Matthew P Levy

US Patent:

20130123478, May 16, 2013

Filed:

Apr 29, 2011

Appl. No.:

13/643408

Inventors:

Matthew Levy - New Rochelle NY, US
Amy Yan - New Rochelle NY, US
Brian Wengerter - Bronx NY, US

International Classification:

C07H 21/04

US Classification:

536 231, 536 253

Abstract:

The present invention provides methods of preparing an oligonucleotide, nucleoside or nucleoside analog for selective introduction into a subject's cells, the method comprising (1) selecting a targeted aptamer, internalizing nucleic acid or tumor-homing nucleic acid via iterative rounds of selection, and (i) hybridizing it to an oligonucleotide, (ii) replacing one or more nucleotide with a nucleoside or nucleoside analog, or (iii) synthesizing the it with one or more nucleoside or nucleoside analogs; or (2) preparing a naive combinatorial aptamer, internalizing nucleic acid or tumor-homing nucleic acid prodrug library, and running iterative rounds of selection for the cells. The present invention also provides the agent, the pharmaceutical composition, and methods of treating or preventing cancer and/or viral infection, the method comprising administration of the oligonucleotide, nucleoside or nucleoside analog for selective introduction into a subject's cells.

US Patent:

20170304200, Oct 26, 2017

Filed:

Oct 7, 2015

Appl. No.:

15/510285

Inventors:

- Bronx NY, US
Matthew Levy - New Rochelle NY, US

Assignee:

ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. - Bronx NY

International Classification:

A61K 9/107
A61K 47/26

Abstract:

Methods and compositions for serum-stabilizing micelles for drug delivery or imaging agent delivery are provided, as well as methods and compositions to enhance micelle-mediated drug delivery. This invention provides a process for synthesizing a lipid micelle comprising one or more lipid-oligonucleotide conjugate molecules, the process comprising contacting an amount of lipid molecules with an amount of lipid-oligonucleotide conjugate molecules sufficient to create a lipid micelle comprising lipid-oligonucleotide conjugate molecules.

US Patent:

20160266133, Sep 15, 2016

Filed:

Oct 28, 2014

Appl. No.:

15/032672

Inventors:

Matthew LEVY - New Rochelle NY, US
- Bronx NY, US
Matthew Levy - New Rochelle NY, US

Assignee:

Albert Einstein College of Medicine, Inc. - Bronx NY

International Classification:

G01N 33/68
C12Q 1/68
C07H 21/04

Abstract:

Methods and compositions are provided for identifying novel ligands for a protein target.

US Patent:

20140363493, Dec 11, 2014

Filed:

Jun 9, 2014

Appl. No.:

14/299194

Inventors:

- Bronx NY, US
Joseph Katakowski - Bronx NY, US
Matthew Levy - Bronx NY, US
Teresa DiLorenzo - Bayside NY, US

Assignee:

ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY - Bronx NY

International Classification:

A61K 31/713
A61K 47/48

US Classification:

424450, 4241351

Abstract:

The present invention addresses a need for improved vehicles for delivering small interfering RNAs (siRNAs).