
The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:.
Infinity Pharmaceuticals - Cambridge, MA since Mar 2012
Director
Infinity Pharmaceuticals - Cambridge, MA Jul 2008 - Feb 2012
Associate Director, Chemistry
Infinity Pharmaceuticals - Cambridge, MA Oct 2006 - Jun 2008
Lead Sr. Scientist
Infinity Pharmaceuticals - Cambridge, MA May 2004 - Sep 2006
Sr. Scientist
Eisai - Andover, MA May 2003 - Apr 2004
Sr. Research Investigator
Education:
The Scripps Research Institute 1999 - 2001
Postdoctoral, Chemistry
Université Laval 1993 - 1999
Doctorate, Medicinal chemistry
Jean Bernard, Daniel Brousseau, Harold Lavoie, Francois Villeneuve, Nicolas Cloutier, Karen Montreuil, Sylvain Dorion, Frederic Thibault, Frederic Leclerc, Bourget Alain
ards brother, ric, managing partner for the Montreal law firm Fasken Martineau, is a close associate of Mr. Pladeau. Another brother, Maxime, is vice-president of legal affairs for Quebecors Groupe TVA. Martin Tremblay, a former aide to Stphane Bdard, is also a Quebecor vice-president.
Martin Tremblay, 48, swept out the leg of an opposing player while the teams were going through the typical hockey ritual of lining up to shake hands after the game. Two players, a 10-year-old and a 13-year-old, fell to the ice. The move was caught on video and worked its way around the Internet.
Mounties are investigating allegations that a youth hockey coach tripped a player as opposing teams were shaking hands after a recent tournament game in Vancouver. UBC Hornets coach Martin Tremblay claims it was an accident, but he was arrested and assault charges are pending. One of the players inj
Date: Jun 30, 2012
Category: Health
Source: Google
VIDEO GAMES: 4.6 Million Copies of Batman; Arkham City Sold Since Its Oct ...
"Batman: Arkham City is one of the best action adventure games, proven by the tremendous reviews, and it further establishes the Batman brand as a marquee franchise for our growing business," said Martin Tremblay, President, Warner Bros. Interactive Entertainment. "Rocksteady Studios went above and
Date: Oct 25, 2011
Category: Entertainment
Source: Google
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Martin Tremblay
Work:
Les Affranchis - Directeur Technique (2009) LVL Studio - Programmeur principal (2004-2009)
Martin Tremblay
Work:
Moog Inc - Embedded Software Engineer
Martin Tremblay (Marty)
Martin Tremblay
Martin Tremblay
Martin Tremblay
Martin Tremblay
Martin Tremblay
Relationship:
In_a_relationship
Youtube
GUITARS RESTORATIONS SOUND SERIES *Martin Tre...
Guitar restoration Paris Musical petite bouche More info : tremblaylut...
Duration:
40s
Montreal Guitar Show '10 - Martin Tremblay Gu...
PG is On Location at the 2010 Montreal Guitar Show where we get to che...
Duration:
3m 56s
Martin Tremblay Charged with Seven New Offences
Today, Vancouver Police announced that Martin Tremblay has been arrest...
Duration:
7m 10s
satand by Martin tremblay (2005)
OUCH... from Jonquiere, former member f the Exo team Martin have an un...
Duration:
1m 27s
MARTIN TREMBLAY - Salon de guitare de Montral...
Retrouvez toutes les vidos sur .
Duration:
3m 1s
Hurt (Johnny Cash/Nine Inch Nails) Acoustic c...
Hurt (Johnny Cash/Nine Inch Nails) Acoustic cover par Martin Tremblay.