Matthew A Glassman

US Patent:

20140024722, Jan 23, 2014

Filed:

Oct 5, 2011

Appl. No.:

13/253485

Inventors:

Bradley D. Olsen - Arlington MA, US
Matthew J. Glassman - Cambridge MA, US
Jacqueline Chan - Arcadia CA, US

Assignee:

MASSACHUSETTS INSTITUTE OF TECHNOLOGY - CAMBRIDGE MA

International Classification:

A61K 47/42

US Classification:

5147721, 525 541

Abstract:

Described herein are block copolymer conjugates that form double-network hydrogels under appropriate conditions. The conjugates comprise a block of polymer end-group, a block of self-associating peptide or protein, and flexible linkers between the two. Hydrogels comprising the conjugates have the mechanical properties, including elastic modulus and fracture toughness, required for load-bearing applications, while maintaining desirable shear-thinning properties, for example, for injectability.