Matthew W Weiss

US Patent:

7872009, Jan 18, 2011

Filed:

Nov 14, 2006

Appl. No.:

11/600264

Inventors:

Brian K. Albrecht - Cambridge MA, US
Denise Lyn Andersen - Simi Valley CA, US
Michael Bartberger - Sherman Oaks CA, US
James Brown - Moorpark CA, US
Ryan Brown - Belmont MA, US
Stuart C. Chaffee - Philadelphia PA, US
Yuan Cheng - Newbury Park CA, US
Michael Croghan - Thousand Oaks CA, US
Russell Graceffa - Hampton NH, US
Scott Harried - Woodland Hills CA, US
Stephen Hitchcock - Westlake Village CA, US
Randall Hungate - Camarillo CA, US
Ted Judd - Simi Valley CA, US
Matthew Kaller - Ventura CA, US
Charles Kreiman - Watertown MA, US
Daniel La - Brookline MA, US
Patricia Lopez - West Hills CA, US
Craig Masse - Cambridge MA, US
Holger Monenschein - Camarillo CA, US
Thomas Nguyen - Thousand Oaks CA, US
Thomas Nixey - Newbury Park CA, US
Vinod F. Patel - Acton MA, US
Lewis Pennington - Camarillo CA, US
Matthew Weiss - Boston MA, US
Qiufen Xue - Newbury Park CA, US
Bryant Yang - Simi Valley CA, US
Wenge Zhong - Thousand Oaks CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

A61K 31/50

US Classification:

51425201, 544238, 544298, 544408, 546242, 549398

Abstract:

The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I.

US Patent:

8178557, May 15, 2012

Filed:

Jun 9, 2008

Appl. No.:

12/157303

Inventors:

Michele Potashman - Cambridge MA, US
Steven Bellon - Wellesley MA, US
Shon Booker - Thousand Oaks CA, US
Yuan Cheng - Newbury Park CA, US
Joseph L. Kim - Wayland MA, US
Andrew Tasker - Simi Valley CA, US
Ning Xi - Thousand Oaks CA, US
Shimin Xu - San Diego CA, US
Jean-Christophe Harmange - Andover MA, US
George Borg - Somerville MA, US
Matthew Weiss - Boston MA, US
Brian L. Hodous - Cambridge MA, US
Russell Graceffa - Hampton NH, US
William H. Buckner - Kittery ME, US
Craig E. Masse - Cambridge MA, US
Deborah Choquette - Medford MA, US
Matthew W. Martin - Arlington MA, US
Julie Germain - Quebec, CA
Lucian V. DiPietro - Gloucester MA, US
Stuart C. Chaffee - Boston MA, US
Joseph J. Nunes - Andover MA, US
John L. Buchanan - Newton MA, US
David C. McGowan - Brussels, BE
Douglas A. Whittington - Waltham MA, US
Gregory J. Habgood - Merrimac MA, US
Vinod F. Patel - Acton MA, US
Daniel La - Brookline MA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

A61K 31/04

US Classification:

514312

Abstract:

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

US Patent:

8426447, Apr 23, 2013

Filed:

Sep 11, 2009

Appl. No.:

12/558426

Inventors:

Ryan White - Somerville MA, US
Albert Amegadzie - Moorpark CA, US
Marian C. Bryan - West Hills CA, US
Jian Jeffrey Chen - Camarillo CA, US
Alan C. Cheng - Cambridge MA, US
Thomas Dineen - Somerville MA, US
Oleg Epstein - Belmont MA, US
Vijay Keshav Gore - Thousand Oaks CA, US
Zihao Hua - Tewksbury MA, US
Jason Brooks Human - Boston MA, US
Hongbing Huang - Lexington MA, US
Charles Kreiman - Watertown MA, US
Daniel La - Brookline MA, US
Qingyian Liu - Camarillo CA, US
Vu Van Ma - Simi Valley CA, US
Isaac Marx - Cambridge MA, US
Vinod F Patel - Acton MA, US
Wenyuan Qian - Camarillo CA, US
Matthew Weiss - Boston MA, US
Chester Chenguang Yuan - Newbury Park CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

A61K 31/44
C07D 311/82
C07D 401/00
C07D 413/00

US Classification:

514336, 5462681, 5462714, 549223

Abstract:

The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I.

US Patent:

20060241115, Oct 26, 2006

Filed:

Jan 24, 2005

Appl. No.:

11/042634

Inventors:

Michele Potashman - Cambridge MA, US
Steven Bellon - Wellesley MA, US
Shon Booker - Thousand Oaks CA, US
Yuan Cheng - Newbury Park CA, US
Joseph Kim - Wayland MA, US
Andrew Tasker - Simi Valley CA, US
Ning Xi - Thousand Oaks CA, US
Shimin Xu - Santa Barbara CA, US
Jean-Christophe Harmange - Andover MA, US
George Borg - Cambridge MA, US
Matthew Weiss - Boston MA, US
Brian Hodous - Cambridge MA, US
Russell Graceffa - Hampton NH, US
William Buckner - Arlington MA, US
Craig Masse - Cambridge MA, US
Deborah Choquette - Medford MA, US
Matthew Martin - Cambridge MA, US
Julie Germain - Medford MA, US
Lucian DiPietro - Gloucester MA, US
Stuart Chaffee - Cambridge MA, US
Joseph Nunes - Andover MA, US
John Buchanan - Brookline MA, US
Gregory Habgood - Merrimac MA, US
David McGowan - Woluwe St. Pierre, BE
Douglas Whittington - Waltham MA, US

International Classification:

A61K 31/517
A61K 31/502
A61K 31/498
A61K 31/4709
C07D 43/02

US Classification:

514248000, 514249000, 514266200, 514314000, 544237000, 544284000, 544333000, 546167000

Abstract:

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

US Patent:

20140031340, Jan 30, 2014

Filed:

Feb 6, 2012

Appl. No.:

13/982222

Inventors:

Thomas Dineen - Somerville MA, US
Matthew Weiss - Boston MA, US
Vinod F. Patel - Acton MA, US
Xiao Mai Zheng - Natick MA, US
Ryan White - Somerville MA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

C07D 498/20
C07D 498/10

US Classification:

51421115, 540543

Abstract:

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula (I); wherein variables A, A, A, A, A, A, R, R, X and Y of Formula (I) are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas (II) and sub-formula embodiments of Formula (I) and (II), intermediates and processes and methods useful for the preparation of compounds of Formulas (I)-(II).

US Patent:

20220356185, Nov 10, 2022

Filed:

Jul 3, 2019

Appl. No.:

17/258344

Inventors:

- Watertown MA, US
Nello MAINOLFI - Belmont MA, US
Matthew M. WEISS - Boston MA, US

International Classification:

C07D 487/04
C07D 401/14
C07D 519/00
C07D 417/14
C07D 401/04

Abstract:

The present invention provides compounds, compositions thereof, and methods of using the same.

US Patent:

20220358816, Nov 10, 2022

Filed:

Jul 21, 2022

Appl. No.:

17/870048

Inventors:

Matthew Weiss - New York NY, US

International Classification:

G07F 17/32

Abstract:

A method for playing a cooperative card wagering game for a plurality of players and a dealer using a customer cooperative wagering table and a deck of cards with each card having a numerical value, the cooperative wagering table having a dealer table edge, a community table edge, and a community line positioned therebetween, each player has an individual hand, and contributes a card to form a community hand by placing the card upon the community line, the players cooperate to maximize the value of the community hand, while also maximizing their respective individual hands, whereby the players cannot obtain a player win result if the community hand is less than the dealer's hand in value.

US Patent:

20220348556, Nov 3, 2022

Filed:

Jul 3, 2019

Appl. No.:

17/258339

Inventors:

- Watertown MA, US
Nan JI - Arlington MA, US
Arthur F. KLUGE - Concord MA, US
Matthew M. WEISS - Boston MA, US

International Classification:

C07D 401/14
A61P 35/00

Abstract:

The present invention provides compounds, compositions thereof, and methods of using the same for the targeted degradation of proteins, and the treatment of target protein-mediated disorders.