Micha E Drukker

US Patent:

20130209415, Aug 15, 2013

Filed:

Jun 1, 2011

Appl. No.:

13/701425

Inventors:

Reza Ardehali - Redwood City CA, US
Irving L. Weissman - Stanford CA, US
Micha Drukker - Stanford CA, US
Roeland Nusse - Stanford CA, US

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

International Classification:

C12N 5/071

US Classification:

424 937, 435366

Abstract:

Composition and methods are provided for the prospective enrichment of human cardiovascular progenitor cells, which can be differentiated into cardiomyocytes, from in vitro cultures of stem cells. The stem cells are cultured in conditions permissive for differentiation into cardiovascular progenitor cells, and cardiovascular progenitor cells are sorted for expression of one or more of the markers ROR2, CD13, KDR and PDGFαR, where the progenitor cells positively express these markers. Highly enriched populations of cardiomyocyte lineage cells can be obtained.

US Patent:

20130028909, Jan 31, 2013

Filed:

Jan 28, 2011

Appl. No.:

13/575511

Inventors:

Chad Tang - East Palo Alto CA, US
Irving L. Weissman - Stanford CA, US
Micha Drukker - Stanford CA, US

Assignee:

THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY - Palo Alto CA

International Classification:

A61K 39/395
A61P 35/00
C07K 16/28
C12N 5/071

US Classification:

4241561, 435325, 4241521, 5303882, 435332

Abstract:

Compositions and methods are provided for depletion of pluripotent cells. In one embodiment of the invention, methods are provided for depletion of pluripotent cells from a mixed population of differentiated cells and stem cells, to provide a population of cells substantially free of pluripotent stem cells. Monoclonal antibodies useful in depletion and in identification of pluripotent stem cells are also provided.