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The present invention is concerned with isoxazole-pyrazoles of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as therapeutics. The active compounds of the present invention are useful as cognitive enhancer or for the therapeutic and/or prophylactic treatment of cognitive disorders like Alzheimer's disease.
The present invention is concerned with isoxazole-isoxazoles and isoxazole-isothiazoles of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as cognitive enhancers or for the therapeutic and/or prophylactic treatment of cognitive disorders like Alzheimer's disease.
The present invention is concerned with isoxazole-thiazole derivatives of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful as cognitive enhancer or for the therapeutic and/or prophylactic treatment of cognitive disorders like Alzheimer's disease.
Bernd Buettelmann - Schopfheim, DE Roland Jakob-Roetne - Inzlingen, DE Henner Knust - Rheinfelden, DE Matthew C. Lucas - Verona NJ, US Andrew Thomas - Binningen, CH
Assignee:
Hoffmann-La Roche Inc. - Nutley NJ
International Classification:
A61K 31/4427 C07D 413/12
US Classification:
514340, 5462681, 5462684, 5462721, 514336
Abstract:
The present invention is concerned with novel isoxazoles of formula I.
Isoxazoles / O-Pyridines With Ethyl And Ethenyl Linker
Matthew C. Lucas - Verona NJ, US Andrew Thomas - Binningen, CH
Assignee:
Hoffmann-La Roche Inc. - Nutley NJ Roche Palo Alto LLC - Palo Alto CA
International Classification:
A61K 31/501 C07D 413/12 C07D 413/14
US Classification:
51425201, 544238
Abstract:
The present invention is concerned with isoxazole-pyridazines of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful as cognitive enhancer or for the therapeutic and/or prophylactic treatment of cognitive disorders like Alzheimer's disease.
Roland Jakob-Roetne - Inzlingen, DE Matthew C. Lucas - Verona NJ, US Andrew Thomas - Binningen, CH
Assignee:
Hoffmann-La Roche Inc. - Nutley NJ Roche Palo Alto LLC - Palo Alto CA
International Classification:
A61K 31/443 C07D 413/14
US Classification:
514333, 546256
Abstract:
The present invention is concerned with isoxazole-pyridines of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as pharmaceuticals. The active compounds of the present invention are useful as cognitive enhancer or for the therapeutic and/or prophylactic treatment of cognitive disorders like Alzheimer's disease.
Name / Title
Company / Classification
Phones & Addresses
Matthew Lucas President
Lucas Electric Co Inc Legal Services
415 Mercer St, New York, NY 10019
Matthew Lucas Teacher-adaptive Pe
Fairfax County Public Schools Elementary and Secondary Schools
3001 Chichester Ln, Fairfax, VA 22031
Matthew Lucas President
Lucas Electric Co Inc
415 Mercer St, New York, NY 10019 (609)4485218, (212)8395999
Matthew Lucas Treasurer
Greater Grace Family Ministries Church Religious Organization
Independent Roofing Co Reisterstown, MD 2008 to 2013 GENERAL MANAGERLord & Taylor
Dec 2003 to Mar 2008 Area Sales ManagerLord & Taylor Gaithersburg, MD 1998 to 2008 MANAGERLord & Taylor
Feb 2003 to Dec 2003 Area Sales ManagerLord & Taylor
Sep 2001 to Feb 2003 Executive In-Training Area Sales ManagerLord & Taylor Columbia, MD Oct 1998 to Sep 2001 Sales Associate
Education:
Wild Lake High School, Howard County MD 1996 to 1999 Attended and graduated with DiplomaSixSigma.us Iacet Project Management Institute 2014 Certificate of completion Black Belt of Six Sigma MethodologySixSigma.us Iacet Project Management Institute 2014 Certificate of Completion Green Belt of Six Sigma Methodology
Skills:
Inventory Management, Ops/Hr Management On the job training and related seminars Microsoft Office Suite (2003, 2007, 2013, Office 360), QuickBooks, Desktop/PC Computer Troubleshooting
Living Earth School Charlottesville, VA May 2011 to Aug 2013 CounselorUniversity of Maine Orono, ME Oct 2011 to May 2012 Lab TechnicianR.E.M Association services Crystal City, VA Nov 2011 to Dec 2011 Office Administrative AssistantCorn Maze in the Plains The Plains, VA Oct 2004 to Nov 2010 Corn CopFairfax County Public Schools Fairfax County, VA Sep 2008 to Aug 2010 Light and Sound Technician
Education:
University of Maine Orono, ME 2011 to 2015 BS in Food science and Nutrition
Googleplus
Matthew Lucas
Lived:
Somerville, MA Champaign, IL Cambridge, MA San Francisco, CA New York, NY Seattle, WA Redmond, WA Bellevue, WA Park Ridge, IL
Work:
Cravath, Swaine & Moore - Summer Associate Microsoft - Program Manager Orrick, Herrington & Sutcliffe - Summer Associate
Education:
Harvard Law School, University of Illinois at Urbana-Champaign - Computer Engineering
Matthew Lucas
Lived:
Miami, FL Grove City, PA New York, NY Astoria, NY
Work:
Marymount Manhattan College - Student Financial Services Supervisor (2008)
Education:
Marymount Manhattan College - Writing
Tagline:
Let it be.
Bragging Rights:
Didn't start the fire.
Matthew Lucas
Lived:
Fairfax, Virginia Blacksburg, Virginia Roanoke, Virginia
Education:
Virginia Tech
Relationship:
Married
Matthew Lucas
Education:
University of North Texas - Criminal Justice, Tarrant County College
Relationship:
In_a_relationship
Tagline:
I am a college student, currently attending the University of North Texas.
Bragging Rights:
Served 4 years in the United States Marine Corps and did 2 deployments to Iraq
Matthew Lucas
Work:
John Lewis - Presentation Designer (2004)
Education:
The Compton School
Matthew Lucas
Education:
Fuller Theological Seminary - Mdiv, Colorado School of Mines - Engineering