Michael James Bacica from 4262 Valeta St, San Diego, CA 92107, age 50, Phone: (619)7589416

Michael Bacica Phones & Addresses

Buffered Formulations For Concentrating Antibodies And Methods Of Use Thereof
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US Patent:

20060182740, Aug 17, 2006
Filed:

Jun 23, 2003
Appl. No.:

10/518434
Inventors:

Michael Bacica - San Diego CA, US
Michael Labarre - San Diego CA, US
Assignee:

Biogen Idec, Inc. - San Diego CA
International Classification:

A61K 39/395
US Classification:

424133100
Abstract:

The present invention provides a method for producing a concentrated antibody preparation that includes the steps of: (a) obtaining an initial antibody preparation that is an aqueous solution of antibodies and histidine or acetate buffer at a concentration in the range of from about 2 mM to about 48 mM; and (b) subjecting the antibody preparation to membrane filtration so as to remove water and buffer but not antibodies from the antibody preparation, thereby producing an antibody preparation having a higher concentration of antibodies than the initial antibody preparation. The concentrated antibody preparations produced by the method have lower viscosity and are more stable than those of other formulations. The invention further includes concentrated antibody preparations produced by the method, pharmaceutical compositions made using such preparations, and therapeutic methods in which such pharmaceutical compositions are administered to treat diseases.