Matthew Patrick Coleman

US Patent:

7585815, Sep 8, 2009

Filed:

Jul 1, 2004

Appl. No.:

10/884783

Inventors:

Peter T. Beernink - Walnut Creek CA, US
Matthew A. Coleman - Oakland CA, US
Brent W. Segelke - San Ramon CA, US

Assignee:

Lawrence Livermore National Security, LLC - Livermore CA

International Classification:

C40B 20/02
C40B 20/04
A23J 16/00
C12Q 1/68
C12P 21/06

US Classification:

506 3, 506 4, 435 6, 435 681, 530412

Abstract:

Methods, compositions, and kits for the cell-free production and analysis of proteins are provided. The invention allows for the production of proteins from prokaryotic sequences or eukaryotic sequences, including human cDNAs using PCR and IVT methods and detecting the proteins through fluorescence or immunoblot techniques. This invention can be used to identify optimized PCR and WT conditions, codon usages and mutations. The methods are readily automated and can be used for high throughput analysis of protein expression levels, interactions, and functional states.

US Patent:

7901623, Mar 8, 2011

Filed:

Sep 26, 2006

Appl. No.:

11/528286

Inventors:

Robin R. Miles - Danville CA, US
William J. Benett - Livermore CA, US
Matthew A. Coleman - Oakland CA, US
Francesca S. Pearson - Livermore CA, US
Shanavaz L. Nasarabadi - Livermore CA, US

Assignee:

Lawrence Livermore National Security, LLC - Livermore CA

International Classification:

G01N 33/00

US Classification:

422 58, 436164, 436169, 435 4, 4352871, 422 50, 422 55, 422 61, 422 681, 422104

Abstract:

A lateral flow strip assay apparatus comprising a housing; a lateral flow strip in the housing, the lateral flow strip having a receiving portion; a sample collection unit; and a reagent reservoir. Saliva and/or buccal cells are collected from an individual using the sample collection unit. The sample collection unit is immersed in the reagent reservoir. The tip of the lateral flow strip is immersed in the reservoir and the reagent/sample mixture wicks up into the lateral flow strip to perform the assay.

US Patent:

20060234272, Oct 19, 2006

Filed:

Mar 27, 2006

Appl. No.:

11/390584

Inventors:

Andrew Wyrobek - Walnut Creek CA, US
Matthew Coleman - Oakland CA, US
David Nelson - Oakland CA, US

International Classification:

C12Q 1/68

US Classification:

435006000

Abstract:

A method of predicting sensitivity to radiation comprises selecting at least one of a first panel of genes associated with increased chromosomal damage and a second panel of genes associated with reduced chromosomal damage. The tissue is exposed to radiation. The RNA of the tissue is measured providing measured RNA of the first panel of genes associated with increased chromosomal damage and providing measured RNA of the second panel of genes associated with reduced chromosomal damage. Sensitivity to radiation is predicted using at least one of the measured RNA of the first panel of genes associated with increased chromosomal damage and the measured RNA of the second panel of genes associated with reduced chromosomal damage.

US Patent:

20080076122, Mar 27, 2008

Filed:

Sep 26, 2006

Appl. No.:

11/528296

Inventors:

Andrew J. Wyrobek - Walnut Creek CA, US
Matthew A. Coleman - Oakland CA, US
David O. Nelson - Oakland CA, US
James Tucker - Novi MI, US

International Classification:

C12Q 1/68
C12P 19/34
G06F 19/00

US Classification:

435 6, 435 912, 702 20

Abstract:

A method of characterizing exposure to ionizing radiation, utilizing the steps of selecting a set of biomarker geness for characterizing exposure to ionizing radiation, and using the set of biomarker genes for characterizing exposure to ionizing radiation. The step of selecting a set of biomarker genes for characterizing exposure to ionizing radiation was developed utilizing a unique set of 420 oligonucleotide probes for human genes capable of discerning past exposure to different doses of ionizing radiation. The step of selecting a set of biomarker genes for characterizing exposure to ionizing radiation utilizes groupings of genes that represent candidate panels of mRNA biomarkers.

US Patent:

20090136937, May 28, 2009

Filed:

May 9, 2008

Appl. No.:

12/118530

Inventors:

Matthew A. COLEMAN - Oakland CA, US
Paul D. Hoeprich - Pleasanton CA, US
Erin S. Arroyo - Fairfax CA, US
Jenny A. Cappuccio - Livermore CA, US

International Classification:

C12Q 1/68
G01N 33/68
G01N 33/566
C12M 1/00
B01J 19/00
G01N 33/53

US Classification:

435 6, 436 86, 436501, 435 79, 422 681, 4352871, 4352872

Abstract:

Provided herein are methods and systems for the monitoring production of a target protein in of a nanolipoprotein particle (NLP) that also includes a scaffold protein and a membrane forming lipid. The target protein is capable of assuming an active form and an inactive form. Monitoring is performed by an indicator protein that is capable of assuming an active form and an inactive form, the active form associated with a detectable activity of the indicator protein, the detectable activity further associated with the active form of the target protein.

US Patent:

20110033439, Feb 10, 2011

Filed:

Aug 6, 2010

Appl. No.:

12/852358

Inventors:

PAUL L. JACKSON - LIVERMORE CA, US
BRIAN E. SOUZA - LIVERMORE CA, US
FELIZA A. BOURGUET - LIVERMORE CA, US
MATTHEW A. COLEMAN - OAKLAND CA, US

International Classification:

A61K 38/47
C12Q 1/37
C12Q 1/68
C12N 9/36
C12P 1/04
A61P 31/04
C12Q 1/34

US Classification:

424 9461, 435 24, 435 6, 435206, 435170, 435 18

Abstract:

Targeted antimicrobials are described and related, compositions, methods and systems.

US Patent:

20110059549, Mar 10, 2011

Filed:

May 9, 2008

Appl. No.:

12/118396

Inventors:

Matthew A. Coleman - Oakland CA, US
Paul D. Hoeprich - Pleasanton CA, US
Brent W. Segelke - San Ramon CA, US

International Classification:

G01N 33/566
C07K 2/00

US Classification:

436501, 530402

Abstract:

Provided herein are methods and systems for the production of a nanolipoprotein particle (NLP) that includes a scaffold protein a membrane forming lipid and optionally a target protein. At least one of the scaffold protein and target protein can be provided through an IVT system. The membrane forming lipid, scaffold protein and optionally the target protein can be assembled for a time and under conditions that allow obtaining high yield NLPs, NPLs with an increased solubility, an NLP of a controlled size, and/or an NLP having a size predetermined to include a pre-selected target protein.

US Patent:

20110297721, Dec 8, 2011

Filed:

May 25, 2011

Appl. No.:

13/115575

Inventors:

John William Cromie - Menlo Park CA, US
Matthew Stephen Coleman - Los Angeles CA, US

Assignee:

ATLAS LOAD BEARING EQUIPMENT, INC. - Menlo Park CA

International Classification:

A45C 13/30

US Classification:

224660

Abstract:

A load bearing device for human use include first and second load bearing plates that have a first uncompressed position and a second compressed position that conform to the anatomy of the hips of a human. The plates are sufficiently rigid so as to prevent local inversion when the plates are subject to point or line loads and so as to distribute local loads over the plates. The plates can be used with belts, clothes, backpacks and other load carrying devices and can be incorporated into belts, clothes, backpacks and other load carrying devices.