Matthew H Weiss

US Patent:

20130338177, Dec 19, 2013

Filed:

Nov 18, 2011

Appl. No.:

13/988745

Inventors:

Ana Elena Minatti - Santa Monica CA, US
Oleg Epstein - Belmont MA, US
Ryan White - Somerville MA, US
Matthew Weiss - Boston MA, US
Wenge Zhong - Thousand Oaks CA, US
Jonathan D. Low - Tarzana CA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

C07D 491/107
C07D 491/20

US Classification:

514272, 544333, 514256, 546 15, 514278, 544231, 514275, 5483011, 514389

Abstract:

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula (I), wherein variables A, A, A, A, A, A, L, R, R, R, W and Y of Formula (I) are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to plaque formation and deposition, resulting from the activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas (II) and (III), sub-Formula embodiments of Formulas (I), (II) and (III), intermediates and processes and methods useful for the preparation of compounds of Formulae (I-III).