Min He - Congers NY, US John Hucul - New City NY, US Bradley Arnold Haltli - Monsey NY, US Melissa M. Wagenaar - Goshen NY, US Edmund Idris Graziani - Chestnut Ridge NY, US Mia Summers - Nyack NY, US Kerry Kulowski - Ringwood NJ, US Kevin Pong - Robbinsville NJ, US Xidong Feng - Fair Lawn NJ, US
Assignee:
Wyeth LLC - Madison NJ
International Classification:
C07D 498/18 A61K 31/435
US Classification:
514291, 540456
Abstract:
A polyketide synthase complex composed of polyketide synthase with 15 total modules, a non-ribosomal peptide synthetase with 1 module, and a cytochrome P450 hydroxylase is described. Also provided are novel species and methods of modified species. Further described are novel compounds, 36-ketomeridamycin, C9-deoxomeridamycin, and C9-deoxoprolylmeridamcyin and uses thereof.
Biosynthetic Gene Cluster For The Production Of A Complex Polyketide
Min He - Congers NY, US John Hucul - New City NY, US Bradley Haltli - Monsey NY, US Melissa Wagenaar - Nyack NY, US Edmund Graziani - Ridgewood NJ, US Mia Summers - Nyack NY, US Kerry Kulowski - Ringwood NJ, US Kevin Pong - Robbinsville NJ, US
A polyketide synthase complex composed of polyketide synthase with 15 total modules, a non-ribosomal peptide synthetase with 1 module, and a cytochrome P450 hydroxylase is described. Also provided are novel species and methods of modified species. Further described are novel compounds, 36-ketomeridamycin, C9-deoxomeridamycin, and C9-deoxoprolylmeridamcyin and uses thereof.
Pfizer since 2009
Senior Research Scientist II
Wyeth Research since Sep 2001
Senior Research Scientist II
Education:
Cornell University 1994 - 2000
Lake Forest College 1990 - 1994
Woodstock High School 1986 - 1990
Skills:
Chemistry Laboratory Characterization Lc Ms Drug Design Medicinal Chemistry High Throughput Screening Natural Products Biopharmaceuticals Drug Development Nmr Drug Discovery Chromatography Peptides Analytical Chemistry Mass Spectrometry Purification Organic Synthesis Cell Biology Hplc Organic Chemistry Pharmaceutical Industry Glp
Melissa Wagenaar 1998 graduate of Bishop Grandin High School in Calgary, AB is on Memory Lane. Get caught up with Melissa and other high school alumni from ...