Matthew P Walters

US Patent:

20070087986, Apr 19, 2007

Filed:

Jul 31, 2006

Appl. No.:

11/496267

Inventors:

Brett Premack - San Francisco CA, US
Matthew Walters - Sunnyvale CA, US
Thomas Schall - Palo Alto CA, US

International Classification:

A61K 48/00
A61K 38/19

US Classification:

514044000, 424085100

Abstract:

The invention is directed to methods and compositions for enhancing immunity, including mucosal immunity. The compositions include an antigen or immunogen, a ligand for a Toll-like receptor and at least one chemoattractant.

US Patent:

20220211701, Jul 7, 2022

Filed:

Mar 27, 2020

Appl. No.:

17/599472

Inventors:

- Hayward CA, US
Devika Ashok - Belmont CA, US
Daniel M. DiRenzo - Palo Alto CA, US
Akshata R. Udyavar - Foster City CA, US
Matthew J. Walters - Pacifica CA, US
Stephen W. Young - Palomar Park CA, US

Assignee:

ARCUS BIOSCIENCES, INC. - Hayward CA

International Classification:

A61K 31/506
A61K 31/706
A61K 31/7076
A61K 45/06

Abstract:

The present disclosure provides methods of treating a cancer in a subject having an established adenosine fingerprint. An established adenosine fingerprint includes assessing the blood concentration of one or more adenosine machinery proteins, assessing the enzymatic activity of one or more adenosine machinery proteins, and/or assessing the tumor expression level of adenosine machinery proteins. The methods disclosed herein include administering to said subjects a therapeutic agent selected from the group consisting of an agent targeting the extracellular production of adenosine, and an agent antagonizing the activation by adenosine of one of its receptors.