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The present invention is concerned with isoxazole-pyrazoles of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as therapeutics. The active compounds of the present invention are useful as cognitive enhancer or for the therapeutic and/or prophylactic treatment of cognitive disorders like Alzheimer's disease.
The present invention is concerned with isoxazole-isoxazoles and isoxazole-isothiazoles of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as cognitive enhancers or for the therapeutic and/or prophylactic treatment of cognitive disorders like Alzheimer's disease.
The present invention is concerned with isoxazole-thiazole derivatives of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful as cognitive enhancer or for the therapeutic and/or prophylactic treatment of cognitive disorders like Alzheimer's disease.
Bernd Buettelmann - Schopfheim, DE Stephen Deems Gabriel - Morristown NJ, US Steven Paul Hanlon - Bottmingen, CH Roland Jakob-Roetne - Inzlingen, DE Matthew C. Lucas - Verona NJ, US Paul Spurr - Riehen, CH Andrew Thomas - Binningen, CH Pius Waldmeier - Wegenstetten, CH
Assignee:
Hoffmann-La Roche Inc. - Nutley NJ
International Classification:
C07D 413/02 A61K 31/44
US Classification:
5142272, 514340, 544 582, 5462721
Abstract:
The present invention is concerned with novel hydroxy-methyl isoxazole derivatives of formula I.
Steven Berthel - Mendham NJ, US Fariborz Firooznia - Florham Park NJ, US Daniel Fishlock - Verona NJ, US Jun-Bae Hong - Ridgewood NJ, US Yan Lou - Clifton NJ, US Matthew Lucas - Verona NJ, US Timothy D. Owens - Jersey City NJ, US Keshab Sarma - Kinnelon NJ, US Zachary Kevin Sweeney - Redwood City CA, US Joshua Paul Gergely Taygerly - San Francisco CA, US
Assignee:
Roche Palo Alto LLC - Palo Alto CA
International Classification:
A61K 31/502 C07D 237/32
US Classification:
514248, 544237
Abstract:
This application discloses 5-phenyl-1H-pyridin-2-one, 6-phenyl-2H-pyridazin-3-one, and 5-Phenyl-1H-pyrazin-2-one derivatives according to generic Formula I-III:.
Bernd Buettelmann - Schopfheim, DE Roland Jakob-Roetne - Inzlingen, DE Henner Knust - Rheinfelden, DE Matthew C. Lucas - Verona NJ, US Andrew Thomas - Binningen, CH
Assignee:
Hoffmann-La Roche Inc. - Nutley NJ
International Classification:
A61K 31/4427 C07D 413/12
US Classification:
514340, 5462681, 5462684, 5462721, 514336
Abstract:
The present invention is concerned with novel isoxazoles of formula I.
Isoxazoles / O-Pyridines With Ethyl And Ethenyl Linker
University of St. Thomas (Tx) 1995 - 1997
Master of Business Administration, Masters, Finance
University of South Florida 1987 - 1991
Bachelors, Finance
Skills:
Contract Negotiation Budgets Customer Service Strategic Planning Negotiation Sales Construction New Business Development Sales Management Team Building
Microsoft Office Weld Natural Gas Pipelines Gas Engineering Onshore Inspection Ndt Refinery Petroleum Piping Metal Fabrication Oil/Gas Welding Upstream Construction Safety Supervisory Skills Corrosion Asme Certified Welding Inspector Petrochemical Energy Construction Epc Factory Oil and Gas Industry Offshore Drilling Completion Pressure Vessels Lng Pressure Subsea Engineering Energy Industry Fpso Commissioning Valves Drilling Boilers Tanks Safety Management Systems Project Engineering Project Control Refineries Oil
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Matthew Lucas
Lived:
Somerville, MA Champaign, IL Cambridge, MA San Francisco, CA New York, NY Seattle, WA Redmond, WA Bellevue, WA Park Ridge, IL
Work:
Cravath, Swaine & Moore - Summer Associate Microsoft - Program Manager Orrick, Herrington & Sutcliffe - Summer Associate
Education:
Harvard Law School, University of Illinois at Urbana-Champaign - Computer Engineering
Matthew Lucas
Lived:
Miami, FL Grove City, PA New York, NY Astoria, NY
Work:
Marymount Manhattan College - Student Financial Services Supervisor (2008)
Education:
Marymount Manhattan College - Writing
Tagline:
Let it be.
Bragging Rights:
Didn't start the fire.
Matthew Lucas
Education:
University of North Texas - Criminal Justice, Tarrant County College
Relationship:
In_a_relationship
Tagline:
I am a college student, currently attending the University of North Texas.
Bragging Rights:
Served 4 years in the United States Marine Corps and did 2 deployments to Iraq
Matthew Lucas
Work:
John Lewis - Presentation Designer (2004)
Education:
The Compton School
Matthew Lucas
Education:
Fuller Theological Seminary - Mdiv, Colorado School of Mines - Engineering