Matthew A Coleman

US Patent:

8428398, Apr 23, 2013

Filed:

Jun 29, 2010

Appl. No.:

12/826215

Inventors:

Deanna Lynn Thompson - Orangevale CA, US
Matthew A. Coleman - Oakland CA, US
Stephen M. Lane - Oakland CA, US
Dennis L. Matthews - Gold River CA, US
Joanna Albala - Stockton CA, US
Sebastian Wachsmann-Hogiu - Sacramento CA, US

Assignee:

Lawrence Livermore National Security, LLC - Livermore CA
The Regents of the University of California - Oakland CA

International Classification:

G06K 9/22

US Classification:

382313, 348294

Abstract:

A hand-held portable microarray reader for biodetection includes a microarray reader engineered to be small enough for portable applications. The invention includes a high-powered light-emitting diode that emits excitation light, an excitation filter positioned to receive the excitation light, a slide, a slide holder assembly for positioning the slide to receive the excitation light from the excitation filter, an emission filter positioned to receive the excitation light from the slide, a lens positioned to receive the excitation light from the emission filter, and a CCD camera positioned to receive the excitation light from the lens.

US Patent:

20210317234, Oct 14, 2021

Filed:

May 5, 2021

Appl. No.:

17/308921

Inventors:

- Livermore CA, US
Wei HE - Davis CA, US
Kit S. LAM - Davis CA, US
Paul HENDERSON - Dublin CA, US
Matthew A. COLEMAN - Oakland CA, US

International Classification:

C07K 17/02
C07K 14/775

Abstract:

The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The membrane scaffold protein can be apolipoprotein. The telodendrimer has the general formula PEG-L-D-(R), wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a poly(ethylene glycol) polymer, each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Cell free methods of making the nanodiscs are also provided.

US Patent:

20180079829, Mar 22, 2018

Filed:

Apr 27, 2017

Appl. No.:

15/499855

Inventors:

- Livermore CA, US
Wei HE - Davis CA, US
Kit S. LAM - Davis CA, US
Paul HENDERSON - Dublin CA, US
Matthew A. COLEMAN - Oakland CA, US

International Classification:

C07K 17/02
C07K 14/775

Abstract:

The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The membrane scaffold protein can be apolipoprotein. The telodendrimer has the general formula PEG-L-D-(R), wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a polyethylene glycol) polymer; each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Cell free methods of making the nanodiscs are also provided.