Mary Theresa Macdonald

US Patent:

20060025438, Feb 2, 2006

Filed:

Feb 25, 2005

Appl. No.:

11/066786

Inventors:

Luisa Salter-Cid - San Diego CA, US
Eric Wang - San Diego CA, US
Mary MacDonald - San Diego CA, US
Jingjing Zhao - San Diego CA, US

International Classification:

A61K 31/4745
A61K 31/165
A61K 31/47
A61K 31/137

US Classification:

514303000, 514309000, 514620000, 514649000

Abstract:

Compositions and methods are disclosed for inhibiting semicarbazide-sensitive amine oxidase (SSAO), also known as vascular adhesion protein-1 (VAP-1). The compounds disclosed are amine-containing and amide-containing compounds. The compounds and compositions are useful for treatment of diseases, including inflammation, inflammatory diseases and autoimmune disorders.

US Patent:

20070078157, Apr 5, 2007

Filed:

Nov 20, 2006

Appl. No.:

11/602565

Inventors:

Luisa Salter-Cid - Princeton Junction NJ, US
Eric Wang - San Diego CA, US
Mary MacDonald - San Diego CA, US
Jingjing Zhao - San Diego CA, US

Assignee:

La Jolla Pharmaceutical Company - San Diego CA

International Classification:

A61K 31/4745
A61K 31/4704
A61K 31/40
A61K 31/16
A61K 31/165
A61K 31/137

US Classification:

514303000, 514309000, 514621000, 514616000, 514649000, 514408000

Abstract:

Compositions and methods are disclosed for inhibiting semicarbazide-sensitive amine oxidase (SSAO), also known as vascular adhesion protein-1 (VAP-1). The compounds disclosed are amine-containing and amide-containing compounds. The compounds and compositions are useful for treatment of diseases, including inflammation, inflammatory diseases and autoimmune disorders.

US Patent:

20070293548, Dec 20, 2007

Filed:

Mar 30, 2007

Appl. No.:

11/731819

Inventors:

Eric Wang - San Diego CA, US
David Jones - San Diego CA, US
Anne O'Rourke - Encinitas CA, US
Mary MacDonald - San Diego CA, US
Hongfeng Gao - San Diego CA, US
Huong-thu Ton-Nu - San Diego CA, US
Christina Kessler - San Diego CA, US
Matthew Linnik - Solana Beach CA, US

International Classification:

A61K 31/44
A61K 31/135
A61K 31/343
A61P 37/00
C07C 211/29
C07C 217/54
C07C 211/26
A61P 29/00
A61K 31/381

US Classification:

514357000, 514443000, 514469000, 514649000, 514651000, 564336000, 564346000, 564366000

Abstract:

Compositions and methods of using compositions for treatment of inflammatory diseases and immune disorders are provided. Allylamino compounds are disclosed which are inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and/or vascular adhesion protein 1 (VAP-1). The compounds have therapeutic utility in suppressing inflammation and inflammatory responses, and in treatment of several disorders, including multiple sclerosis and stroke.

US Patent:

20090203764, Aug 13, 2009

Filed:

Apr 20, 2009

Appl. No.:

12/426885

Inventors:

Eric Yanjun WANG - San Diego CA, US
David S. Jones - San Diego CA, US
Anne M. O'Rourke - Encinitas CA, US
Mary T. MacDonald - San Diego CA, US
Hongfeng Gao - San Diego CA, US
Huong-thu Ton-Nu - San Diego CA, US
Christina A. Kessler - San Diego CA, US
Matthew D. Linnik - Solana Beach CA, US

International Classification:

A61K 31/137
A61P 29/00
A61K 31/381

US Classification:

514438, 514649

Abstract:

Compositions and methods of using compositions for treatment of inflammatory diseases and immune disorders are provided. Allylamino compounds are disclosed which are inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and/or vascular adhesion protein 1 (VAP-1). The compounds have therapeutic utility in suppressing inflammation and inflammatory responses, and in treatment of several disorders, including multiple sclerosis and stroke.

US Patent:

20110236931, Sep 29, 2011

Filed:

Apr 14, 2009

Appl. No.:

12/937957

Inventors:

John R. Cashman - San Diego CA, US
Mary T. MacDonald - San Diego CA, US

Assignee:

HUMAN BIOMOLECULAR RESEARCH INSTITUTE - San Diego CA

International Classification:

C12P 21/00
C12P 21/08
C07K 19/00
C07K 7/06
C07K 7/08
C07K 14/00
C07F 9/40

US Classification:

435 7021, 435 702, 530409, 530329, 530328, 530327, 530326, 530325, 530324, 530395, 530363, 558172, 558190, 558166

Abstract:

Provided is a method to identify OP-adducted biomarkers of OP exposure as well as compounds containing OPs that can provide OP adducts.

US Patent:

20110269811, Nov 3, 2011

Filed:

May 3, 2011

Appl. No.:

13/100188

Inventors:

Eric Yanjun WANG - San Diego CA, US
David S. Jones - San Diego CA, US
Anne M. O'Rourke - Encinitas CA, US
Mary T. MacDonald - San Diego CA, US
Hongfeng Gao - San Diego CA, US
Huong-thu Ton-Nu - San Diego CA, US
Christina A. Kessler - San Diego CA, US
Matthew D. Linnik - Solana Beach CA, US

International Classification:

A61K 31/137
A61K 31/4035
A61P 29/00
A61P 25/00
A61P 1/00
A61P 1/04
A61P 25/28
A61P 9/10
A61P 19/02
A61P 11/06
A61P 17/00
A61P 1/16
A61P 3/10
A61P 9/04
A61P 37/00
A61K 31/145

US Classification:

514417, 514649

Abstract:

Compositions and methods of using compositions for treatment of inflammatory diseases and immune disorders are provided. Allylamino compounds are disclosed which are inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and/or vascular adhesion protein 1 (VAP-1). The compounds have therapeutic utility in suppressing inflammation and inflammatory responses, and in treatment of several disorders, including multiple sclerosis and stroke.

US Patent:

20120172392, Jul 5, 2012

Filed:

Mar 7, 2012

Appl. No.:

13/414644

Inventors:

LUISA M. SALTER-CID - PRINCETON JUNTION NJ, US
ERIC Y. WANG - SAN DIEGO CA, US
MARY T. MACDONALD - SAN DIEGO CA, US
JINGJING ZHAO - SAN DIEGO CA, US

International Classification:

A61K 31/164
A61K 31/166
C07D 217/24
A61K 31/472
C07D 209/46
A61K 31/4035
C07D 209/08
A61K 31/4045
C07D 249/18
A61K 31/4192
C07D 235/06
A61K 31/4184
C07D 231/56
A61K 31/416
C07C 211/30
A61K 31/137
C07D 207/20
A61K 31/40
C07D 213/30
A61K 31/4406
C07D 213/26
C07C 211/29
C07C 215/30
C07C 211/27
C07C 229/34
A61K 31/198
A61K 31/24
C07D 471/04
A61K 31/437
C07C 237/06
A61P 29/00
C07C 233/78

US Classification:

514303, 564187, 514617, 546141, 514309, 548472, 514416, 548469, 514415, 548257, 514359, 5483097, 514394, 5483625, 514406, 564387, 514655, 548565, 514408, 514428, 546339, 514277, 546346, 564366, 514649, 564355, 564381, 514653, 514654, 562449, 514567, 560 38, 514538, 546118, 564193, 514626

Abstract:

Compositions and methods are disclosed for inhibiting semicarbazide-sensitive amine oxidase (SSAO), also known as vascular adhesion protein-1 (VAP-1). The compounds disclosed are amine-containing and amide-containing compounds. The compounds and compositions are useful for treatment of diseases, including inflammation, inflammatory diseases and autoimmune disorders.

US Patent:

20170101441, Apr 13, 2017

Filed:

Dec 27, 2016

Appl. No.:

15/391614

Inventors:

- San Diego CA, US
Mary T. MacDonald - San Diego CA, US

Assignee:

Human BioMolecular Research Foundation - San Diego CA

International Classification:

C07K 7/06
C12P 21/00
C07K 16/18

Abstract:

Provided are methods for identifying OP-adducted biomarkers of OP exposure as well as compounds containing OPs that can provide OP adducts and compounds of Formula 1 for eliciting antibodies that specifically and selectively bind to the OP adducts, wherein the Formula 1 compounds have the structure of OP-Peptide-Linker-CP, wherein CP is a carrier protein, OP represents a structure corresponding to that of a reactive organic phosphorous compound covalently modifying a tyrosine residue hydroxyl group of the peptide of Formula I and the other variable groups are as described herein.