Michael Bauer

US Patent:

7291493, Nov 6, 2007

Filed:

Dec 20, 2004

Appl. No.:

11/018645

Inventors:

Michael Bauer - Newton MA, US
Michael Richard Bedford - Wiltshire, GB
Derrick Allen Pulliam - Raleigh NC, US

Assignee:

Syngenta Participations AG

International Classification:

C12N 9/24
C12N 1/00
C12Q 1/68
C12P 21/06
A23B 7/00
C07H 21/02
C07H 21/04

US Classification:

435200, 435 6, 435 691, 43525411, 4352542, 43525423, 4352543, 4352545, 4352546, 4352523, 4353201, 43525421, 4352544, 4352548, 4352549, 426 53, 426 54, 426 56

Abstract:

The present invention relates to codon-optimized xylanase coding sequences and the expression of xylanases in microbes and yeast. The invention further relates to using multiple copies of the xylanase expression construct for high levels of protein expression. The invention also relates to the use of xylanases as feed or food additives. The invention also relates to methods of expression of enzymes to increase thermotolerance by expressing them in organisms that glycosylate proteins compared to expression that the same enzyme without the glycosylation. Further, the invention relates to methods of preparing feed, enzyme feed additives, and methods of reducing the feed conversion ration or increasing weight gain of animals.

US Patent:

7662415, Feb 16, 2010

Filed:

Jun 22, 2007

Appl. No.:

11/821489

Inventors:

Michael Bauer - Newton MA, US
Michael Richard Bedford - Wiltshire, GB
Derrick Allen Pulliam - Durham NC, US

Assignee:

Syngenta Participations AG

International Classification:

A23K 3/00
C12N 9/24
C12N 9/00
C12P 21/06
A61K 38/43
A61K 38/54
C07H 21/04

US Classification:

426 53, 426 54, 426 56, 435200, 435183, 435 691, 424 941, 424 942, 536 232

Abstract:

The present invention relates to codon-optimized xylanase coding sequences and the expression of xylanases in microbes and yeast. The invention further relates to using multiple copies of the xylanase expression construct for high levels of protein expression. The invention also relates to the use of xylanases as feed or food additives. The invention also relates to methods of expression of enzymes to increase thermotolerance by expressing them in organisms that glycosylate proteins compared to expression that the same enzyme without the glycosylation. Further, the invention relates to methods of preparing feed, enzyme feed additives, and methods of reducing the feed conversion ration or increasing weight gain of animals.

US Patent:

8533038, Sep 10, 2013

Filed:

Feb 5, 2001

Appl. No.:

09/777614

Inventors:

Christopher P. Bergh - Lexington MA, US
Michael S. Bauer - Shrewsbury MA, US
Sidra Michon - Littleton MA, US
Zack Miloushev - Boxford MA, US
Kevin Furbish - Belmont MA, US
Charles Evett - Concord MA, US
Gregory Erman - Sudbury MA, US
John Mandel - Acton MA, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

G06Q 30/00

US Classification:

705 1435, 705 141, 705 1425

Abstract:

An offer delivery system provides a mechanism for coordinating presentation of offers to customers that may originate from multiple different sources and that may be delivered to the customers over different channels. The systems makes use of rules to prioritize, select, and time the delivery of offers to any particular customer, allocate limited resources in the channels to deliver offers to a set of customers, and provide mechanisms for users or their agents to limit the delivery of offers, for example, by their frequency or type.

US Patent:

8620740, Dec 31, 2013

Filed:

Oct 16, 2006

Appl. No.:

11/549797

Inventors:

Christopher P. Bergh - Lexington MA, US
Michael S. Bauer - Shrewsbury MA, US
Sidra Michon - Littleton MA, US
Zack Miloushev - Boxford MA, US
Kevin Furbish - Belmont MA, US
Charles Evett - Concord MA, US
Gregory Erman - Sudbury MA, US
John Mandel - Acton MA, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

G06Q 30/00

US Classification:

705 1435, 705 141, 705 1425

Abstract:

An offer delivery system provides a mechanism for coordinating presentation of offers to customers that may originate from multiple different sources and that may be delivered to the customers over different channels. The systems makes use of rules to prioritize, select, and time the delivery of offers to any particular customer, allocate limited resources in the channels to deliver offers to a set of customers, and provide mechanisms for users or their agents to limit the delivery of offers, for example, by their frequency or type.

US Patent:

20110053195, Mar 3, 2011

Filed:

Jun 12, 2007

Appl. No.:

12/303563

Inventors:

Michael William Bauer - Newton MA, US
Justin DeFontes - Cary NC, US

Assignee:

SYNGENTA PARTICIPATIONS AG - Basel

International Classification:

C12Q 1/34
C12N 9/24
C07H 21/04
C12N 15/63
C12N 1/15
C12N 1/21
C12N 1/19

US Classification:

435 18, 435200, 536 232, 4353201, 43525411, 4352523, 4352542, 43525423, 43525233, 43525231, 4352545, 4352543, 4352546, 4352549, 4352548

Abstract:

An inactive xylanase molecule for the recovery of xylanase activity in plant-derived material containing active xylanase enzyme(s) and xylanase inhibitors. The inactive xylanase molecule of binds to xylanase inhibitors in the plant-derived material, thereby allowing accurate measurement of xylanase enzyme activity of the enzyme contained in the plant-derived material. The invention further includes amino acid molecules depicted by SEQ ID NOS. 4 through 112, wherein the catalytically active sites of each of the amino acids have been modified resulting in inactive xylanase molecules. A method of production of the inactive xylanase molecules includes expression of the inactive xylanase molecule in microbial or eukaryal (e.g., yeast including ) host cell an expression cassette comprising a promoter operably linked to a nucleic acid molecule encoding the inactive xylanase molecule and using the expressed molecule in an assay to recover the xylanase enzyme activity in plant-derived material, for example, in plant-derived material such as animal feed.

US Patent:

20110208578, Aug 25, 2011

Filed:

May 4, 2011

Appl. No.:

13/100447

Inventors:

Christopher P. Bergh - Lexington MA, US
Michael S. Bauer - Shrewsbury MA, US
Sidra Michon - Littleton MA, US
Zack Miloushev - Boxford MA, US
Kevin Furbish - Belmont MA, US
Charles Evett - Concord MA, US
Gregory Erman - Sudbury MA, US
John Mandel - Acton MA, US

International Classification:

G06Q 30/00

US Classification:

705 1441

Abstract:

An offer delivery system provides a mechanism for coordinating presentation of offers to customers that may originate from multiple different sources and that may be delivered to the customers over different channels. The systems makes use of rules to prioritize, select, and time the delivery of offers to any particular customer, allocate limited resources in the channels to deliver offers to a set of customers, and provide mechanisms for users or their agents to limit the delivery of offers, for example, by their frequency or type.

US Patent:

57553785, May 26, 1998

Filed:

Jan 21, 1997

Appl. No.:

8/786721

Inventors:

Gerhard Allan Dage - Franklin MI
Leighton Ira Davis - Ann Arbor MI
Michael Bradley Bauer - Detroit MI

Assignee:

Ford Global Technologies, Inc. - Dearborn MI

International Classification:

G05D 2300

US Classification:

236 91C

Abstract:

Method and system for modifying the control of an automotive HVAC (heating, ventilation and air conditioning) to prevent the formation of cabin temperature stratification. The control algorithm responds to signals generated by various climate control sensors to calculate a value representing the likelihood of stratification. The stratification strategy achieves the following three functions: (1) calculation of the likelihood of stratification, (2) estimation of probable level of stratification, and (3) modification of strategy to dispel stratification. Fuzzy logic calculations are performed based on fuzzy rules and membership functions to provide these functions and to allow the control to be expressed in simple heuristic terms.

US Patent:

61739022, Jan 16, 2001

Filed:

Sep 16, 1999

Appl. No.:

9/397216

Inventors:

Michael Bradley Bauer - Detroit MI
Leighton Ira Davis - Ann Arbor MI

Assignee:

Ford Global Technologies, Inc. - Dearborn MI

International Classification:

F24F 700
G05D 2300

US Classification:

236 493

Abstract:

A method and system for automatically controlling a heating, ventilation and air-conditioning (HVAC) system of a vehicle in order to achieve thermal comfort of an occupant of the automotive vehicle receives a plurality of input signals representative of ambient temperature, sunload, and a set-point temperature. A desired amount of HVAC Work necessary to achieve thermal comfort is determined based on either a target temperature or a model of an occupant's thermal comfort. A controller controls the HVAC system based on the desired amount of HVAC Work.