Roy Curtiss iii - Paradise Valley AZ, US Melha Mellata - Tempe AZ, US Bereket Zekarias - Mesa AZ, US Zhaoxing Shi - Tempe AZ, US Christine Branger - Phoenix AZ, US Kenneth Roland - Mesa AZ, US
Assignee:
The Arizona Board of Regents for and on behalf of Arizona State University - Tempe AZ
International Classification:
A61K 39/112 C12N 1/21 A61P 37/04
US Classification:
4242581, 4352523
Abstract:
The present invention relates to a recombinant bacterium that is capable of eliciting an immune response against at least two enteric pathogens, without substantially inducing an immune response specific to the serotype of the bacterium. The invention also relates to methods of making such a bacterium and vaccines and methods of using such a bacterium.
Recombinant Bacterium Comprising A Toxin/Antitoxin System
The Arizona Board of Regents for and on behalf of Arizona State University - Tempe AZ
International Classification:
A61K 38/16
US Classification:
4242581, 4352523
Abstract:
The present invention encompasses recombinant bacteria suitable for live attenuated vaccines, and methods of use thereof. One aspect of the present invention encompasses a recombinant bacterium. The bacterium comprises a first promoter operably linked to a nucleic acid encoding a toxin and a second promoter operably linked to a nucleic acid encoding an antitoxin, wherein the second promoter is inactive in vivo, but active in vitro.