Max E Safdy from 130 Acorn Ln, Point Harbor, NC 27964, age 83, Phone: (252)4912152

Ethyl 3-(3-Indolyl)-3-(5-Tetrazolyl) Propionate Compounds Used As Anti-Hypertensive Agents
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US Patent:

43339433, Jun 8, 1982
Filed:

Dec 15, 1980
Appl. No.:

6/216516
Inventors:

Elva Kurchacova - Elkhart IN
Max E. Safdy - Elkhart IN
Assignee:

Miles Laboratories, Inc. - Elkhart IN
International Classification:

A61K 3141
C07D25704
US Classification:

424269
Abstract:

Disclosed are novel ethyl 3-(3-indolyl)-3-(5-tetrazolyl) propionate compounds characterized by the formula: ##STR1## wherein X is H or methoxy and Y is H, Cl or methoxy. These compounds are useful as antihypertensive agents.

Process For The Preparation Of 3-Amino-2-(5-Fluoro And 5-Methoxy-1H-Indol-3-Yl)Propanoic Acid Derivatives
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US Patent:

42833361, Aug 11, 1981
Filed:

Oct 17, 1979
Appl. No.:

6/085915
Inventors:

Robert N. Schut - Edwardsburg MI
Max E. Safdy - Elkhart IN
Enrique Hong - Mexico City, MX
Assignee:

Miles Laboratories, Inc. - Elkhart IN
International Classification:

C07D20918
C07D20920
US Classification:

26032614R
Abstract:

The compounds having Formula I, ##STR1## wherein X is a fluorine or methoxy group, and R is a hydrogen or methyl group, such that R is hydrogen only when X is fluorine are novel. The compounds having Formula I and their acid addition salts are useful for the treatment of hypertension. Processes for the preparation of the compounds having Formula I and useful intermediates are described.

Methyl 3-Acetamido-2-(5-Methoxy-Indol-3-Yl) Propanoate And Hypotensive Use Thereof
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US Patent:

43930816, Jul 12, 1983
Filed:

Oct 28, 1981
Appl. No.:

6/315638
Inventors:

Robert N. Schut - Edwardsburg MI
Max E. Safdy - Elkhart IN
Enrique Hong - Cerro San Francisco, MX
Assignee:

Miles Laboratories, Inc. - Elkhart IN
International Classification:

A61K 31405
C07D20920
US Classification:

424274
Abstract:

Disclosed is the novel compound methyl 3-acetamido-2-(5-methoxyindol-3-yl) propanoate which is useful as an anti-hypertensive agent.

3-Amino Or Amido-2-(1H-Indol-3-Yl) Propanoic Acid Derivatives
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US Patent:

42834104, Aug 11, 1981
Filed:

Dec 26, 1979
Appl. No.:

6/107076
Inventors:

Robert N. Schut - Edwardsburg MI
Max E. Safdy - Elkhart IN
Enrique Hong - Cerro San Francisco, MX
Assignee:

Miles Laboratories, Inc. - Elkhart IN
International Classification:

A61K 31405
E07D20920
US Classification:

424274
Abstract:

Disclosed are compounds characterized by the structural formula: ##STR1## Various compounds circumscribed by the foregoing formula in which: R is H, CH. sub. 3 or CH. sub. 2 CH. sub. 3, R' is H, or ##STR2## X is H, F or OCH. sub. 3, Y is H or Cl, and Z is H or ##STR3## are therapeutically useful as anti-hypertensive agents.

Max E Safdy