Matthew D Lucas

US Patent:

20130109661, May 2, 2013

Filed:

Oct 31, 2012

Appl. No.:

13/665006

Inventors:

Andreas Kuglstatter - Loerrach, DE
Matthew C. Lucas - Lexington MA, US
Fernando Padilla - Verona NJ, US
Jutta Wanner - Montclair NJ, US
Xiaohu Zhang - Suzhou, CN

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07D 487/04
A61K 45/06
A61K 31/625
A61K 31/5025
A61K 31/5377

US Classification:

514161, 544236, 514248, 544117, 5142332

Abstract:

The present invention relates to the use of novel compounds of formula I:wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.

US Patent:

20220298168, Sep 22, 2022

Filed:

Sep 22, 2020

Appl. No.:

17/028778

Inventors:

- Cambridge MA, US
Matthew LUCAS - Lexington MA, US
Kerem OZBOYA - Cambridge MA, US
Bhaumik PANDYA - Bedford MA, US
Daniel TARDIFF - Arlington MA, US
Parcharee TIVITMAHAISOON - Boston MA, US
Iwona WRONA - Sharon MA, US

International Classification:

C07D 491/107
C07D 237/04
C07D 401/12
C07D 237/24
C07D 213/82
C07D 403/12
C07D 409/14
C07D 487/04
C07D 401/14
C07D 471/04
C07D 405/14
C07D 413/12
C07D 417/12
C07D 513/04
C07D 417/14
C07D 495/04

Abstract:

The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

US Patent:

20230116101, Apr 13, 2023

Filed:

Nov 13, 2020

Appl. No.:

17/776952

Inventors:

- Boston MA, US
Kerem OZBOYA - Cambridge MA, US
Matthew LUCAS - Lexington MA, US
Bhaumik PANDYA - Bedford MA, US
Bertrand LE BOURDONNEC - Northborough MA, US

International Classification:

A61K 31/501
A61K 31/4545
A61K 31/497
A61K 31/454
A61K 31/55
A61K 31/4439
A61K 31/4188
A61K 31/17
A61K 39/395
A61K 31/436
A61K 31/439
A61K 31/166

Abstract:

The present invention features compounds useful in the treatment of neurological disorders and primary brain cancer. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders and primary brain cancer.

US Patent:

20230078764, Mar 16, 2023

Filed:

Mar 20, 2020

Appl. No.:

17/441937

Inventors:

- Boston MA, US
Matthew LUCAS - Lexington MA, US
Kerem OZBOYA - Cambridge MA, US
Bhaumik PANDYA - Bedford MA, US
Daniel TARDIFF - Arlington MA, US
Parcharee TIVITMAHAISOON - Boston MA, US
Iwona WRONA - Sharon MA, US

International Classification:

A61K 31/4439
A61K 31/495
A61K 31/17
A61K 31/436
A61K 31/475
A61K 31/166
A61K 39/395
C07D 401/12
C07D 495/04
C07D 417/12
C07D 405/14
C07D 413/12
C07D 401/14
C07D 213/75
A61K 31/501
A61K 31/506
A61K 31/444
A61K 31/497
A61K 31/519
A61K 31/44

Abstract:

The present invention features compounds useful in the treatment of neurological disorders and primary brain cancer. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders and primary brain cancer.

US Patent:

20210139471, May 13, 2021

Filed:

Jan 24, 2020

Appl. No.:

16/751803

Inventors:

- Cambridge MA, US
Kerem OZBOYA - Cambridge MA, US
Matthew LUCAS - Lexington MA, US
Bhaumik PANDYA - Bedford MA, US
Bertrand LE BOURDONNEC - Northborough MA, US

International Classification:

C07D 413/14
C07D 401/12
C07D 403/12
C07D 417/14
C07D 413/04
C07D 401/06
A61P 35/04

Abstract:

The present invention features compounds useful in the treatment of neurological disorders and primary brain cancer. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders and primary brain cancer.

US Patent:

20190388397, Dec 26, 2019

Filed:

Jun 21, 2019

Appl. No.:

16/448439

Inventors:

- Cambridge MA, US
Bhaumik PANDYA - Bedford MA, US
Daniel TARDIFF - Arlington MA, US
Jeff PIOTROWSKI - Somerville MA, US
Matthew LUCAS - Lexington MA, US
Bertrand LE BOURDONNEC - Northborough MA, US
Kenneth RHODES - Belmont MA, US
Robert SCANNEVIN - Hopkinton MA, US

International Classification:

A61K 31/4196
C12N 15/113
C07K 16/40
A61K 31/496
A61K 31/506
A61K 31/4164
A61K 31/704
A61K 31/575
A61K 31/4178

Abstract:

The invention provides compositions and methods for treating neurological disorders, such as amyotrophic lateral sclerosis, frontotemporal degeneration, and Alzheimer's disease, among others. Using the compositions and methods described herein, a patient having a neurological disorder, such as a neurological disorder associated with TAR-DNA binding protein (TDP)-43 aggregation, may be administered an inhibitor of cytochrome P450 (CYP450) isoform 51A1 (CYP51A1), also referred to herein as lanosterol 14-alpha demethylase, so as to treat an underlying etiology of the disorder and/or to alleviate one or more symptoms of the disease. The inhibitor of CYP51A1 may be a small molecule, anti-CYP51A1 antibody or antigen-binding fragment thereof, or a compound, such as an interfering RNA molecule, that attenuates CYP51A1 expression. Patients that may be treated using the compositions and methods described herein include those that express a mutant TDP-43 isoform containing a mutation associated with TDP-43-promoted aggregation and toxicity.

US Patent:

20190330198, Oct 31, 2019

Filed:

Apr 24, 2019

Appl. No.:

16/393183

Inventors:

- Cambridge MA, US
Parcharee TIVITMAHAISOON - Boston MA, US
Daniel TARDIFF - Arlington MA, US
Bhaumik PANDYA - Bedford MA, US
Kerem OZBOYA - Cambridge MA, US
Matthew LUCAS - Lexington MA, US
Bertrand Le BOURDONNEC - Northborough MA, US

International Classification:

C07D 413/14
C07D 413/06
C07D 413/12
C07D 261/08
C07D 491/107
C07D 487/04
C07D 417/14
C07D 487/10

Abstract:

The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

US Patent:

20180193325, Jul 12, 2018

Filed:

Jan 5, 2018

Appl. No.:

15/863773

Inventors:

- Cambridge MA, US
Daniel TARDIFF - Arlington MA, US
Jeff PIOTROWSKI - Somerville MA, US
Eric SOLIS - Milford MA, US
Robert SCANNEVIN - Hopkinton MA, US
Rebecca ARON - Cambridge MA, US
Bertrand LE BOURDONNEC - Northborough MA, US
Matthew LUCAS - Lexington MA, US
Kenneth RHODES - Belmont MA, US

International Classification:

A61K 31/454
A61P 25/28
G01N 33/68
A61K 45/06
A61K 31/4545
A61P 25/14
A61P 25/16

Abstract:

The present disclosure provides compounds and methods useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.