Mary E Zink

US Patent:

8512963, Aug 20, 2013

Filed:

Nov 23, 2010

Appl. No.:

12/953053

Inventors:

David Raymond Graham - Baltimore MD, US
Susan Christine Trow - Baltimore MD, US
Mary Christine Zink - Baltimore MD, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

G01N 33/53

US Classification:

435 71, 436518

Abstract:

The present invention relates, e. g. , to a method for detecting a full-length protein and a truncated form (e. g. , a naturally occurring cleavage product) thereof, in a sample, comprisingIn one embodiment of the invention, the full-length protein is thioredoxin (TRX), and the truncated form thereof is its biologically active, C-terminal truncated, 10 kDa cleavage product, TRX 80.

US Patent:

20090325909, Dec 31, 2009

Filed:

Sep 27, 2004

Appl. No.:

10/569887

Inventors:

Mary C. Zink - Ellicott City MD, US
Sheila A. Barber - Walkersville MD, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

A61K 31/65

US Classification:

514154, 514152

Abstract:

The invention provides a new and effective treatment for human immunodeficiency diseases, particularly for HIV-infected individuals. The treatment utilizes tetracycline analogs, particularly minocycline, in amounts that are effective to prevent HIV replication both the central nervous system and in peripheral blood.