Mary C Betlach

US Patent:

6503741, Jan 7, 2003

Filed:

Aug 28, 1998

Appl. No.:

09/141908

Inventors:

Gary Ashley - Alameda CA
Melanie C. Betlach - Burlingame CA
Mary Betlach - San Francisco CA
Robert McDaniel - Palo Alto CA
Li Tang - Foster City CA

Assignee:

Kosan Biosciences, Inc. - Burlingame CA

International Classification:

C12N 900

US Classification:

435183, 43525233, 43525235, 4352542, 435189, 435193, 435232, 4353201, 536 232, 536 237, 536 231

Abstract:

Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for picromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.

US Patent:

6509455, Jan 21, 2003

Filed:

Sep 7, 2000

Appl. No.:

09/657440

Inventors:

Gary Ashley - Alameda CA
Melanie C. Betlach - Burlingame CA
Mary Betlach - San Francisco CA
Robert McDaniel - Palo Alto CA
Li Tang - Foster City CA

Assignee:

Kosan Biosciences, Inc. - Hayward CA

International Classification:

C07H 2104

US Classification:

536 232, 435193, 4353201, 536 237

Abstract:

Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyketides that are useful as antibiotics and as intermediates in the synthesis of compounds with pharmaceutical value.

US Patent:

6902913, Jun 7, 2005

Filed:

Feb 22, 2001

Appl. No.:

09/793708

Inventors:

Melanie C. Betlach - Burlingame CA, US
Mary Betlach - San Francisco CA, US
Robert McDaniel - Palo Alto CA, US
Li Tang - Foster City CA, US

Assignee:

Kosan Biosciences, Inc. - Hayward CA

International Classification:

C12P019/62
C07H021/04
C12N001/20

US Classification:

435 72, 435 76, 4352523, 43525233, 43525235, 4353201, 536 232, 536 237

Abstract:

Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyketides that are useful as antibiotics and as intermediates in the synthesis of compounds with pharmaceutical value.

US Patent:

20020002712, Jan 3, 2002

Filed:

May 1, 2001

Appl. No.:

09/847089

Inventors:

Mary Betlach - San Francisco CA, US
James Kealey - Davis CA, US
Neal Gutterson - Oakland CA, US
Ed Ralston - Pleasant Hill CA, US

International Classification:

C12N015/82
C12N005/14
A01H005/00

US Classification:

800/278000, 800/298000, 435/419000, 800/288000, 536/023740, 435/069700

Abstract:

The present invention provides genetically altered plants and plant cells that have been modified to contain expression system(s) capable of expressing a functional polyketide synthase (PKS). The present invention further provides methods of producing PKS and polyketides using these plants and cells.

US Patent:

20030027287, Feb 6, 2003

Filed:

Mar 14, 2001

Appl. No.:

09/808880

Inventors:

Mary Betlach - San Francisco CA, US
Sanjay Shah - Concord CA, US
Robert McDaniel - Palo Alto CA, US
Li Tang - Foster City CA, US

International Classification:

C12P019/62
C12N009/00
C07H021/04
C12P021/02
C12N005/06

US Classification:

435/076000, 435/069100, 435/183000, 435/320100, 435/325000, 536/023200

Abstract:

Recombinant DNA compounds that encode all or a portion of the oleandolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of oleandolide, oleandolide derivatives, and polyketides that are useful as antibiotics and motilides.

US Patent:

20030148469, Aug 7, 2003

Filed:

Jul 22, 2002

Appl. No.:

10/201365

Inventors:

Gary Ashley - Alameda CA, US
Melanie Betlach - Burlingame CA, US
Mary Betlach - San Francisco CA, US
Robert McDaniel - Palo Alto CA, US
Li Tang - Foster City CA, US

International Classification:

C12P019/62
C12P021/02
C12N001/21
C07H021/04
C12N009/10
C12N015/74

US Classification:

435/076000, 435/069100, 435/252300, 435/320100, 536/023200, 435/193000

Abstract:

Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for picromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.

US Patent:

20030162262, Aug 28, 2003

Filed:

May 29, 2002

Appl. No.:

10/160539

Inventors:

Gary Ashley - Alameda CA, US
Melanie Betlach - Burlingame CA, US
Mary Betlach - San Francisco CA, US
Robert McDaniel - Palo Alto CA, US
Li Tang - Foster City CA, US

International Classification:

C12P019/62
C12Q001/68
C07H021/04
C12N009/10
C12P021/02
C12N001/21
C12N015/74

US Classification:

435/076000, 435/006000, 435/069100, 435/193000, 435/252300, 435/320100, 536/023200

Abstract:

Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyketides that are useful as antibiotics and as intermediates in the synthesis of compounds with pharmaceutical value.

US Patent:

20050026244, Feb 3, 2005

Filed:

Feb 22, 2002

Appl. No.:

10/468828

Inventors:

Gary Ashley - Alameda CA, US
Melanie Betlach - San Francisco CA, US
Mary Betlach - San Francisco CA, US
Robert McDaniel - Palo Alto CA, US
Li Tang - Foster City CA, US

International Classification:

C12N009/10
C12N009/16
C07H021/04
C12N001/21

US Classification:

435069100, 435193000, 435196000, 435252300, 435320100, 536023200

Abstract:

Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyketides that are useful as antibiotics and as intermediates in the synthesis of compounds with pharmaceutical value.