Maureen T Reilly

US Patent:

20220267273, Aug 25, 2022

Filed:

Dec 16, 2021

Appl. No.:

17/552929

Inventors:

- Princeton NJ, US
Benjamin M. COHEN - Princeton NJ, US
Kenneth Joseph FRAUNHOFFER - Princeton NJ, US
Sergei KOLOTUCHIN - Princeton NJ, US
Gregory Louis BEUTNER - Princeton NJ, US
Adam Joseph FREITAG - Princeton NJ, US
Michael Scott BULTMAN - Portage MI, US
Yu FAN - Highland Park NJ, US
Prantik MAITY - Bangalore, IN
Ian Scott YOUNG - Redwood City CA, US
Hilary Plake BECK - Emerald Hills CA, US
Maksim OSIPOV - Redwood City CA, US
Jay Patrick POWERS - Pacifica CA, US
Maureen Kay REILLY - Burlingame CA, US
Hunter Paul SHUNATONA - Oakland CA, US
James Ross WALKER - Verona WI, US

International Classification:

C07D 215/18
C07C 67/343
C07C 51/09
C07C 67/333

Abstract:

The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.

US Patent:

20210017171, Jan 21, 2021

Filed:

Jun 26, 2020

Appl. No.:

16/914209

Inventors:

- South San Francisco CA, US
Chengguo DONG - Staten Island NY, US
Timothy HOM - Sunnyvale CA, US
Lan JIANG - Foster City CA, US
Katerina LEFTHERIS - San Mateo CA, US
Hui LI - Santa Clara CA, US
Manuel MUNOZ - Vallejo CA, US
Maureen REILLY - Burlingame CA, US
Yajun ZHENG - Foster City CA, US

International Classification:

C07D 471/04
C07D 519/00

Abstract:

The invention relates to compounds of formula (A) and formula (I):or a salt thereof, wherein R, R, R, R, R, R, R, R, R, q and p are as described herein. Compounds of formula (A), formula (I), and pharmaceutical compositions thereof are αvβ6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

US Patent:

20200352942, Nov 12, 2020

Filed:

Apr 8, 2020

Appl. No.:

16/843824

Inventors:

- South San Francisco CA, US
Chengguo DONG - Staten Island NY, US
Timothy HOM - Sunnyvale CA, US
Lan JIANG - Foster City CA, US
Katerina LEFTHERIS - San Mateo CA, US
Hui LI - Santa Clara CA, US
Manuel MUNOZ - Vallejo CA, US
Maureen REILLY - Burlingame CA, US
Yajun ZHENG - Foster City CA, US
Martin DECARIS - Oakland CA, US
Scott TURNER - Oakland CA, US

International Classification:

A61K 31/5025
A61K 31/502
A61K 31/4375
A61K 9/00
A61P 11/00

Abstract:

The invention relates to dosage forms for daily administration of compounds of formula (A) and formula (I):or a salt thereof, wherein R, R, R, R, R, R, R, R, R, q and p are as described herein. Compounds of formula (A), formula (I), and pharmaceutical compositions thereof are αvβ6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

US Patent:

20200123109, Apr 23, 2020

Filed:

Jun 29, 2018

Appl. No.:

16/624448

Inventors:

- Princeton NJ, US
Benjamin M. COHEN - Princeton NJ, US
Kenneth Joseph FRAUNHOFFER - Princeton NJ, US
Sergei KOLOTUCHIN - Princeton NJ, US
Gregory Louis BEUTNER - Princeton NJ, US
Adam Joseph FREITAG - Princeton NJ, US
Michael Scott BULTMAN - Portage MI, US
Yu FAN - Highland Park NJ, US
Prantik MAITY - Bangalore, IN
Ian Scott YOUNG - Redwood City CA, US
Hilary Plake BECK - Emerald Hills CA, US
Maksim OSIPOV - Redwood City CA, US
Jay Patrick POWERS - Pacifica CA, US
Maureen Kay REILLY - Burlingame CA, US
Hunter Paul SHUNATONA - Oakland CA, US
James Ross WALKER - Verona WI, US

International Classification:

C07D 215/18

Abstract:

The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.

US Patent:

20190276449, Sep 12, 2019

Filed:

Mar 7, 2019

Appl. No.:

16/296194

Inventors:

- South San Francisco CA, US
Chengguo DONG - Staten Island NY, US
Timothy HOM - Sunnyvale CA, US
Lan JIANG - Foster City CA, US
Katerina LEFTHERIS - San Mateo CA, US
Hui LI - Santa Clara CA, US
Manuel MUNOZ - Vallejo CA, US
Maureen REILLY - Burlingame CA, US
Yajun ZHENG - Foster City CA, US

International Classification:

C07D 471/04
C07D 519/00

Abstract:

The invention relates to compounds of formula (A) and formula (I):or a salt thereof, wherein R, R, R, R, R, R, R, R, R, q and p are as described herein. Compounds of formula (A), formula (I), and pharmaceutical compositions thereof are αvβ6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).