Matthew D Doyle

US Patent:

6350438, Feb 26, 2002

Filed:

Jun 30, 2000

Appl. No.:

09/607242

Inventors:

Jonathan James Witt - Cincinnati OH
Rohan Lalith Wimalasena - Liberty Twp. OH
Andrew Lee Wong - West Chester OH
Matthew Joseph Doyle - Cincinnati OH

Assignee:

The Procter Gamble Company - Cincinnati OH

International Classification:

A61K 716

US Classification:

424 53, 424 49

Abstract:

The present invention relates to topical oral compositions, including therapeutic rinses, especially mouth rinses, as well as toothpastes, gels, tooth powders, chewing gums, mouth sprays, lozenges (including breath mints), dental implements (such as dental floss and tape), and pet care products comprising at least a minimally effective amount of chlorite ion, wherein the pH of the final composition is greater than 7 and the composition is essentially free of chlorine dioxide or chlorous acid. This invention further relates to a method for treating or preventing diseases and conditions of the oral cavity such as gingivitis, plaque, periodontal disease, herpetic lesions, and infections that may develop following dental procedures such as osseous surgery, tooth extraction, periodontal flap surgery, dental implantation, and scaling and root planing, in humans and other animals, by applying a safe and effective amount of the chlorite ion composition to the oral cavity.

US Patent:

6846478, Jan 25, 2005

Filed:

Jun 30, 2000

Appl. No.:

09/607729

Inventors:

Matthew Joseph Doyle - Cincinnati OH, US
Stephen Joseph Hunter-Rinderle - Mason OH, US
Rohan Lalith Wimalasena - Liberty Township OH, US

Assignee:

The Procter & Gamble Company - Cincinnati OH

International Classification:

A61K 716

US Classification:

424 49

Abstract:

The present invention relates to promoting whole body health in humans and animals by using topical oral compositions comprising a safe and effective amount of chlorite ion in admixture with a pharmaceutically acceptable carrier, said compositions being effective in controlling bacterial-mediated diseases and conditions present in the oral cavity and inhibiting the spread into the bloodstream of oral pathogenic bacteria and associated bacterial toxins and resultant inflammatory cytokines and mediators. The present invention also encompasses methods of use of these compositions by topically applying to the oral cavity, a safe and effective amount of chlorite ion to promote and/or enhance whole body health in humans and other animals.

US Patent:

8277782, Oct 2, 2012

Filed:

Apr 24, 2006

Appl. No.:

11/409850

Inventors:

Matthew Joseph Doyle - Cincinnati OH, US
Stephen Joseph Hunter-Rinderle - Mason OH, US

Assignee:

The Procter & Gamble Company - Cincinnati OH

International Classification:

A61K 7/16

US Classification:

424 49, 424 58

Abstract:

The present invention relates to topical oral care compositions comprising in a pharmaceutically acceptable carrier a safe and effective amount of a host-response modulating agent including one or more of an anti-oxidant and modifier of cell redox status, anti-inflammatory agent, metalloproteinase inhibitor, vitamins and nutrients key to maintenance of a host response balance and inhibitor of activation of NF-kB in combination with one or a mixture of additional oral therapeutic actives selected from antimicrobial/antiplaque agents, biofilm inhibiting agents, antibiotics; analgesics and local anesthetic agents; dentinal desensitizing agents and odor masking agents. The present compositions are effective in treating and preventing bacteria-mediated diseases present in the oral cavity and in mediating host reaction to the presence of pathogenic bacteria in the oral cavity as well as the toxins and endotoxins, inflammatory cytokines and mediators released or prompted by these oral pathogens. By controlling bacteria-mediated diseases and conditions present in the oral cavity and modulating host reaction, spread into the bloodstream and other parts of the body of pathogenic bacteria and associated harmful substances is prevented or minimized.

US Patent:

8283135, Oct 9, 2012

Filed:

Nov 10, 2006

Appl. No.:

11/595530

Inventors:

Matthew Joseph Doyle - Cincinnati OH, US
Leo Timothy Laughlin - Mason OH, US
Todd Laurence Underiner - Cincinnati OH, US
Begonia Y. Ho - Cincinnati OH, US
Rowan Andrew Grayling - Loveland OH, US

Assignee:

The Procter & Gamble Company - Cincinnati OH

International Classification:

A61K 7/16

US Classification:

435 49

Abstract:

The present invention encompasses topical oral care compositions comprising the combination of an anti-bacterial agent with an anti-inflammatory agent in an orally acceptable carrier for effective treatment and prevention of bacteria-mediated diseases and conditions in the oral cavity and for modulating host reaction to bacterial pathogens present in the oral cavity and to the toxins, endotoxins, inflammatory cytokines and mediators released by or prompted by these pathogens. The present invention also encompasses methods of use of these compositions comprising topical application to the oral cavity. The benefits of the present compositions and methods extend beyond treating and preventing oral bacterial infections in the oral cavity to promoting whole body or systemic health.

US Patent:

20050163727, Jul 28, 2005

Filed:

May 25, 2004

Appl. No.:

10/854065

Inventors:

Matthew Doyle - Cincinnati OH, US
Stephen Hunter-Rinderle - Mason OH, US
Robert Singer - Fairfield OH, US

International Classification:

A61K009/68
A61K007/16
A61K007/20
A61K031/44
A01N033/12

US Classification:

424048000, 424049000, 424650000, 514358000, 514166000, 514643000

Abstract:

The present invention relates to promoting whole body health in humans and animals by using topical oral compositions comprising a safe and effective amount of an antimicrobial agent in admixture with a pharmaceutically acceptable carrier, said compositions being effective in controlling bacterial-mediated diseases and conditions present in the oral cavity and in inhibiting the spread into the bloodstream of pathogenic oral bacteria, associated bacterial toxins and endotoxins, and resultant inflammatory cytokines and mediators. The present invention also encompasses methods of use of these compositions by topically applying to the oral cavity, a safe and effective amount of an antimicrobial agent to promote and/or enhance whole body health in humans and other animals.

US Patent:

20060283478, Dec 21, 2006

Filed:

Aug 21, 2006

Appl. No.:

11/507150

Inventors:

Ruben Avila - Mason OH, US
Daniel Volpenhein - Mason OH, US
Margaret O'Donoghue - Monroe OH, US
Matthew Doyle - Cincinnati OH, US
Chanchal Ghosh - West Chester OH, US
Rowan Grayling - Loveland OH, US
Aleksey Pinyayev - West Chester OH, US

International Classification:

A61C 15/00

US Classification:

132321000

Abstract:

Disclosed are various oral care devices and methods. One method includes introducing a composition into the oral cavity, wherein the composition includes a reactive species generating agent. Output from a light emitting element is directed at a portion of the soft tissue of the oral cavity for a period of time sufficient to generate one or more reactive species from the reactive species generating agent.

US Patent:

20070140987, Jun 21, 2007

Filed:

Feb 1, 2007

Appl. No.:

11/701848

Inventors:

Matthew Doyle - Cincinnati OH, US
Stephen Hunter-Rinderle - Mason OH, US
Robert Singer - Fairfield OH, US

International Classification:

A61K 9/68
A61K 31/4745
A61K 8/00
A23K 1/165
A61K 31/44

US Classification:

424049000, 424048000, 424442000, 424641000, 424650000, 514358000, 424638000, 514012000, 514283000

Abstract:

The present invention relates to promoting whole body health in humans and animals by using topical oral compositions comprising a safe and effective amount of an antimicrobial agent in admixture with a pharmaceutically acceptable carrier, said compositions being effective in controlling bacterial-mediated diseases and conditions present in the oral cavity and in inhibiting the spread into the bloodstream of pathogenic oral bacteria, associated bacterial toxins and endotoxins, and resultant inflammatory cytokines and mediators. The present invention also encompasses methods of use of these compositions by topically applying to the oral cavity, a safe and effective amount of an antimicrobial agent to promote and/or enhance whole body health in humans and other animals.

US Patent:

20110306018, Dec 15, 2011

Filed:

Aug 23, 2011

Appl. No.:

13/215719

Inventors:

Matthew Jospeh Doyle - Cincinnati OH, US
Stephen Joseph Hunter-Rinderle - Mason OH, US

International Classification:

A61C 17/00
A61K 31/155
A61P 29/00
A61P 11/00
A61P 31/00
A61P 9/00
A61K 31/4425
A61P 43/00

US Classification:

433216, 424 49, 424 54, 424 48

Abstract:

The present invention relates to promoting whole body health in humans and animals by using topical oral compositions comprising a safe and effective amount of an antimicrobial agent in admixture with a pharmaceutically acceptable carrier, said compositions being effective in controlling bacterial-mediated diseases and conditions present in the oral cavity and in inhibiting the spread into the bloodstream of pathogenic oral bacteria, associated bacterial toxins and endotoxins, and resultant inflammatory cytokines and mediators. The present invention also encompasses methods of use of these compositions by topically applying to the oral cavity, a safe and effective amount of an antimicrobial agent to promote and/or enhance whole body health in humans and other animals.