Mary Janay Michaels

US Patent:

20070003528, Jan 4, 2007

Filed:

Jun 29, 2005

Appl. No.:

11/170750

Inventors:

Paul Consigny - San Jose CA, US
Gabriel Asongwe - San Jose CA, US
Mary Michaels - Sunnyvale CA, US
Gene Michal - San Francisco CA, US
Evgenia Mandrusov - Santa Clara CA, US
Jeong Lee - Diamond Bar CA, US
Florian Ludwing - Mountain View CA, US
John Henckel - Houston TX, US
Joseph Sciacca - Houston TX, US
Ken Bueche - Friendswood TX, US
Richard Thornton - League City TX, US
Fidel Urrabazo - San Antonio TX, US
Daniel Wiegand - Houston TX, US

International Classification:

A61K 35/12
A61K 38/19
A61K 38/18
C12N 5/08

US Classification:

424093700, 435366000, 424085100, 514012000

Abstract:

Engraftment of therapeutic cells and agents to a target site in an organism is enhanced by mechanical, chemical and biological methods and systems.

US Patent:

20080206207, Aug 28, 2008

Filed:

Feb 7, 2008

Appl. No.:

12/027984

Inventors:

Paul Consigny - San Jose CA, US
Gabriel Asongwe - San Jose CA, US
Mary Beth Michaels - Sunnyvale CA, US
Gene Michal - San Francisco CA, US
Evgenia Mandrusov - Santa Clara CA, US
Jeong Lee - Diamond Bar CA, US
Florian Ludwig - Mountain View CA, US
John Eric Henckel - Houston TX, US
Joseph J. Sciacca - Houston TX, US
Ken Bueche - Friendswood TX, US
Richard Todd Thornton - League City TX, US
Fidel Albert Urrabazo - San Antonio TX, US
Daniel Wiegand - Houston TX, US

Assignee:

Advanced Cardiovascular Systems Inc. - Santa Clara CA

International Classification:

A61K 35/12
A61K 39/395
A61P 41/00

US Classification:

424 937, 4241301

Abstract:

Engraftment of therapeutic cells and agents to a target site in an organism is enhanced by mechanical, chemical and biological methods and systems.

US Patent:

20120064098, Mar 15, 2012

Filed:

Nov 17, 2011

Appl. No.:

13/299341

Inventors:

Paul Consigny - San Jose CA, US
Gabriel Asongwe - San Jose CA, US
Mary Beth Michaels - Sunnyvale CA, US
Gene Michal - San Francisco CA, US
Evgenia Mandrusov - Santa Clara CA, US
Jeong Lee - Diamond Bar CA, US
Florian Ludwig - Luzem, CH
John Eric Henckel - Houston TX, US
Joseph J. Sciacca - Houston TX, US
Ken Bueche - Friendswood TX, US
Richard Todd Thornton - League City TX, US
Fidel Albert Urrabazo - San Antonio TX, US
Daniel Wiegand - Houston TX, US

Assignee:

Advanced Cardiovascular Systems, Inc. - Santa Clara CA

International Classification:

A61K 47/48

US Classification:

4241781, 424 937

Abstract:

Engraftment of therapeutic cells and agents to a target site in an organism is enhanced by mechanical, chemical and biological methods and systems.

US Patent:

20120148609, Jun 14, 2012

Filed:

Feb 21, 2012

Appl. No.:

13/401796

Inventors:

Paul Consigny - San Jose CA, US
Gabriel Asongwe - San Jose CA, US
Mary Beth Michaels - Sunnyvale CA, US
Gene Michal - San Francisco CA, US
Evgenia Mandrusov - Santa Clara CA, US
Jeong Lee - Diamond Bar CA, US
Florian Ludwig - Mountain View CA, US
John Eric Henckel - Houston TX, US
Joseph J. Sciacca - Houston TX, US
Ken Bueche - Friendswood TX, US
Richard Todd Thornton - League City TX, US
Fidel Albert Urrabazo - San Antonio TX, US
Daniel Wiegand - Houston TX, US

Assignee:

ADVANCED CARDIOVASCULAR SYSTEMS INC. - Santa Clara CA

International Classification:

A61K 35/12
A61P 43/00
A61K 39/395

US Classification:

4241781, 424 937

Abstract:

Engraftment of therapeutic cells and agents to a target site in an organism is enhanced by mechanical, chemical and biological methods and systems.

US Patent:

20120148668, Jun 14, 2012

Filed:

Feb 21, 2012

Appl. No.:

13/401803

Inventors:

Paul Consigny - San Jose CA, US
Gabriel Asongwe - San Jose CA, US
Mary Beth Michaels - Sunnyvale CA, US
Gene Michal - San Francisco CA, US
Evgenia Mandrusov - Santa Clara CA, US
Jeong Lee - Diamond Bar CA, US
Florian Ludwig - Luzern CA, US
John Eric Henckel - Houston TX, US
Joseph J. Sciacca - Houston TX, US
Ken Bueche - Friendswood TX, US
Richard Todd Thornton - League City TX, US
Fidel Albert Urrabazo - San Antonio TX, US
Daniel Wiegand - Houston TX, US

Assignee:

ADVANCED CARDIOVASCULAR SYSTEMS INC. - Santa Clara CA

International Classification:

A61K 9/127
A61P 41/00
A61M 37/00
A61K 35/12

US Classification:

424450, 424 937, 604 24

Abstract:

Engraftment of therapeutic cells and agents to a target site in an organism is enhanced by mechanical, chemical and biological methods and systems.

US Patent:

20120157751, Jun 21, 2012

Filed:

Feb 21, 2012

Appl. No.:

13/401790

Inventors:

Paul Consigny - San Jose CA, US
Gabriel Asongwe - San Jose CA, US
Mary Beth Michaels - Sunnyvale CA, US
Gene Michal - San Francisco CA, US
Evgenia Mandrusov - Santa Clara CA, US
Jeong Lee - Diamond Bar CA, US
Florian Ludwig - Luzern, CH
John Eric Henckel - Houston TX, US
Joseph J. Sciacca - Houston TX, US
Ken Bueche - Friendswood TX, US
Richard Todd Thornton - League City TX, US
Fidel Albert Urrabazo - San Antonio TX, US
Daniel Wiegand - Houston TX, US

Assignee:

ADVANCED CARDIOVASCULAR SYSTEMS INC. - Santa Clara CA

International Classification:

A61N 2/10
A61P 9/00
A61N 2/08
A61K 35/12

US Classification:

600 12, 424 937, 600 9

Abstract:

Engraftment of therapeutic cells and agents to a target site in an organism is enhanced by mechanical, chemical and biological methods and systems.

US Patent:

56117752, Mar 18, 1997

Filed:

May 6, 1994

Appl. No.:

8/238904

Inventors:

Timothy R. Machold - Moss Beach CA
Janine C. Robinson - Half Moon Bay CA
Mary B. Michaels - Sunnyvale CA
Motasim M. Sirhan - Sunnyvale CA

Assignee:

Advanced Cardiovascular Systems, Inc. - Santa Clara CA

International Classification:

A61M 3100

US Classification:

604 53

Abstract:

A catheter and method of using the catheter for the delivery of therapeutic or diagnostic liquid within a body lumen of a patient. The catheter has an outer inflatable member which has a wall with a plurality of apertures which eject therapeutic or diagnostic liquid in a jet-like form deep within the lumenal tissue adjacent to the outer inflatable member. In one embodiment the catheter has an inner inflatable member disposed within the outer inflatable member which upon inflation expands the outer tubular member so as to dilatate a stenotic region of a body lumen such as an artery. The inflatable member may be provided with proximal and distal ends which expand to larger diameters than the central inflatable section so as to seal the larger ends and prevent the loss of fluid.

US Patent:

53422988, Aug 30, 1994

Filed:

Jul 31, 1992

Appl. No.:

7/923063

Inventors:

Mary B. Michaels - Sunnyvale CA
Janine C. Robinson - Half Moon Bay CA
John P. Claude - San Carlos CA
Donald L. Alden - Sunnyvale CA

Assignee:

Advanced Cardiovascular Systems, Inc. - Santa Clara CA

International Classification:

A61M 100

US Classification:

604 65

Abstract:

Providing fluid to an internal delivery site of a patient includes moving the fluid from a fluid reservoir through a conduit and through a delivery device at the delivery site while maintaining the fluid at a predetermined pressure. The delivery device may comprise an inflatable balloon with apertures formed in its periphery for directing the fluid into the vessel walls. Pressurized fluid is provided through the apertures of the balloon to the vessel wall. The pressure is automatically controlled to avoid both pressure spikes and unacceptable deflation of the balloon during administration of the fluid. A further feature includes comparing the pressure with the volume infused and in the event that pressure decreases while the volume infused increases beyond certain limits, the delivery of the fluid is stopped. Further features include a timer for limiting the inflation time of the delivery device and a volume detector for controlling the amount of fluid delivered. In one described embodiment, a pneumatic driver system is used to pressurize the fluid.