Martin Trudeau

US Patent:

6608087, Aug 19, 2003

Filed:

Jul 18, 2002

Appl. No.:

10/198407

Inventors:

Paul Charifson - Framingham MA
Dean Stamos - Framingham MA
Michael Badia - Bedford MA
Anne-Laure Grillot - Cambridge MA
Steven Ronkin - Watertown MA
Martin Trudeau - Tewksbury MA

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

C07D21302

US Classification:

514318, 546193, 546194

Abstract:

The present invention relates to compounds of the formula I: where Ring A is a thiazole, oxazole, imidazole or pyrazole and the substituents are as described in the specification, and pharmaceutically acceptable salts thereof. The compounds inhibit bacterial gyrase activity and therefore are useful for treating bacterial infections in mammals.

US Patent:

6632809, Oct 14, 2003

Filed:

Dec 12, 2001

Appl. No.:

10/015332

Inventors:

Anne-Laure Grillot - Cambridge MA
Paul Charifson - Framingham MA
Dean Stamos - Framingham MA
Yusheng Liao - Lexington MA
Michael Badia - Bedford MA
Martin Trudeau - Tewksbury MA

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

C07D40304

US Classification:

514215, 5142345, 51425214, 51425219, 514256, 514269, 514275, 514293, 514303, 514314, 514318, 514322, 514338, 514364, 514375, 514395, 548143, 548222, 5483047, 5483051, 5483061, 5483081, 546 82, 546118, 546167, 546193, 546199, 5462717, 5462731, 5462734, 544122, 544124, 544324, 544330, 544331, 544333, 540578

Abstract:

The present invention relates to compounds of the formula I: or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also relates to methods for treating bacterial infections in mammala. The present invention also relates to methods for decreasing bacterial quantity in a biological sample.

US Patent:

6930116, Aug 16, 2005

Filed:

Mar 24, 2003

Appl. No.:

10/395331

Inventors:

Paul Charifson - Framingham MA, US
Dean Stamos - Framingham MA, US
Michael Badia - Bedford MA, US
Anne Laure Grillot - Cambridge MA, US
Steven Ronkin - Watertown MA, US
Martin Trudeau - Tewksbury MA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

A61K031/427
C07D277/32

US Classification:

514342, 514340, 546193, 546194, 548202

Abstract:

The present invention relates to compounds of the formula I: where Ring A is a thiazole, oxazole, imidazole or pyrazole and the substituents are as described in the specification, and pharmaceutically acceptable salts thereof. The compounds inhibit bacterial gyrase activity and therefore are useful for treating bacterial infections in mammals.

US Patent:

7087642, Aug 8, 2006

Filed:

Nov 4, 2002

Appl. No.:

10/287405

Inventors:

Dean Stamos - Framingham MA, US
Martin Trudeau - Tewksbury MA, US
Scott Bethiel - Bedford MA, US
Steven Ronkin - Watertown MA, US
Michael Badia - Bedford MA, US
Jeffrey Saunders - Acton MA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

A61K 47/00
A61K 31/27
C07C 229/00
C07C 255/00

US Classification:

514476, 514784, 514785, 558417, 558414, 558411, 560 19, 560 24, 560 27, 560 34

Abstract:

The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

US Patent:

RE40245, Apr 15, 2008

Filed:

Apr 28, 2004

Appl. No.:

10/833995

Inventors:

Anne-Laure Grillot - Cambridge MA, US
Paul S. Charifson - Framingham MA, US
Dean Stamos - Carlsbad MA, US
Yusheng Liao - Lexington MA, US
Michael C. Badia - Bedford MA, US
Martin Trudeau - Tewksbury MA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

C07D 403/04
C07D 413/04
C07D 235/30
A61K 31/55

US Classification:

514215, 5142345, 51425214, 51425219, 514256, 514269, 514275, 514293, 514303, 514314, 514318, 514322, 514338, 514364, 514375, 514395, 540578, 544122, 544124, 544324, 544330, 544331, 544333, 546 82, 546118, 546167, 546193, 546199, 5462717, 5462731, 5462734, 548143, 548222, 5483047, 5483051, 5483081

Abstract:

The present invention relates to compounds of the formula I: or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also relates to methods for treating bacterial infections in mammala. The present invention also relates to methods for decreasing bacterial quantity in a biological sample.

US Patent:

7381827, Jun 3, 2008

Filed:

Mar 11, 2005

Appl. No.:

11/078147

Inventors:

Gerald J. Tanoury - Hudson MA, US
Minzhang Chen - Plainsboro NJ, US
Andrew D. Jones - Boston MA, US
Philip L. Nyce - Milbury MA, US
Martin Trudeau - Tewksbury MA, US
David J. Guerin - Natick MA, US
John R. Snoonian - Ayer MA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

C07D 207/06
C07D 295/02
C07D 305/00
C07C 239/00

US Classification:

548579, 548578, 549505, 564189, 564188

Abstract:

The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.

US Patent:

7414046, Aug 19, 2008

Filed:

May 23, 2003

Appl. No.:

10/444588

Inventors:

Anne-Laure Grillot - Cambridge MA, US
Paul Charifson - Framingham MA, US
Dean Stamos - Framingham MA, US
Yusheng Liao - Lexington MA, US
Michael Badia - Bedford MA, US
Martin Trudeau - Tewksbury MA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

C07D 403/04
C07D 413/04
C07D 235/30
A61K 31/55

US Classification:

514215, 5142345, 51425214, 51425219, 514256, 514269, 514275, 514293, 514303, 514314, 514318, 514322, 514338, 514364, 514375, 514395, 540578, 544122, 544124, 544324, 544330, 544331, 544333, 546 82, 546118, 546167, 546193, 546199, 5462717, 5462731, 5462734, 548143, 548222, 5483047, 5483051, 5483081

Abstract:

The present invention relates to compounds of the formula I:.

US Patent:

7432290, Oct 7, 2008

Filed:

Nov 24, 2004

Appl. No.:

10/997810

Inventors:

Dean Stamos - Framingham MA, US
Martin Trudeau - Tewksbury MA, US
Randy S. Bethiel - Lexington MA, US
Steven M. Ronkin - Watertown MA, US
Michael C. Badia - Bedford MA, US
Jeffrey O. Saunders - Acton MA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

A61K 31/41
A61K 31/425
C07D 263/00
C07D 263/02

US Classification:

514359, 514374, 548215, 548225

Abstract:

The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.